European Psychiatry - Volume 41 - April 2017

867 / 916

25th European Congress of Psychiatry / European Psychiatry 41S (2017) S847–S910 S863
Objective To determine the impact of HBV/HCV co-infection on
the long-term survival of schizophrenic patients with co-occurring
substance use disorders.
Methods Charts of 223 subjects admitted from January 1, 2002 to
May 31, 2006 were assessed. The Kaplan–Meier survival analysis
was used to estimate the cumulative survival rates. The associ-
ation between HBV/HCV and mortality was estimated using the
Cox proportional-hazard regression models, with adjustments for
potential confounders. The main outcome was all-cause mortality.
Median observation time was 10.3 years.
Results Total all-cause 11 year, unadjusted mortality was 18.0%
in population with no viral hepatitis (VH) infection (n = 185;
83.0%), 66.7% in population with HBV monoinfection (n = 3;
1.3%), 50.0% in population with HCV monoinfection (n = 28;
12.6%), and 64.3% in population with HBV/HCV co-infection
(n = 7; 3.1%), P < 0.00001. In Cox regression, the adjusted haz-
ard ratio was 4.22 (95% CI: 1.00–18.63; P< 0.05) for the
HBV, 4.24 (95% CI: 2.13–8.47; P < 0.00001) for the HCV, 6.18
(95% CI: 2.01–19.01; P < 0.0015) for the HBV/HCV, all vs. no
VH-infection.
Conclusions The high mortality of schizophrenic dual disorders
patients with HBV/HCV necessitates new approaches to secondary
and tertiary prevention to reduce the burden of chronic liver dis-
ease and to improve survival. The strong adverse effect of HBV/HCV
on survival should encourage clinical trials including schizophrenic
dual disorders patients on whether patients benefit from treat-
ment choices. It is essential that adequate resources and strategies
are targeted to the schizophrenic dual disorders patients with
HBV/HCV.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1395
Increased intake of monosaccharides
and disaccharides in opioid-addicts
E.J. Gorzela ´nczyk ∗ zponar alecki
1 Nicolaus Copernicus University, Medical College, Department of
Theoretical Biomedical Sciences and Medical Informatics, Bydgoszcz,
Poland
2 Jagiellonian University Medical College, Faculty of Medicine,
Krakow, Poland
∗ Corresponding author.
Introduction Persons dependent on opioids often characterized
by the coexistence of a whole range of dysfunctional behaviors,
which may also lead to eating disorders.
Objectives Impulsive and risky behavior, conducive to the for-
mation of polysubstance dependence, including food addiction,
which manifests itself in the uncontrollable craving substances,
that are quickly metabolized and turned into sugar in the
bloodstream.
Aims Aim of the study was to assess the nutritional status
and carbohydrates consumption in opioid-dependent individuals
treated with methadone substitution therapy.
Methods Fourteen opioid addicts during methadone mainte-
nance treatment were examined. Eighteen healthy individuals
matched for age and gender were included to the control group.
The 24 hour hour diet recalls interview was used. After the dietary
recall, a special questionnaire was administered to ascertain fre-
quency of refined carbohydrates consumptions during the past
30 days.
Results It was found the nutritional deficiencies in the diet and
poor nutritional status in opioid-addicts compared to healthy
ones. Opioid-dependent individuals significantly more often snack
between meals. It was found increased consumption monosaccha-
rides and disaccharides in foods and beverages in opioid-addicts
compared to healthy ones (P < 0.05).
Conclusions Investigation of dietary behaviors may facilitate
understanding of dynamics of addiction, so that we can use more
effective methods of treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1396
The cat and the mouse game: Is there
a shift towards more dangerous
substances in the cathinone illicit
market?
M. Grifell ∗, L. Galindo , M. Ventura , E. Ribera , P. Quintana ,
A. Palma , X. Carbón , L. Gonzalez , L. San-Emeterio ,
C. Diez-Aja , F. Caudevilla , M. Torrens
1 Parc de Salut Mar, Institut de Neuropsiquiatria i Addiccions,
Barcelona, Spain
2 ABD, Energy Control, Barcelona, Spain
∗ Corresponding author.
Introduction After mephedrone’s ban in March 2010 new
cathinones proliferated widely, even a new branch of atypi-
cal derivatives was launched into the market, represented by
MDPV. The cardiovascular and central nervous system toxicity
draws attention to this new family of cathinones, also known as
pyrovalerones. MDPVwas scheduled in 2011, leading to the appari-
tion of Alpha-PVP from which there is little information.
Objectives The aim of the present study is to describe the evolu-
tion of different cathinones in the samples delivered for analysis to
the harm reduction NGO energy control fromMarch 2009 to March
2016 in Spain.
Methods Energy control is a Spanish harm reduction NGO that
offers to drug users the possibility of analyzing the substances
they intend to consume. From March 2009 to March 2016 a
total of 24,528 samples were analyzed by the NGO from which
760 contained cathinones. Substance analysis was done by gas
chromatography–mass spectrometry.
Results From 2009 to 2016, cathinones represented a 2.82% from
all analyzed samples. From March 2009 to March 2010, only 5 dif-
ferent cathinones were detected, in this same period methylone
(n = 16; 37.20%) and mephedrone ( n = 17; 39.53%) represented 76%
of analyzed cathinones (n = 43). From March 2015 to March 2016,
132 cathinones were detected: methylone and mephedrone rep-
resented only 19.69%, giving prominence to clephedrone (n = 25;
18.93%) and Alpha-PVP (n = 24; 18.18%).
Conclusions The evolution of synthetic cathinones detected by
energy control is consistent with the evolution described in the
literature. From 2009 to 2016, the cathinones detected diversify
and new substances with higher toxicity potential appear.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1397
Is cloninger type 1 and type 2
alcoholism differ in terms of emotion
regulation?
D. Gulec Oyekcin∗ urgen
Canakkale Onsekiz Mart University Medical Faculty, Psychiatry,
Canakkale, Turkey
∗ Corresponding author.
Introduction Emotional disturbances are a central characteristic
of many mental disorders, including alcohol addiction.
Objectives In this study we aimed to investigate the emotion
disregulation among alcohol use disorders and to compare the
emotion regulation difficulties with type 1 and type 2 alcoholism.