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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S106–S169

functioning and on attention, memory, executive functioning, and

social cognition.


In KBG patients, mild to moderate intellectual disabili-

ties (WAIS IV Total IQ = 63.5


10.7, range: 45–84) were established

with a mental age that was lower than mean chronological age



2.6 years versus 11


5.7 years, respectively). When com-

pared to both control groups, results indicated a relatively strong

processing speed and social cognitive functioning of patients with

KBG while direct recall of auditory memory was relatively poor

most probably due to attentional dysfunction.


The cognitive profile of this group of 17 patients with

KBG is characterized by mild intellectual disability and diminished

sustained attention in verbal tasks. Implications for diagnostic pro-

cedures and clinical management of the syndrome are discussed,

also with regard to the question how this relates to classificatory

diagnosis of ADHD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Deaf blindness and mental

health – Prevalence of Mental

disorders of an upper Austrian

outpatient service

M. Fellinger

1 ,

, E. Sacherer


, J. Fellinger



Medical University of Vienna, Psychiatry and Psychotherapy,

Vienna, Austria


Hospital of St. John- Linz, Institute for Neurology of Senses and

Language, Linz, Austria

Corresponding author.


People with deaf blindness are a vulnerable group

concerning mental health problems. Due to their constraints in ori-

entation, mobility, access to information and communication they

often suffer from a lack of interpersonal relationships and accessi-

bility to health care.


To assess the prevalence of mental disorders in patients

with deaf blindness and exam associations with forms of commu-



A retrospective data evaluation of all outpatient charts

of patients treated between 2000–2013 in a specialized outpatient

unit that provides primary care for all deaf people for the whole

catchment area of Upper Austria was conducted. Data were ana-

lysed regarding the degree of visual and hearing impairment and

the presence of a mental disorder.


Forty-seven of 1500 patients were identified as deaf blind

including 12 suffering from Usher Syndrome. Of those 29 (61.7%)

were at least once diagnosed with a mental disorder, most fre-

quently with a mood disorder (MD) (F30–F39) in 40.4%; an anxiety,

stress-related, somatoform disorders (AD) (F40–F49) in 12.8% and

a schizophrenia, schizotypal and delusional disorders (F20–F29) in

10.6%. Deaf blind patients suffered compared to deaf patients more

often from a MD (40.4% vs.11.3%) however less often from a AD

(12.8% vs. 32.6%). No significant association between the form of

communication and being diagnosed with a mental disorder could

be found.


Patients with deaf blindness suffer to a high extend

from mental disorders, especially MDs. It is of utmost importance

to reduce the burden of this population and improve access to spe-

cialized services to diminish isolation as major risk factor.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Anxious distress is associated with

increased immune dysregulation in

patients with major depressive


R. Gaspersz

1 ,

, F. Lamers


, G. Wittenberg


, A. Beekman



A. van Hemert


, R. Schoevers


, B. Penninx



VUMC, Psychiatry, Amserdam, The Netherlands


Janssen Research & Development- LLC, Neuroscience, Raritan New

Jersey, USA


Leiden University Medical Center, Psychiatry, Leiden, The



University Medical Center Groningen, Psychiatry, Groningen, The


Corresponding author.


Although depression with anxious distress appears

to be a clinically relevant subtype of Major Depressive Disor-

der (MDD), whether it involves specific pathophysiology remains

unclear. Inflammation has been implicated, but not comprehen-

sively studied. We examined within a large MDD sample whether

anxious distress and related anxiety features are associated with

differential basal inflammation and innate cytokine production



Data are from 1078 MDD patients from the Nether-

lands study of depression and anxiety. Besides the DSM-5 anxious

distress specifier, we studied various dimensional anxiety scales

(e.g. Inventory of Depressive Symptomatology anxiety arousal sub-

scale [IDS-AA], Beck Anxiety Inventory [BAI], Mood and Anxiety

Symptoms Questionnaire Anxious Arousal scale [MASQ-AA]). Basal

inflammatorymarkers includedC-reactive protein, interleukin (IL)-

6 and tumor-necrosis factor (TNF)- . Innate production capacity

was assessed by 13 lipopolysaccharide (LPS)-stimulated inflamma-

tory markers. Basal and LPS-stimulated inflammation index scores

were created.


Basal inflammation was not associated with anxious dis-

tress in MDD patients (anxious distress prevalence 54.3%), except

for modest positive associations for IDS-AA and BAI scores. How-

ever, anxious distress was associated with higher LPS-stimulated

levels (interferon-


, IL-2, IL-6, monocyte chemotactic protein

(MCP)-1, macrophage inflammatory protein (MIP)-1 , MIP-1 ,

matrix metalloproteinase-2, TNF- , TNF- , LPS-stimulated index).

Oher anxiety indicators (number of specifier items and anxi-

ety diagnoses, IDS-AA, BAI, MASQ-AA) were also associated with

increased innate production capacity.


Within a large MDD sample, the anxious distress

specifier was associated with increased innate cytokine production

capacity but notwith basal inflammation. Results fromdimensional

anxiety indicators largely confirm these results. These findings

provide new insight into the pathophysiology of anxious depres-


Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Psychiatric disorders in adults with

intellectual disabilities: A preliminary

study of prevalence and associated


A. Görmez

1 ,

, K .




Istanbul Medeniyet University, Psychiatry, Istanbul, Turkey


Bezmialem Vakif University, Psychiatry, Istanbul, Turkey

Corresponding author.