European Psychiatry - Volume 41 - April 2017

179 / 916

25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237 S175
est among the caregivers of demented subjects who share the same
house.
Conclusion Our findings indicate that the burden experienced by
caregiving family members plays a role in elderly people avoidable
ED visits.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0202
The differential cognitive deficits
between patients with early stage
Alzheimer’s disease and patients with
early stage vascular dementia
J.H. Park ∗, K. Kyung Min , J. Byoung Sun
1 Jeju National University School of Medicine, Jeju National
University Hospital, Psychiatry, Jeju, Republic of Korea
2 Naju National Hospital, Department of Psychiatry, Naju, Republic of
Korea
3 Jeju National University School of Medicine, Jeju National University
Hospital, Department of Psychiatry, Jeju, Jejudo, Republic of Korea
∗ Corresponding author.
Background The study aims to examine whether cognitive
deficits are different between patients with early stage Alzheimer’s
disease (AD) and patients with early stage vascular dementia (VaD)
using the Korean version of the CERAD neuropsychological battery
(CERAD-K-N).
Methods Patients with early stage dementia, global Clinical
Dementia Rating (CDR) 0.5 or 1 were consecutively recruited
among first visitors to a dementia clinic, 257ADpatients and 90VaD
patients completed the protocol of the Korean version of the CERAD
clinical assessment battery. CERAD-K-N was administered for the
comprehensive evaluation of the neuropsychological function.
Results Of the total 347 participants, 257 (69.1%) were AD group
(CDR 0.5 = 66.9%) and 90 (21.9%) were VaD group (CDR 0.5 = 40.0%).
Patients with very mild AD showed poorer performances in Boston
naming test (BNT) (P = 0.028), word list memory test (P < 0.001),
word list recall test (P < 0.001) and word list recognition test
(WLRcT) (P = 0.006) than very mild VaD after adjustment of T
score of MMSE-KC. However, the performance of trail making A
(TMA) was more impaired in VaD group than in AD group. The
performance of WLRcT (P < 0.001) was the worst among neuro-
psychological tests within AD group, whereas TMA was performed
worst within VaD group.
Conclusions Patients with early-stage AD have more cognitive
deficits on memory and language while patients with early-stage
VaD showworse cognitive function on attention/processing speed.
In addition, as the first cognitive deficit, memory dysfunction comes
in AD and deficit in attention/processing speed in VaD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0203
The effectiveness and long-term
prognosis of the intravenous course of
cerebrolysin in patients with the
amnestic MCI
E. Ponomareva
Mental Health Research Center of RAMS, Alzheimer disease and
Related Disorders Research Center, Moscow, Russia
Early diagnosis and treatment in the predementia stage of
Alzheimer’s disease, i.e. in amnestic MCI (aMCI) may improve
patient quality of life and promote slowing of conversion to demen-
tia. The purpose of the study was to analyze the effectiveness
and long-term prognosis of the course of cerebrolysin therapy in
aMCI patients. Twenty elderly aMCI patients were included in the
study and treated with a 20-day course of therapy with daily intra-
venous infusions of 30mL cerebrolysin. Cognitive functions were
assessed by the battery of neuropsychological scales and tests:
MMSE, MoCA-test, МDRS, the Boston naming test, the Clock Draw-
ing Test, Frontal Assessment Battery, the test “10 words”, the Digit
Repetition Test. The level of the auto-antibodies to a short peptide
fragment of the neurotrophins P75 receptor has been investigated
by ELISA in the patient blood serum 3 times per 6months (0, 10
and 26 weeks). Analysis of the data showed a statistically sig-
nificant improvement in psychometric tests at the therapy end
and also at 10 and 26weeks of the study. Long-term therapeu-
tic effect (5months) proved to be significantly correlating with
the following parameters: patient’s age older than 70 years, basic
indices of the MoCA-test and the test “memory” of the dementia
Matisse scale. The decline serum level of autoantibodies to the
fragment 155–164 receptor of neurotrophins P75 also provided
to be an indicator of the long-term effectiveness of the therapy.
These results could determine those aMCI patients who could
have positive long-term therapeutic effect following cerebrolysin
treatment.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW0204
Risk factors of increased mortality
during hospitalization in acutely-ill
elderly patients with altered state of
consciousness
P. Sá Esteves ∗, D. Loureiro , E. Albuquerque , F. Vieira ,
L. Lagarto , S. Neves , J. Cerejeira
1 Centro Hospitalar e Universitário de Coimbra, Psychiatry, Coimbra,
Portugal
2 Centro Hospitalar de Entre o Douro e Vouga, Psychiatry, Santa
Maria da Feira, Portugal
∗ Corresponding author.
Introduction A significant proportion of acutely ill hospitalised
elderly patients have impaired consciousness and this has been
associated with increased mortality. It remains unclear which fac-
tors underlie this relation. Identification of mortality predictors in
this population is important to improve care.
Objectives Determine if advanced age, cognitive impairment,
high burden of co-morbidities and poor functional status are pre-
dictors of increased mortality during hospitalisation in acutely-ill
medical hospitalised elderly patients with altered state of con-
sciousness.
Methods All male patients (> 65 years) admitted to a medical
ward (> 48 h) between 01/03/2015 to 31/08/2015 with delirium
or RASS lower than–2 were included in the study. Patients were
excluded if unable to be assessed due to sensorial deficits, commu-
nication problems or medical condition precluding the evaluation.
Baseline evaluation included socio-demographic variables, RASS,
CAM, IQCODE-SF, DSM-IV-TR criteria for dementia, Charlson Co-
morbidity Index and Barthel Index. The variables were entered in
a logistic regression model (significance level < 0.05).
Results The final sample consisted of 75 male subjects with
altered state of consciousness, 14 of them died during hospitali-
sation. Dementia and Barthel Index were significantly associated
with mortality during hospitalisation (P = 0.01 and P < 0.01, respec-
tively). On the other hand, age and Charlson Co-morbidity Index
were not associated significantly with mortality during hospitali-
sation (P = 0.22 and P= 0.1, respectively).
Conclusions Acutely ill elderly patients with altered state of
consciousness at admission have higher risk of death during hos-
pitalisation if they have prior dementia or poor functional status.