European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S772–S846 S795
batteries and useful tools for research in several scientific domains,
including psychiatry, psychology, genetics and neurosciences.
Aims To validate and disseminate the Portuguese PennCNP bat-
tery for clinical and non-clinical studies.
Objectives To translate and provide preliminary psychometric
data of the Portuguese PennCNP tests in 9 neurocognitive domains.
Method The PennCNB (Gur et al., 2010) was translated and
administered to a sample of 120 Portuguese participants from the
general population.
Results Findings on the internal consistency and performance
(speed and accuracy) are presented for the 19 tasks included in the
PennCNB, in addition to results of correlation analysis within tests
on the same domain for criterion validity, and gender sensitivity
analysis.
Conclusion Computerized assessment provides efficient and reli-
able results, based on performance of abstract.
Objective and simple tasks that cover a vast range of cognitive func-
tions The administration requires minimal training and provides
a quick and automated scoring procedure, with great utility in sev-
eral research and clinical fields. The availability of a test battery
suitable for a large number of Portuguese native-speakers world-
wide is of added value, since the translation of measures to several
languages allows creating more extensive normative samples and
direct results comparability in future research, including transna-
tional or cross-cultural studies and clinical trials.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1199
“Neurodevelopment in a dish”
Elucidates the mechanisms of autism
spectrum disorder
M. Ilieva ∗ Kamand olev . Forsberg
Å.F. Svenningsen heldrick-Michel
1 Odense University Hospital, Psychiatry, Odense, Denmark
2 Odense University Hospital, Neurobiology research, Odense,
Denmark
∗ Corresponding author.
Introduction Autism spectrum disorders (ASD) is a group of
neurodevelopmental disorders characterized by deficits in social
cognition, communication, and behavioral flexibility. Most of the
cases appear to be caused by the combination of autism risk genes
and environmental factors affecting early embryonal brain devel-
opment. The current animal and 2D cellular models are not able to
recapitulate the complex integrity of the developing brain. There-
fore a model of the brain that can cast a light on the pathological
processes during brain development is of a high need.
Aim and objectives The aim of our research is to develop a
three-dimensional brain organotypic system (brain organoids) for
culturing patient’s derived induced pluripotent stem cells (iPSC).
Methodology We propose a multidisciplinary approach, involv-
ing the generation of patient specific iPSC from somatic cells
(fibroblasts) and 3D culturing techniques to build a complex
“humanized” in vitro platform for ASD research. Further we will
investigate differences in gene expression of potential disease
related markers and cellular phenotype between autistic patients
and controls.
Results Brain organoids have the ability to recreate the right com-
plexity of the brain. On the cellular and gene expression level,
organoids demonstrate a high similarity to the neurodevelopment
in vivo and can therefore recapitulate early stages of the neurogen-
esis.
Conclusion To date organoids are the most relevant cellular
in vitro platform for the understanding the mechanisms behind
ADS pathology. Organoids are a good modeling system for elu-
cidating the role of epigenetic and environmental factors for
development of ASD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1200
Pictorial representation of illness and
self-measure as an instrument for
diagnostic of illness representation in
youth with ultra-high risk for
psychosis
M. Kovyazina ∗, E. Rasskazova , N. Varako , S. Enikolopov
1 Lomonosov Moscow State University, Department of Psychology,
Moscow, Russia
2 Lomonosov Moscow State University and Mental Health Research
Center laboratory of Medical Psychology, Department of Psychology,
Moscow, Russia
∗ Corresponding author.
Introduction Pictorial representation of illness and self-measure
(PRISM) was developed as screening tool assessing implicit reac-
tion to somatic illnesses. Conclusion is based on comparisons of
the positions of illness-related (“Illness” and major symptoms) and
unrelated (“Me”, “Family”, “Work/study”) objects on the list.
Objectives Due to its easiness and implicitness PRISM could
be promising addition to illness representation questionnaires in
mental illnesses.
Aim was to reveal validity of the PRISM in youth with ultra-high
risk for psychosis.
Methods Eighty-one male patients 16–25 years old meeting
criteria of ultra-high risk for psychosis; preliminary diagnoses of
mood disorders 34, personality disorders 26, schizotypal disorder
21 patients) filled PRISM, beck cognitive insight scale, symptom
checklist 90-r, illness perception questionnaire, quality of life and
enjoyment questionnaire and happiness scale.
Results According to hierarchical regression, conditional “Self-
Illness” distance (after control for mean distances on the list) was
related to less psychopathological complaints, lower subjective
illness severity and emotional representations, higher treatment
control and better quality of life. “Self-symptoms” distance was
related to better cognitive insight, lower emotional representa-
tions and consequences and moderated the relationship between
“Self-Illness” distance and appraisals of illness length and dynamic.
Conclusions Conditional “Self-Illness” distance in PRISM could
reflect cognitive appraisal of illness based on symptoms and related
to life satisfaction while “Self-Symptoms” distance reflects merely
emotional reaction based on cognitive insight.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1201
Towards a new structure of the
interpersonal reactivity index.
reliability and validation of the
Portuguese version: A comparative
analysis
L. Manarte
Faculty of Medicine, Psychiatry, Lisbon, Portugal
Objective Empathy has received a lot of attention with the cre-
ation of an Interpersonal Reactivity Index (IRI). IRI is assessed using
a 28-item questionnaire with four 7-item scales:
– perspective-taking (PT) scale;
– fantasy (FS) scale;