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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S8–S52


Major depressive disorder (MDD) is a common psy-

chiatric condition, affecting up to 350million people worldwide. Its

pathogenesis seems to involve dysregulation of the hypothalamic-

pituitary (HPA) axis and inflammation as key elements of the

condition. Stressful life events and in particular early life adversity

seem to play an important role as risk factors for MDD. Epige-

netic, which has been found to impact in the transcription of genes,

seem to be associated with brain structure and function. Aim of the

research was to provide an overview about neuroimaging (epi)-

genetics in MDD.


Functional MRI, epigenetic and genetic informationwas

obtained in a cohort of patients with MDD and healthy controls.

Associations between, early life adversity, methylation of FKBP5

and SLC6A4, genetic variants and brain function and connectivity

have been analysed.


Higher methylation of SLC6A4 gene was associated with

higher BOLD response during emotion processing and lower BOLD

response during higher order cognitive processes. Healthy partici-

pants with higher SLC6A4 methylation involved prefrontal cortical

regions to a greater extent than the participants with lower SLC6A4

methylation, when trying to switch attention away from negative

emotional stimuli (Frodl et al., 2015). Moreover, FKBP5 methyla-

tion was association with HPA axis functioning and amygdala brain

function in patients withMDD. FKBP5methylation also was related

to grey matter volume.


Our study provides further support to the hypothe-

sis that DNA methylation plays a role. Particular peripheral DNA

methylation states of MDD candidate genes are associated with

brain function during emotion processing in patients with MDD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Disadvantage of social sensitivity:

interaction of oxytocin receptor

genotype and child maltreatment on

brain structure

U. Dannlowski

University of Münster, department of psychiatry, Münster, Germany


Oxytocin has receivedmuch attention as a pro-social

and anxiolytic neuropeptide. In human studies, the G-allele of a

common variant (rs53576) in the oxytocin receptor gene (


) has

been associated with protective properties such as reduced stress

response and higher receptiveness for social support. In contrast,

recent studies suggest a detrimental role of the rs53576 G-allele in

the context of childhood maltreatment. To further elucidate the

role of


, gene by maltreatment (GxE) interactions on brain

structure and function were investigated.

Methods n

= 309 healthy participants genotyped for


rs53576 underwent structural as well as functional MRI during a

common emotional face-matching task. Childhood maltreatment

was assessed with the Childhood Trauma Questionnaire (CTQ).

Gray matter volumes were investigated by means of voxel-based

morphometry (VBM) across the entire brain.


Structural MRI data revealed a strong interaction of

rs53576 genotype and CTQ-scores, mapping specifically to the

bilateral ventral striatum. GG homozygotes but not A-allele

carriers showed strong gray matter reduction with increasing CTQ-

scores. In turn, lower ventral striatum gray matter volumes were

associated with lower reward dependence, a pro-social trait. Fur-

thermore, the G-allele was associated with increased amygdala

responsiveness to emotional facial expressions.


The findings suggest that the G-allele constitutes a

vulnerability factor for specific alterations of limbic brain structure

in individuals with adverse childhood experiences, complemented

by increased limbic responsiveness to emotional interpersonal

stimuli. While oxytocinergic signalling facilitates attachment and

bonding in supportive social environments, this attunement for

social cues may turn disadvantageous under early adverse condi-


Disclosure of interest

The author has not supplied his declaration

of competing interest.

Symposium: using technology to respond to the

mental health needs of refugees in europe: mobile

devices, telemedicine, and outcomes management


The use of a telemedicine model and

its logistics to reach as many

european refugees as possible

D. Mucic

The little Prince psychiatry centre, Copenhagen, Denmark

Current refugee crisis challenges mental health care systems all

over the Europe. There is a number of research describing difficul-

ties in dealing with cross-cultural patients. Access to relevant care

as well as its availability are often limited due to: a) lack of respec-

tive qualified resources b) linguistically, cultural and even racial

barriers in addressing of mental health care needs of cross-cultural

patient population. By use of various e-Mental health applications,

primarily videoconference, we may improve assessment and/or

treatment of refugees and asylum seekers on distance e.g. Arabic

speaking psychiatrist located in Sweden would be able to assess

and/or treat refugees from Syria located in Germany). Specialized

centers for treatment of refugees would also be able to get second-

opinion service from remote experts and use it in order to confirm

or re-consider diagnosis as well as the treatment options. Estab-

lishment of international network of cross-cultural experts enables


– Improve the mental health care across national bound-

aries by providing psychiatric consultations to other countries

within EU

– Conduct International Treatment Teamwith Select Skills (e.g. Sign

Language and Many Foreign Languages Staff)

– Provide Distance Supervision and Staff Consultation

– Provide Psycho Education of caregivers

– Improve Distance Learning via Case Conferencing and Best

Practice Demonstration Across the National Boundaries

– Create Data Base over cross-cultural and other select skills pro-

fessionals within EU

Disclosure of interest

The author has not supplied his declaration

of competing interest.


Preliminary results of USA-European

field trial on the use of

patient-reported measures in a

mobile application and potential uses

in refugee populations

W. Narrow

1 ,

, V. Buwalda


, J. McIntyre



University of New Mexico, psychiatry and behavioral sciences,

Albuquerque, USA


Vrije universiteit, psychiatry, Amsterdam, The Netherlands


University of Rochester medical center, psychiatry, Rochester, USA

Corresponding author.