European Psychiatry - Volume 41 - April 2017

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S60 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S53–S68
W023
Progressive frontal dysconnectivity
during working memory in eos
patients: A longitudinal functional
MRI study
S. Frangou , M. Kyriakopoulos ∗, D. Danai
1 New York, USA
2 King’s College London, Child and Adolescent Psychiatry, London,
United Kingdom
3 City University, Psychology, London, United Kingdom
∗ Corresponding author.
Working memory (WM) dysfunction is considered a cardinal
feature of schizophrenia. Typically developing adolescents show
significant gains in WM performance, which have been attributed
to increased “frontalisation” within the fronto-cingulate-parietal
network that underpins WM. We used functional magnetic res-
onance imaging and psycho-physiological interaction to measure
blood oxygenation level–dependent signal and functional connec-
tivity in response to the 2-back WM task from 25 youths with EOS
and 25 yoked healthy adolescents that were assessed twice with
a mean interval of 4 years between assessments. Patients showed
reduced prefrontal connectivity at baseline and the magnitude of
this effect increased over the follow-up period. Our results suggest
on-going functional connectivity abnormalities in EOS patients’
post-disease onset that are linked to prefrontal dysfunction and
contribute to worsening WM despite anti–psychotic treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
W024
Baseline, two-year, and five-year
follow-up of children and adolescents
with first-episode psychosis:
A Spanish cohort
J. Janssen ∗ chnack artínez antonja
Y. Aleman-Gomez ina-Camacho Fraguas oreno
C. Arango , M. Parellada
1 Hospital General Universitario Gregorio Mara˜nón- School of
Medicine- Universidad Complutense- IiSGM- CIBERSAM, Child and
Adolescent Psychiatry, Madrid, Spain
2 Brain Center Rudolf Magnus- University Medical Center Utrecht,
Psychiatry, Utrecht, The Netherlands
3 IISGM- Hospital Universitario Gregorio Maranon, Experimental
Medicine and Surgery, Madrid, Spain
∗ Corresponding author.
Background Early-onset first-episode psychosis (FEP) and high
functioning autism spectrum disorders (ASD) are complex
neuro–developmental disorders that share symptomatology but
it is not clear if they also share neurobiological abnormalities
(Chisholm et al., 2015). We examined thickness, surface area and
volume in a direct comparison of children and adolescents with FEP
(onset before 18 years), high-functioning ASD, and healthy subjects.
Methods Magnetic resonance imaging scans of 85 participants
(30 ASD, 29 FEP, 26 healthy controls, age range 10–18 years) were
obtained from the same MR scanner using the same acquisition
protocol. The FreeSurfer analysis suite was used to quantify vertex-
wise estimates of the metrics thickness, surface area, and volume.
Results ASD and FEP had spatially overlapping insular deficits for
each metric. The transdiagnostic overlap of deficits was greatest
for volume (55% of all insular vertices) and smallest for thickness
(18%). Insular thickness and surface area deficits did not overlap in
ASD and overlapped only in 8% of all insular vertices in FEP.
Conclusions Morphological insular deficits are common to FEP
and high functioning ASD when compared to healthy participants.
The pattern of deficits was similar in both disorders, i.e. a largely
non-overlap of insular thickness and surface area. The non-overlap
provides further evidence that these metrics represent two inde-
pendent outcomes of corticogenesis, both of which are affected in
FEP and ASD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
W025
Enigma-collaborative analyses of
neuroimaging eop data: What have
we achieved?
I. Agartz ∗, V. Lonning , R. Smelror , M. Lundberg , T. Edbom ,
T.P. Gurholt
1 University of Oslo, Clinical Medicine, Oslo, Norway
2 Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden
∗ Corresponding author.
Introduction The ENIGMA-EOP collaboration aims to identify
structural phenotypic markers that robustly discriminate ado-
lescents with early-onset psychosis (EOP) from healthy controls
through mega- or meta-analysis of magnetic resonance imaging
(MR) data. Through larger samples we will obtain sufficient power
to detect the brain structural correlates, overcome some of the clin-
ical heterogeneity and characterize the developmental trajectories.
Methods Multiple linear regressionwas used to investigate struc-
tural brain differences in two Scandinavian adolescent EOP cohorts
(altogether 50 patients; ages 12.1-18.3 years (mean 16.4 years),
60% female; 68 controls; ages 12.0-18.8 years (mean 16.2 years),
62% female) acquired on two different 3 T GE MRI scanners.
The statistical analysis included site as a covariate in addition
to age, sex and intracranial volume (ICV). The results are pre-
sented by p-values, Cohens’s-d effect size and with an indication
of directionality. MRI scans were processed following the ENIGMA
) structural image processing protocols
using FreeSurfer (Fischl 2012) version 5.3.0 to measure subcortical
brain volumes.
Results Preliminary results show significant or trend-
significant group effects on right amygdala ( P = 0.001, d = 0.33,
patients < controls), total grey matter volume (P = 0.037, d = 0.21,
patients < controls), ICV (P = 0.028, d = 0.22, patients < controls)
and third ventricle (P = 0.067, d = 0.19, patients > controls). Sub-
analyses in the two individual groups show overlapping findings
in right amygdala. Previously reported enlarged lateral and 4th
ventricles, and caudate, from a similar Scandinavian adolescent
EOP cohort (Juuhl-Langseth, 2012) were not replicated.
Conclusion There is a need for larger subject samples in EOP to
better capture disease mechanisms. Research groups interested
in participating can join ENIGMA-EOP through:
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.