European Psychiatry - Volume 41 - April 2017

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S66 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S53–S68
1 Institute of psychiatry- psychology and neuroscience- King’s college
London, psychosis studies, London, United Kingdom
2 Institute of psychiatry- psychology and neuroscience- King’s college
London, health service and population research, London, United
Kingdom
3 Institute of psychiatry- psychology and neuroscience- King’s college
London, psychological medicine, London, United Kingdom
4 Institute of psychiatry- psychology and neuroscience- King’s college
London, MRC social- genetic & developmental psychiatry centre,
London, United Kingdom
∗ Corresponding author.
Evidence indicates thatmigrant and ethnicminority groups have an
elevated risk of psychosis in a number of countries. Social disadvan-
tage is one of the hypotheses put forward to explain these findings.
The aim of this study is to investigate main effects, association and
synergism between social disadvantage and migration on odds of
psychotic experiences. We collected information on social disad-
vantage and migration from 332 patients and from 301 controls
recruited from the local population in South London. Two indica-
tors of social disadvantage in childhood and six indicators of social
disadvantage in adulthood were analyzed. We found evidence that
the odds of reporting psychotic experience were higher in those
who experienced social disadvantage in childhood (OR= 2.88, 95%
CI 2.03-4.06), social disadvantage in adulthood (OR= 9.06, 95% CI
5.21–15.74) and migration (OR = 1.46, 95% CI 1.05–2.02). When
both social disadvantage and migration were considered together,
the association with psychosis was slightly higher for social disad-
vantage in childhood andmigration (OR 3.46, 95% CI 2.12–5.62) and
social disadvantage in adulthood and migration (OR 9.10, 95% CI
4.63-17.86). Migrant cases were not more likely than non-migrant
cases to report social disadvantage (p = 0.71) and no evidence of
an additive interaction between migration and social disadvantage
was found (ICR 0.32 95% CI -4.04–4.69). Preliminary results support
the hypothesis that the association between social disadvantage
and psychosis is independent of migration status.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
w044
Trauma and migration in first episode
psychosis
S. Tosato ∗ onetto arricone Ruggeri omassi
C. Morgan Eugei
1 University of Verona, department of neurosciences- biomedicine
and movement sciences- section of psychiatry, Verona, Italy
2 University of Bologna, department of medical and surgical sciences,
Bologna, Italy
3 Institute of psychiatry, health services & population research,
London, United Kingdom
4 Eugei group, Verona, Italy
∗ Corresponding author.
Introduction Researches show that the period of migration, or the
migration process itself, may confer an increased risk for psychosis.
Some studies have addressed whether the high rates of psychosis
found in migrants could be due to higher genetic or environmental
risk factors. Facing severe or chronic stress such as trauma, social
isolation, low socio-economic status, late-life social adversity may
result in long term, sometimes permanent, alterations of the bio-
logical stress response system, leading to the onset of psychosis.
Objectives This study aims to examine, in a large sample of first
episode psychosis patients, whether negative social experiences
like stressful life events and difficulties, trauma and isolation have
significantly higher frequencies inmigrants with respect to natives.
Methods The present study is conductedwithin the framework of
the EUGEI (European Network of National Schizophrenia Networks
Studying Gene Environment Interactions) study, a Europe-wide
incidence and case–control study of psychosis conducted in 12
centers chosen to include areas with large first and subsequent
generation migrant populations.
Data about age, gender, migration history, trauma, life events, eth-
nicity, social class and family history of mental disorders have been
collected.
Results Preliminary data on the relationship between trauma and
migration in first episode psychosis will be presented.
Conclusions Since migration is an important stressful life event,
and difficulties in integration in host countries may remain chronic,
it is important to identify in each context the most vulnerable
minority groups in order to implement targeted prevention inter-
ventions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
W045
The social defeat hypothesis of
schizophrenia: an update
E. Van der Ven
Leiden, The Netherlands
Research provides strong evidence of an elevated risk for devel-
oping psychotic symptoms and psychotic disorder among various
ethnic and other minority groups. Furthermore, ethnicity may
modify the risk for autism-spectrum disorder, but the evidence
of this is still thin. Misdiagnosis, selective migration and other
methodological artefacts are implausible explanations for the find-
ings on psychotic disorder. Instead, we propose that ‘social defeat’,
defined as the chronic experience of being excluded from the
majority group, may increase the risk for psychotic disorder by
sensitizing the mesolimbic dopamine system. Future challenges
lie in connecting the underlying biological mechanisms to behav-
ioral expression in socially excluded groups, as well as in bridging
the gap with the clinical field and the wider society by stimulat-
ing the implementation of strategies that strengthen the position
of minority populations.
Disclosure of interest The author has not supplied his declaration
of competing interest.
W046
Migration history and the onset of
psychotic disorders
I. Tarricone ∗, O. Lastrina , S. Tosato , M. Di Forti ,
R.M. Murray , B. Domenico , C. Morgan
1 Alma Mater Studiorum universtà di Bologna, department of medical
and surgical sciences, Bologna, Italy
2 Università di Verona, dipartimento di neuroscienze- medicina e
movimento, Verona, Italy
3 Institute of psychiatry- psychology and neuroscience King’s college
London, dept of social- genetic and developmental psychiatry,
London, United Kingdom
4 Institute of psychiatry- psychology and neuroscience King’s college
London, dept of psychosis studies, London, United Kingdom
∗ Corresponding author.
Introduction Research has established that there are high rates
of first episode psychosis (FEP) in immigrant populations. These
findings could indicate that socio-environmental risk factors, such
as individual social class, social capital, early trauma, life events,
neighborhood deprivation could be relevant in explaining the dif-
ferences in incidence rates observed betweenmigrants and natives,
following the socio-developmental model of Morgan et al. (2010).
Some preliminary results also indicate that migration history itself
versus ethnicity could implicate higher risk of the onset of psychotic
disorders.