European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S772–S846 S811
EV1241
Victimization and perpetration of
crime in patients with schizophrenia
and related disorders involuntarily
admitted
F. Fortugno
Queen Mary University of London, Unit for Social and Community
Psychiatry, London, United Kingdom
Introduction Incidence of crime victimization and perpetration is
higher in severely mentally ill people than in general population.
In the literature, fewer papers investigate the risk of being a victim
than the risk of perpetrating violence in psychiatric patients.
Objectives To study incidence of self-reported crime victimisa-
tion or perpetration in 2 multicentric database of patients suffering
from schizophrenia or related psychoses who are admitted invol-
untarily to hospital.
Methods Included involuntarily admitted patients with ICD-10
diagnosis of F20-F29, age 18–65, giving informed consent. Univari-
able and multivariable logistic regression to estimate odds ratios.
Structured interview and BPRS by trained operators.
Results Three hundred and eighty-three and 543 cases for each
database. Victims: 37.8% and 28.0%. Accused: 25.6% and 11.6%. Vic-
tims had higher BPRS subscale of Mania, were unemployed and
had fewer social contacts. Accused had higher mania in one of the
2 sample. Sociodemographic predictors included unemployment
and homelessness, younger age and male gender.
Discussion Sociodemographic factors are important predictors of
being accused of a crime. Higher symptoms of mania are associated
with higher odds of being victim of violence in 2 multicentric sam-
ples, after correction for other variables. Rates of both victimisation
and perpetration rates are higher than in samples of people from
general population or from outpatients settings. Accused and vic-
tims have a strong association with consideration on the context of
life.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EV1242
CB1-5-HT2A heteromers in
schizophrenia patients: Human
studies in pro-neurons of the
olfactory epithelium
L. Galindo ∗, P. Robledo , D. Guinart , E.J. Pérez ,
A. Cuenca-Royo , E. Menoyo , C. Fernandez , J. García ,
E. Moreno , V. Casadó , R. de la Torre , V. Perez-Solá ,
P. Salgado , S. Oller , M. Campillo , O. Orejas
1 Neurosciences Research Programme, IMIM-Hospital del Mar
Medical Research Institute.Neuropsychiatry and Addictions Institute
of Parc de Salut Mar, Departament de Psiquiatria i Medicina Legal.
Universitat Autònoma de Barcelona, Barcelona, Spain
2 Neurosciences Research Programme, IMIM-Hospital del Mar
Medical Research Institute, Integrative Pharmacology and Systems,
Barcelona, Spain
3 The Zucker Hillside Hospital, Northwell Health, Departament de
Psiquiatria i Medicina Legal. Universitat Autònoma de Barcelona,
New York, USA
4 Faculty of Biology, University of Barcelona, Department of
Biochemistry and Molecular Biomedicine, Barcelona, Spain
∗ Corresponding author.
Introduction Despite multiple clinical and preclinical studies
investigating schizophrenia, the neurobiological basis of this dis-
ease is still unknown. The dysregulation of the serotonergic system,
in particular the 5-HT2A receptor and the endocannabinoid system
have been postulated as possible causes of schizophrenia.
Objectives The aim of this study is to evaluate the expression
of CB1-5-HT2A receptor heteromers in primary cultures of pro-
neurons from the olfactory epithelium in schizophrenia patients
and control subjects.
Methods We recruited a group of 10 healthy volunteers and 10
patients diagnosed with schizophrenia, who were treated with
atypical antipsychotics, were clinically stable and had an illness
duration range from 1 up to 15 years. The patients were diag-
nosed with schizophrenia from the medical record and confirmed
by the structured clinical interview for DSM disorders. The expres-
sion of CB1-5-HT2A receptor heteromers in primary cultures of
pro-neurons from the olfactory epithelium was quantified using
proximity ligation assays and confocal microscopy.
Results Olfactory epithelium pro-neurons were viable and
expressed the neuronal marker, III- tubulin. We also estab-
lished the presence and the functionality of CB1-5-HT2A receptor
heteromers in these cells using the proximity ligation and
cAMP activity assays, respectively. Heteromer expression was sig-
nificantly increased in schizophrenia patients with respect to
controls.
Conclusions This highly innovative methodology will allow the
noninvasive, low-cost study of new biomarkers for schizophrenia
in a model closely related to the central nervous system.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.Acknowledgments
This work was supported by grants from DIUE-Generalitat-de
Catalunya (2014SGR 680), Instituto de Salud Carlos III (PI14/00210)
and (PI10/01708) FIS-FEDER-Funds. LG is supported by the
Instituto-de Salud Carlos III through a “Río Hortega” (CM14/00111).
EV1243
Ziprasidone and pulmonary
embolism, report of a case
S. Garcia Marin ∗ Martínez Pedrosa e Haro García
M.D. Ortega García
1 Centro Salud Mental Lorca, Adultos, Lorca, Spain
2 Hospital Vinalopó, Adultos, Elche, Spain
3 Centro de Salud Mental Cartagena, Adultos, Cartagena, Spain
∗ Corresponding author.
Introduction Several scientific studies support the relation
between pulmonary embolism and antipsychotic treatment (acute
or chronic). We present a case of possible association of venous
thromboembolism (VTE) and ziprasidone.
Personal antecedents Man, 55-year-old, with mild hypertension.
He has neither toxics habits nor allergies. He does exercise every
day. He started with behavioral and perception disorders during
9 months before being diagnosed of paranoid schizophrenia in
2002. He began with risperidone 3mg per day and amisulpride
25mg per day as hypnotic. It allowed a good development and
he keeps stable since then. The treatment produced sedation and
weight increase, so it was changed to ziprasidone 60mg per day
and later 40mg per day. A few months ago, he was hospitalized
with breathelessness that started suddenly two days before. After
all diagnostic tests, he was diagnosed with pulmonary embolism
and right leg VTE. His medical development was very positive and
he must begin with acenocumarol (doses–depend) and support
stockings.
Conclusion As we know, since last 10 years, antipsychotic expo-
sure significantly increases the risk of pulmonary embolism. Due
to the lack of risk related factor in this case, it would point that
reason. The increase related is about 50% of developing VTE and
this increased risk similarly applies to first and second generation
antipsychotics drugs. Despite that, there are more cases in olanza-
pine, clozapine and haloperidol treatments due to antiaggregatory
action and antithrombotic effects. We present this case probably
closely related with ziprasidone.