European Psychiatry - Volume 41 - April 2017

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S832 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S772–S846
mechanisms and processes that interest the link between urban
space and psychological disease can contribute to show new direc-
tions for the improvement of urban life quality and to progress both
in psychiatry and in urban planning.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1303
The awareness of social inference task
(TASIT) updated: Signal detection
theory (SDT) in emotion recognition
and its link to psychotic symptoms
R. Rossi ∗, V. Santarelli , M. Carmela , D. Gianfelice ,
R. Cicciarelli , F. Pacitti , A. Rossi
1 University of L’Aquila, Applied Clinical Sciences and Biotechnologies
DISCAB, L’aquila, Italy
2 SPDC Ospedale San Salvatore, DSM, L’aquila, Italy
∗ Corresponding author.
Introduction Social cognition (SC) is an impaired domain in
schizophrenia. However, little is known on the Signal Detection
properties of SC deficits.
We analyzed the relationship between emotion perception and
psychotic symptoms in a sample of schizophrenic patients. For this
scope, we extended the scoring system of the awareness of social
inference task-emotion recognition (TASIT-ER) according to signal
detection theory (SDT).
Methods Sample:
– one hundred and nineteen inpatients from L’Aquila Inpatient unit
diagnosed with schizophrenia.
Dependent variable:
– Positive and Negative Syndrome Scale (PANSS)’s Positive, Neg-
ative, Disorganized, Excited and Depressed dimensions, and total
score.
Independent variable:
– a modified version of TASIT-ER. The original scoring system,
including only “HITs”, was extended with “False Alarm” (FA),
defined as a detection of an emotion when not present.
Statistical analysis:
– multivariable linear regression models for each sub-group of
emotions to assess the effect of FAs on psychotic symptoms com-
pared to HITs.
Results FAs on positive emotions were associated with dis-
organized (b = 31.95), excited dimensions (b = 41.84) and PANSS
Total ( b = 152.46); FAs on negative emotions were associated with
Excited dimension (b = −57.97) and PANSS Total (b= −243.70). HITs
on Negative emotions were associated with Negative (b = −13.37),
Disorganized (b = −8.64) Excited (b = −8.74) dimensions and with
PANSS total (b = −45.30).
Discussion FA rates were more strongly associated with total
PANSS score than HIT rate, suggesting a prominent role of false
recognition in defining psychotic symptoms, especially disorga-
nized and excited ones, consistently with computational models
of psychosis that rationalize false recognition as failures of active
inference systems in updating their predictive model of sensory
information.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1304
Can the ‘mediation’ approach help to
understand the role of lack of insight
in the relationship between symptoms
and functioning in schizophrenia?
R. Rossi ∗, V. Santarelli , C. Marucci , G. Pizziconi , F. Pacitti
Univeristy of L’aquila, DISCAB, L’aquila, Italy
∗ Corresponding author.
Introduction The relationship between Lack of insight (LoI) and
other symptoms in schizophrenia is complex. LoI could be associ-
ated with severity of symptoms at one side and global functioning
at the other. For this nature LoI is a candidate ‘mediator’ for the
relationship between psychotic symptoms and global functioning.
Objectives The aim of this study is to explore the possible role of
LoI as a mediator between psychotic symptoms and global func-
tioning in a sample of people with schizophrenia.
Methods Seventy-three patients with a diagnosis of schizophre-
nia were included. The five-factor model of the PANSS by Wall
work was used to assess psychopathology and G12 item as an esti-
mate of LoI. Global assessment of functioning (GAF) was used to
measure global disability. Pearson’s r correlations and linear regres-
sions for Sobel test for mediation were performed. PANSS factors
were modeled as predictors of global functioning and LoI as the
mediator.
Results Correlations revealed the prerequisite relationships
between LoI, positive, negative and disorganized PANSS factors
and global functioning. Mediation analyses show that LoI partially
mediates the relationship between positive and disorganized fac-
tor scores and global functioning. No mediation for negative factor
score was observed.
Conclusions Lack of insight mediates the relationships between
positive and disorganized factors and global functioning. The par-
tial mediation we report suggests that LoI on the one hand is an
independent contributor to global function, but further shows an
indirect effect of PANSS positive and disorganized factors to GAF
total score.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1305
Characteristics of pre-morbid
functioning in male adolescents who
later suffered from psychotic
disorders: Case-controlled study
K. Rubinstein ∗, O. Bhuknik-Atzil , R. Tuval-Maschiach ,
E. Fruchter , M. Weiser
1 Tel Aviv University, The Sackler Faculty of Medicine, Tel Aviv, Israel
2 Ben-Gurion University, Education, Beer Sheva, Israel
3 Bar Ilan University, Psychology, Ramat Gan, Israel
4 IDF, Mental Health Division, Ramat Gan, Tel Hashomer, Israel
5 Sheba Medical Center, Division of Psychiatry, Ramat Gan, Israel
∗ Corresponding author.
Background Previous research has shown that people with psy-
chotic disorders have impaired functioning prior to the onset of
the illness. The main goal of the proposed study was to deepen
understanding of the characteristics of pre-morbid impairment in
persons later diagnosed with psychotic disorders.
Methods We examined unique pre-morbid data from IDF
archives, including narrative summaries of pre-induction inter-
views of 17-year old adolescents (168 male adolescents who were
later hospitalized for psychotic disorders, and 168 matched control
subjects). The data were analyzed using mixed-method analysis,
combining qualitative and quantitative research methods.
Results Between group comparisons revealed more adaptation
difficulties, family problems and dealing with medical conditions
in the group of future psychotic disorder patients, while sui-
cidal thoughts and loss of a close person showed trends towards
significance. Two factors characterized classification of outcome:
adaptation difficulties and family problems. A “high-functioning”
factor was significantly higher within the control group, while a