European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S710–S771 S743
activities in open field test, brain cytokines synthesis and suppres-
sion of immune response were registered inmice with passive type
of behavior. Daily consumption of ethanol solution in mice with
chronic alcohol dependence decreased sharply starting from2 days
of anticonvulsant administration and led to the cessation of ethanol
consumption by the 5 day. After anticonvulsant administration for
10 days behavioral parameters inmicewere comparablewith those
in the control group of healthy animals. It also restored brain
cytokines synthesis and significant stimulated humoral immune
response, estimated by the relative number of antibody-forming
spleen cells.
Conclusion Behavior and immune changes following chronic
ethanol exposure depended on the behavior status of ani-
mals; administration of the original anticonvulsant meta-chloro-
benzhydryl-urea may correct both immune and behavior disorders
in mice with chronic alcohol dependence, so it has promise in the
treatment of alcoholism.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1042
Lymphocytes with Fas-receptors of
readiness to apoptosis in
non-psychotic mental disorders
V. Nikitina ∗, T.P. Vetlugina , O.A. Lobacheva , V.A. Rudnitsky ,
M.M. Axenov
1 Mental Health Research Institute, Tomsk National Research Medical
Center, Russian Academy of Sciences, Department of
Psychoneuroimmunology and Neurobiology, Tomsk, Russia
2 Mental Health Research Institute, Tomsk National Research Medical
Center, Russian Academy of Sciences, Borderline States Department,
Tomsk, Russia
∗ Corresponding author.
Introduction Apoptosis is a complex physiological process of the
organismwhich supports cellular homeostasis, provides important
aspects of development and functioning of the immune system.
In various pathological conditions the process of apoptosis can be
impaired that leads to decrease or increase in pro-apoptotic activ-
ity.
Materials and methods We conducted investigation of relative
and absolute number of CD3+CD95+–lymphocytes in groups of
patients with adjustment disorders (n = 90), PTSD (n = 100), organic
emotionally labile (asthenic) disorder (n = 232), organic personal-
ity disorder (n = 93). Clinical verification was conducted according
to ICD–10. Control group included 190 practically healthy persons.
Fas protein (CD95) expression on CD3 lymphocytes surfaces was
detected using flow cytometry. Cytometric measurements were
conducted on flow cytofluorimeter FacsCalibur (Becton Dickinson,
US).
Results In the control group relative number of CD95+–
lymphocytes was 11.6%, absolute–0.21 ×109/L. In all exam-
ined patients as compared with control the reliable increase
both in relative and absolute number of lymphocytes of
CD3+CD95+–phenotype was identified. So, in persons with
adjustment disorder content of this indicator made 17.0%
and 0.28 × 109/L (Р = 0.0015), in PTSD–18.0% and 0.33 × 109/L
(Р = 0.0007) and in patients with organic asthenic disorder–19.0%
and 0.32 × 109/L (Р = 0.0048), respectively. The highest content
in blood of CD3+–lymphocytes, expressing on the surface of
membrane the basic marker of apoptosis CD95 is observed in
patients with organic personality disorder: 26.0% and 0.44 × 109/L
(Р = 0.0003).
Conclusion In case of intensification of psychopathological symp-
toms especially in persons with non-psychotic organic mental
disorders a receptor-mediated signaling pathway of apoptosis is
activated – process of programmed cell death.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1043
Inflammatory markers in mild
cognitive impairment and anxiety
disorders in middle-aged subjects
with metabolic syndrome
V. Piotrovskaya ∗, N. Neznanov
First State Pavlov Medical University, Psychiatry, St. Petersburg,
Russia
∗ Corresponding author.
Anxiety disorders are increasingly being associated with metabolic
and cardiovascular burden, in contrast with depression; the role
of inflammation in anxiety has sparsely been discussed. A num-
ber of reports of elevated inflammatory markers in mild cognitive
impairment (MCI) suggest that inflammation may be a potential
early marker of the pathological cascade associated with dementia.
The aimof this studywas to evaluate a possible association between
peripheral blood concentrations of inflammatory factors in patients
with MCI and mental processes such as, cognitive impairment and
anxiety in obesity.
Methods and results The data collected from 271 patients with
MetS according IDF criteria, (aged 30–60 years) have been analyzed.
Lifetime diagnoses of depression (D), anxiety (A) was self-reported.
Current D and A were confirmed by psychodiagnostic interview
according to the criteria of ICD-10. All patients passed through:
MMSE test, Wechsler memory scale, symbol coding and category
Fluency test, scales HADS, HAM-A. Inflammatory markers included
CRP, IL-6, IL-1 and TNF- . Subjects were divided into group A–with
D and/or A (139) and group B–without affective disorders (132).
Using Mann–Whitney test significant connection between pres-
ence of MCI and high levels of inflammation is associated with
simultaneous presence affective disorders. High correlations in
subjects with A/D were between IL-6, IL-1 and MCI. In-group B,
there was no significant correlations between inflammatory mark-
ers and MCI.
Conclusion There is link between affective disorders and levels
of inflammatory markers. Increased levels of IL-6 and IL-1 provoke
co-morbidity of MCI and depression or anxiety.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1044
Autoimmune limbic encephalitis:
When psychiatric symptoms are not
what they seem
A. Samico ∗, Â. Venâncio
Vila Nova de Gaia Hospitalar Center, Psychiatry and Mental Health
Service, Vila Nova de Gaia, Portugal
∗ Corresponding author.
Introduction The autoimmune (AI) limbic encephalitis (LE) can
manifests as changes in neuropsychiatric functions and can even
occur with isolated psychiatric symptoms. Many times it is a man-
ifestation of paraneoplastic syndromes and it is lately diagnosed.
Objectives Our objective is to increase awareness to this pathol-
ogy, since initial contact with these patients is often performed by a
psychiatrist and its early detection and treatment greatly improve
the prognosis of the patients.
Aims The aim of this presentation is to address the AI LE as a
differential diagnosis in patients with psychiatric symptoms.
Methods Presentation of a clinical case of AI LE and syndrome
revision.