European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S847–S910 S867
negative consequences, observed in the patients with behavioral
addictions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1407
Identifying the relationship between
marital adjustment and, sex roles and
burnout rather than dependence
features of the patient in wives of the
patients with AUD
A. Kokurcan ∗, K. Nazan , ˙I.Ö. ˙Ilhan
1 Dıskapı Yıldırım Beyazıt Education and Research Hospital,
Psychiatry, Ankara, Turkey
2 Ankara University, Psychiatry, Ankara, Turkey
∗ Corresponding author.
Objective To identify the relationship between marital adjust-
ment and, sex roles and burnout rather than dependence features
of the patient in wives of the patients with AUD.
Method The study sample consisted of 33 wives of AUD patients
(according to DSM-IV-TR criteria) who were applied to a Uni-
versity Hospital Alcohol Dependence Clinic to leave alcohol use.
Sociodemographic questionnaire, Marital Adjustment Scale (MAS),
Maslach Burnout Inventory (MBI), Bem Sex Role Inventory-Short
Form (BSRI) and, Beck Depression Inventory (BDI) were applied to
the wives of ADD patients.
Results Mean MAS score was under cut-off score (29.63 ± 10.33)
and it shows that marital adjustment is lower in wives of ADD
patients. It was shown that marriages longer than ten years, and
higher emotional exhaustion scores were associated with lower
marital adjustment in our study. Masculinity scores were higher
in wives who perceived their income status higher. In contrast to
previous studies, which examined marital adjustment, masculinity
role was found to be associated with higher marital adjustment in
our study.
Discussion Emotional exhaustion and depression are common
in spouses of the patients with ADD in our study. There may
be a distortion in expected roles of the spouses which cause
a disequilibrium on the family relationship. Lower income sta-
tus, having increased number of children was associated with
severe depression in wives which found to reduce marital adjust-
ment scores. Finally, most of the wives of ADD patients will need
psychotherapeutic treatments during addiction period. So incor-
porating spouses into treatment of ADD patients is a necessity to
improve marital adjustment and burnout.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1408
Interventions to improve lifestyle and
quality of life in patients with
concurrent mental illness and
substance use
A. Juel . Kristiansen ∗ unk-Jørgensen jorth
1 Aarhus University Hospital, Department of Affective Disorders,
Randers NO, Denmark
2 Southern University of Denmark, Department of Psychiatry, Odense,
Denmark
3 Psychiatric Hospital Randers, Mental Health Center, Randers,
Denmark
∗ Corresponding author.
Background Patients with co-existence of psychiatric disorders
and substance use have an increased risk of premature death. This
is attributable to a higher prevalence of physical comorbidities and
the lifestyle related to substance use. Furthermore, they experience
low quality of life (QoL). Studies addressing lifestyle interventions
for these patients are warranted.
Aims To investigate the physical health and QoL in patients with
co-existence of psychiatric disorders and substance use, and to
analyse for changes in their (a) health, (b) substance use and (c)
QoL after a 24-month health-promotion programme. Further aims
were to investigate associations between (a) QoL and number of
interventions, (b) QoL and patient characteristics and (c) QoL and
length of participation in the intervention.
Methods In this naturalistic cohort study, 64 non-selected
patients were engaged in health-promoting interventions added
to contemporary treatments. QoL and clinical variables were mea-
sured at the beginning of and continuously during the programme
by means of the WHOQoL-Bref questionnaire.
Results At enrolment, the patients’ intake of cannabis and
alcohol was high. During follow-up, patients consumed signifi-
cantly fewer caffeinated beverages (P = 0.038) and fast-food meals
(P = 0.018), and slept significantly less (P = 0.032). The average
dose of antipsychoticmedication increased significantly (P = 0.015).
QoL was low at enrolment but improved significantly overall
(P = 0.009) and in the psychological (P= 0.020) and environmen-
tal domains (P = 0.012) at follow-up. The difference in total
QoL was positively associated with the number of interventions
attended.
Conclusion This programme shows promise in addressing health
promotion for these patients and can easily be integrated into con-
temporary treatments.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1409
Clock genes SNP array identifies a key
role of the PER1/HES7 gene in the risk
of cannabis addiction and psychiatric
comorbidities
G. Lafaye∗, A. Benyamina
Hôpital Paul-Brousse, Addictologie, Villejuif, France
∗ Corresponding author.
The existence of biological rhythms disruption in addicted sub-
jects has been described including disturbances in their sleep-wake
pattern, rest-activity rhythms, and feeding schedules. Circadian
rhythms have also been related to psychiatric diseases, including
mood and anxiety disorders and the regulation of dopaminergic
transmission, especially in reward circuitry in substance abusers.
The relationship between them remained enigmatic and no data on
the role of clock genes variants on cannabis dependence have been
documented. We aimed at exploring the role of clock gene geno-
types as potential predisposing factor to cannabis addiction, using
a high throughput mass spectrometry methodology that enables
the large-scale analysis of all the known clinically-relevant poly-
morphisms of the core human clock genes. We have conducted
a case-control study on 177 Caucasians categorizing between
cannabis-addicted subjects (n = 83) and casual cannabis consumers
(n = 94). We report here a strong association between the TT* geno-
type RS1442849 inPER1/HES7 gene and a significantly higher risk of
vulnerability to be dependent to cannabis. Moreover, this SNP was
overrepresented in the subsets of cannabis users with more severe
characteristics like personal psychiatric history, unemployed sta-
tus, and beginning of cannabis use early in lifetime as well as
large weekly consumption. HES7 gene is a newly described gene
with a circadian expression regulated by reactive oxygen species in
many cell types including neural stem cells. The HES7 TT* genotype
RS1442849 gene could intervene on the dopamine reward systems.
This genotype thus represents the first potential biomarker for