European Psychiatry - Volume 41 - April 2017

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S866 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S847–S910
Target substances of the request of weaning are respectively:
the buprenorphin (58.87%), benzodiazepines (12.63%), the tri-
hexyphenidyl (7.71%), the alcohol (5.61%), the cannabis (5.26%).
A pathological personality was raised in 17.5%.
A psychiatric comorbidity was found to 8% of the patients.
The coverage is made on 3 shutters: biological by the symptomatic
treatment of the weaning and the comorbidities, psychological and
social by the social and occupational reintegration thanks to non-
governmental organizations.
Conclusion Addictology is a stigmatized speciality in Tunisia, by
the peculiarity of the patients and the slowness of the results. Nev-
ertheless the number of consultants does not stop increasingwhere
from the interest to create more specialized services and structures
of rehabilitation.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1404
Nalmefene against alcohol use
disorder: A report of one case
M. Juncal Ruiz ∗ , O. Porta Olivares , L. Sánchez Blanco ,
R. Landera Rodríguez , M. Gómez Revuelta ,
G. Pardo de Santayana Jenaro , R. Martín Gutiérrez ,
E. López García , R. Medina Blanco , L. García Ayala
1 Hospital Universitario Marqués de Valdecilla, Psychiatry,
Santander, Spain
2 Hospital Universitario de Álava-Sede Santiago, Psychiatry,
Vitoria-Gasteiz, Spain
∗ Corresponding author.
Introduction Alcohol consumption represents a significant factor
for mortality in the world: 6.3% in men and 1.1% in women. Alcohol
use disorder is also very common: 5.4% in men and 1.5% in women.
Despite its high frequency and the seriousness of this disorder,
only 8% of all alcohol-dependents are ever treated. One potentially
interesting treatment option is oriented toward reducing alcohol
intake.
Aims To describe one case who has improved his alcohol con-
sumption after starting treatment with nalmefene, an opioid
receptor antagonist related to naltrexone.
Methods A35-year-oldmalewith alcohol use disorder since 2001
came to our consult in November 2015. He was in trouble with his
family and he had a liver failure. We offer a new treatment option
with nalmefene 18mg to reduce alcohol consumption.
Results Before to start nalmefene he drank 21 drinks/week. Six-
month later, he decreased alcohol intake until 5 drinks/week with
better family relationship and liver function. After starting nalme-
fene he complained of nausea, sowe recommend to take themiddle
of the pill for next 7 days. After this time he returned to take one
pill with good tolerance and no more side effects or withdrawal
syndrome.
Conclusions Nalmefene appears to be effective and safe in reduc-
ing heavy drinking and in preventing alcohol withdrawal syndrome
due to its opioid receptor antagonism. This case suggests nalmefene
is a potential option to help patients, who do not want or cannot
get the abstinence, in reducing their alcohol consumption.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1405
The royal road to the obesity: A case
report of food addiction
A. Kandeger ∗, H. Bozkurt
1 Selcuk University, Department of Psychiatry, Konya, Turkey
2 Gaziosmanpasa University, Department of Child and Adolescent
Psychiatry, Tokat, Turkey
∗ Corresponding author.
Increasing prevalence of obesity in the world and increasing role
of processed foods in daily life has led to become the focal point of
food addiction. In recent years, the animal studies and human brain
imaging studies demonstrated the neurobiological and behavioral
similarities between drug addiction and food addiction. Here, we
aim to present a 13-year-old, female, adolescent who applied with
complaints of anger and irritability and shows serious addictive
behaviors of chocolate. Our patient with increasing chocolate con-
sumption in the last two years was using atomoxetine 60mg/day
with attention deficit hyperactivity disorder (ADHD). She gradu-
ally needs more chocolate to be satisfied. She has complained of
nervousness, irritability and serious chocolate-seeking behavior
during chocolate deprivation. She gained weight in proportion to
the increase in chocolate consumption. Her daily diet was increas-
ingly deteriorated. We used behavioral approach and sertraline in
her treatment and were observed that partially benefit from treat-
ment. Combined data from retrospective accounts of adults and
prospective observations of youth indicates that juveniles with
ADHD are at increased risk for cigarette smoking and substance
abuse and behavioral addiction such as Internet addiction, gam-
bling and sex addiction during adolescence. Recognition of the food
addiction is important to fight against obesity, strengthening the
treatment of choice in the food addiction and take political mea-
sures against food addiction are becoming inevitable.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1406
Chronic methiopropamine modifies
preference of choice in rat gambling
task
H.S. Yoon , W.Y. Kim , M.J. Ku , B.R. Cho , M.J. Kwak , J.H. Kim ∗
Yonsei University College of Medicine, Physiology, Seoul, Republic of
Korea
∗ Corresponding author.
Introduction and aims Rat gambling task (rGT) is a recently
developed animal model making translational research possible in
psychiatric disorders related to decision-making deficits. Methio-
propamine (MPA) is a structural analog to methamphetamine and
a temporary controlled substance. Although increasing concerns
have been raised regarding MPA’s abuse, few sources of informa-
tion exist regarding its psychopharmacology. Thus, we investigated
whether MPA produces any changes in the choice of preference in
rGT.
Methods Rats were trained in a touch screen chamber to learn
the relationships between 4 different light signals on the screen
and accompanied reward outcomes and punishments set up with
different schedules, for one session of 30min each day. Once ani-
mals showed a stabilized pattern of preference, they were given a
total of 5 IP injections (a single injection per day, every other day)
with saline or MPA followed by 2 weeks of withdrawal. Upon MPA
challenge injection, their preference of choice was re-tested in rGT
chambers.
Results Depending upon their preference of choice, rats were
separated as risk-averse or risk-seeking groups. When they were
pre-exposed to and challenged with MPA, rats in the risk-averse
group significantly changed their preference toward more disad-
vantageous choices. These effects were not shown when they were
pre-exposed to saline and challenged with MPA.
Conclusions These results indicate that MPA badly influences
decision-making behavior as in gambling task, implying that it
may aggravate pathological symptoms of bad choices, resulting in