European Psychiatry - Volume 41 - April 2017

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S158 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S106–S169
functioning and on attention, memory, executive functioning, and
social cognition.
Results In KBG patients, mild to moderate intellectual disabili-
ties (WAIS IV Total IQ = 63.5 ± 10.7, range: 45–84) were established
with a mental age that was lower than mean chronological age
(6.4 ± 2.6 years versus 11 ±5.7 years, respectively). When com-
pared to both control groups, results indicated a relatively strong
processing speed and social cognitive functioning of patients with
KBG while direct recall of auditory memory was relatively poor
most probably due to attentional dysfunction.
Conclusions The cognitive profile of this group of 17 patients with
KBG is characterized by mild intellectual disability and diminished
sustained attention in verbal tasks. Implications for diagnostic pro-
cedures and clinical management of the syndrome are discussed,
also with regard to the question how this relates to classificatory
diagnosis of ADHD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0158
Deaf blindness and mental
health – Prevalence of Mental
disorders of an upper Austrian
outpatient service
M. Fellinger ∗, E. Sacherer , J. Fellinger
1 Medical University of Vienna, Psychiatry and Psychotherapy,
Vienna, Austria
2 Hospital of St. John- Linz, Institute for Neurology of Senses and
Language, Linz, Austria
∗ Corresponding author.
Introduction People with deaf blindness are a vulnerable group
concerning mental health problems. Due to their constraints in ori-
entation, mobility, access to information and communication they
often suffer from a lack of interpersonal relationships and accessi-
bility to health care.
Aims To assess the prevalence of mental disorders in patients
with deaf blindness and exam associations with forms of commu-
nication.
Methods A retrospective data evaluation of all outpatient charts
of patients treated between 2000–2013 in a specialized outpatient
unit that provides primary care for all deaf people for the whole
catchment area of Upper Austria was conducted. Data were ana-
lysed regarding the degree of visual and hearing impairment and
the presence of a mental disorder.
Results Forty-seven of 1500 patients were identified as deaf blind
including 12 suffering from Usher Syndrome. Of those 29 (61.7%)
were at least once diagnosed with a mental disorder, most fre-
quently with a mood disorder (MD) (F30–F39) in 40.4%; an anxiety,
stress-related, somatoform disorders (AD) (F40–F49) in 12.8% and
a schizophrenia, schizotypal and delusional disorders (F20–F29) in
10.6%. Deaf blind patients suffered compared to deaf patients more
often from a MD (40.4% vs.11.3%) however less often from a AD
(12.8% vs. 32.6%). No significant association between the form of
communication and being diagnosed with a mental disorder could
be found.
Conclusion Patients with deaf blindness suffer to a high extend
from mental disorders, especially MDs. It is of utmost importance
to reduce the burden of this population and improve access to spe-
cialized services to diminish isolation as major risk factor.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0159
Anxious distress is associated with
increased immune dysregulation in
patients with major depressive
disorder
R. Gaspersz ∗, F. Lamers , G. Wittenberg , A. Beekman ,
A. van Hemert , R. Schoevers , B. Penninx
1 VUMC, Psychiatry, Amserdam, The Netherlands
2 Janssen Research & Development- LLC, Neuroscience, Raritan New
Jersey, USA
3 Leiden University Medical Center, Psychiatry, Leiden, The
Netherlands
4 University Medical Center Groningen, Psychiatry, Groningen, The
Netherlands
∗ Corresponding author.
Introduction Although depression with anxious distress appears
to be a clinically relevant subtype of Major Depressive Disor-
der (MDD), whether it involves specific pathophysiology remains
unclear. Inflammation has been implicated, but not comprehen-
sively studied. We examined within a large MDD sample whether
anxious distress and related anxiety features are associated with
differential basal inflammation and innate cytokine production
capacity.
Methods Data are from 1078 MDD patients from the Nether-
lands study of depression and anxiety. Besides the DSM-5 anxious
distress specifier, we studied various dimensional anxiety scales
(e.g. Inventory of Depressive Symptomatology anxiety arousal sub-
scale [IDS-AA], Beck Anxiety Inventory [BAI], Mood and Anxiety
Symptoms Questionnaire Anxious Arousal scale [MASQ-AA]). Basal
inflammatorymarkers includedC-reactive protein, interleukin (IL)-
6 and tumor-necrosis factor (TNF)- . Innate production capacity
was assessed by 13 lipopolysaccharide (LPS)-stimulated inflamma-
tory markers. Basal and LPS-stimulated inflammation index scores
were created.
Results Basal inflammation was not associated with anxious dis-
tress in MDD patients (anxious distress prevalence 54.3%), except
for modest positive associations for IDS-AA and BAI scores. How-
ever, anxious distress was associated with higher LPS-stimulated
levels (interferon-γ, IL-2, IL-6, monocyte chemotactic protein
(MCP)-1, macrophage inflammatory protein (MIP)-1 , MIP-1 ,
matrix metalloproteinase-2, TNF- , TNF- , LPS-stimulated index).
Oher anxiety indicators (number of specifier items and anxi-
ety diagnoses, IDS-AA, BAI, MASQ-AA) were also associated with
increased innate production capacity.
Conclusions Within a large MDD sample, the anxious distress
specifier was associated with increased innate cytokine production
capacity but notwith basal inflammation. Results fromdimensional
anxiety indicators largely confirm these results. These findings
provide new insight into the pathophysiology of anxious depres-
sion.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0160
Psychiatric disorders in adults with
intellectual disabilities: A preliminary
study of prevalence and associated
factors
A. Görmez ∗ ˙Ismet
1 Istanbul Medeniyet University, Psychiatry, Istanbul, Turkey
2 Bezmialem Vakif University, Psychiatry, Istanbul, Turkey
∗ Corresponding author.