European Psychiatry - Volume 41 - April 2017

835 / 916

25th European Congress of Psychiatry / European Psychiatry 41S (2017) S772–S846 S831
Table 1
Admission No admission Marginal
row totals
P value
First generation
antipsychotic
7 (6) [0.17] 17 (18) [0.06] 24 0.414216
Second generation
antipsychotic
2 (3) [0.33] 10 (9) [0.11] 12
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1300
Nicotine dependence is associated
with depression and childhood
trauma in smokers with
schizophrenia. Results from the
Face-SZ dataset
R. Rey ∗, T. D’amato , P.M. Llorca , G. Fond
1 CH Le Vinatier, Pôle EST, Centre Expert Schizophrénie, Bron cedex,
France
2 CHU de Clermont Ferrand, CMP B, Clermont Ferrand, France
3 Hôpitaux Universitaires H Mondor, Pôle de Psychiatrie, Créteil,
France
∗ Corresponding author.
Introduction In a perspective of personalized care for smok-
ing cessation, a better clinical characterization of smokers with
schizophrenia (SZ) is needed. The objective of this study was to
determine the clinical characteristics of SZ smokers with severe
nicotine (NIC) dependence.
Methods Two hundred and forty stabilized community-dwelling
SZ smokers (mean age = 31.9 years, 80.4% male gender) were con-
secutively included in the network of the FondaMental Expert
Centers for schizophrenia and assessed with validated scales.
Severe NIC dependence was defined by a Fagerstrom question-
naire score ≥7. Major depression was defined by a Calgary score
≥6. Childhood trauma was self-reported by the Childhood Trauma
Questionnaire score (CTQ). Ongoing psychotropic treatment was
recorded.
Results Severe NIC dependence was identified in 83 subjects
(34.6%), major depression in 60 (26.3%). 44 (22.3%) subjects
were treated by antidepressants. In a multivariate model, severe
NIC dependence remained associated with major depression
(OR = 3.155, P= 0.006), male gender (OR = 4.479, P= 0.009) andmore
slightly with childhood trauma (OR = 1.032, P = 0.044), indepen-
dently of socio-demographic characteristics, psychotic symptoms
severity, psychotropic treatments and alcohol disorder.
Conclusion NIC dependence was independently and strongly
associated with respectively major depression and male gender in
schizophrenia, and only slightly with history of childhood trauma.
Based on these results, the care of both nicotine dependence and
depression should be evaluated for an effective smoking cessation
intervention in schizophrenia. Bupropion, an antidepressant that
has been found as the potential most effective strategy for tobacco
cessation in schizophrenia to date, may be particularly relevant in
male SZ smokers with comorbid major depression.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1301
Schizoaffective disorder and
schizophrenia: Clinical differences
F. Romosan∗, L.M. Ienciu , A.M. Romosan , R.S. Romosan
“Victor Babes” University of Medicine and Pharmacy, Neuroscience,
Timisoara, Romania
∗ Corresponding author.
Introduction Schizoaffective disorder (SAD) and schizophrenia
(SZ) are important causes of disability and morbidity. Finding clin-
ical features that can help in their early differentiation may lead to
a better understanding of these two nosologic entities.
Objectives The purpose of this study was to find clinical differ-
ences between SAD and SZ.
Methods We selected for this study 83 inpatients from the
Timisoara Psychiatric Clinic, diagnosed with either SAD (n = 35) or
SZ (n = 48), according to ICD-10 criteria. The research was con-
ducted between 2014 and 2016. Socio-demographic (age, sex,
education, marital status) and clinical data were analysed. The Brief
Psychiatric Rating Scale (BPRS) was used to assess symptom sever-
ity.
Results Delusions of grandiosity were found significantly more
frequent in SAD patients (P = 0.001). By contrast, bizzare delusions
(P = 0.025), derealization phenomena (P = 0.03) and negative symp-
toms (P= 0.003) appeared more frequent in schizophrenic patients.
We found no significant differences between the two samples
regarding onset age, number of episodes, duration of episode, dura-
tion of remission and suicidal thoughts/attempts. Although the SZ
sample had higher BPRS total scores than SAD patients, the differ-
ences were not statistically significant.
Conclusions Even though SAD and SZ are very similar in respect
to their clinical presentation, this study also revealed certain dif-
ferences that may enhance specific knowledge regarding these two
disorders.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1302
Urban Spaces and psychic disease:
A case series from Florence
E. Rondini∗, M. Bertelli
Fondazione San Sebastiano, CREA Centro di Ricerca e Ambulatori,
Florence, Italy
∗ Corresponding author.
Peoplewith schizophrenia or other psychoses present alterations of
multi-sensory processing and impairments in cognitive functions.
They seem to be more sensitive to external stimuli than the gen-
eral population, which can negatively impact on their emotional
state. The purpose of the studywas to assess howelements of urban
milieu combine with spatial experiences of people with these dis-
orders, affecting their spatial perceptions and social interactions.
The group of participants consisted of 10 patients aged between
20 and 40 years, with schizophrenia or other psychoses. We used
qualitative methods to assess behaviours in different urban routes,
including a period of participant observation and a series of semi-
structured interviews. Pathways within the city were recorded
using a Global Position System (GPS), in order to link perceptual
and behavioural data to specific urban spaces. The data analysis
has revealed positive interactions between most of participants
and the city. Different places have been differently perceived in
terms of stress and comfort. The wide squares and the art-rich
sites of the city center, as well as public parks and gardens, have
been connected with positive feelings and senses of pleasure. Con-
versely, the presence of a high number of people and themovement
experiences through public transport services have emerged to
be associated with negative emotions. A deeper understanding of