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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S238–S302 S253
to 4.46], group based counseling (SMD 1·36, CrI 0 ·40 to 3·17) had
significantly greater effects than usual care. Participants assigned
to all assessed interventions had a significantly improvement in
depression compared with usual care, except for those assigned to
psychoeducational therapy (SMD 0.02, 95% CrI -0.11 to 0.15).
Conclusion This review shows that cognitive behavioral therapy,
group based counseling and exercise may have significant benefi-
cial effects considering SF-36 and HADS when comparedwith usual
care. However, additional well-done research studies are necessary
to establish the role of psychosocial interventions in men with PCa.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0430
Suicides and cancer mortality in
russia: A comparative analysis of
trends
Y. Razvodovsky
Grodno State Medical University, Pathological Physiology, Grodno,
Belarus
Introduction The association between suicide and cancer is com-
plex. Hopelessness and depression are the common risk factors for
both suicide and cancer. There is also evidence that suicide rate in
cancer patients are higher than in the general population. However,
the real occurrence of suicide in cancer patients is considered to be
underreported. This is a good reason to expect a positive relation-
ship between cancer mortality and suicide rates at the population
level.
Aims The present study aims to test the hypothesis of the close
aggregate level link between cancer mortality and the suicide rates
in Russia.
Methods Trends in sex-specific cancer mortality and the suicide
rates from 1956 to 2010 were analyzed employing a distributed
lags analysis.
Results The results of analysis indicate the presence of a statisti-
cally significant association between trends in suicides and cancer
of the upper digestive tract (mouth, oral cavity and pharynx), lar-
ynx, bronchus and lungs, stomach, colorectal, uretus and leukemia
for male. There is also a statistically significant association between
trends in suicides and cancer of the upper digestive tract (mouth,
oral cavity and pharynx), larynx, bronchus and lungs, stomach, col-
orectal, uretus, breast, cervix, uterus and leukemia for female.
Conclusions Common confounding variables, including binge
drinking and psychosocial distress, may explain positive aggregate-
level association between the cancer mortality and suicides time
series in Russia.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW0431
Clinical and psychological
confirmation of stabilizing effect of
neurofeedback in migraine
O. Dobrushina ∗ Arina sina Aziatskaya
1 International Institute of Psychosomatic Health, Department of
neurorehabilitation, Moscow, Russia
2 Lomonosov Moscow State University, Department of psychology,
Moscow, Russia
∗ Corresponding author.
Introduction Neurofeedback in migraine aims to improve neu-
rophysiological state, which is linked to psychosomatic, emotional
and cognitive regulation. Objective and complex evaluation of neu-
rofeedback effects is feasible.
Methods A single case design cross-over placebo-controlled
study with blinded evaluator included 3 females with frequent
migraine (N., E., T.), 1 of whom (T.) also had TTH. Study had
4 phases: evaluation (≥ 2 weeks), treatment 1 (5 weeks), treat-
ment 2 (5 weeks), evaluation (≥ 2 weeks). Treatment 1 and 2
included 10 infra-low frequency neurofeedback and 10 sham-
neurofeedback sessions at T3T4 site in randomized order. Detailed
psychological assessment was performed a baseline, at phase
switch and in the end. Every day participants filler a com-
puterized diary about pain, aura, mood, stress, copings. Before
each session they received questionnaires “well-being, activity,
mood” (rating of the current state between antonym adjectives, in
Russian).
Results Themain findingwas reduction of migraine (but not TTH)
frequency during real, but not sham neurofeedback phase: 11% vs.
31% days in N. ( P = 0.1), 15% vs. 30% days in E. (P = 0.046), T. After
the start of neurofeedback had only TTH. Another detected phe-
nomena was reduction of day-to-day shifts in cognitive function
domains of “well-being, activity, mood” (easy/difficult to think,
attentive/distracted). In N. and E these domains had co-dynamic
with mood (good/bad mood, happy/sad), while in T. – with anxiety
(tensed/relaxed, nervous/calm).
Conclusion Infra-low frequency neurofeedback from interhemi-
spheric site resulted in decrease in migraine frequency and in
reduction of shifts in psychological state. Thus, the treatment had
multimodal stabilizing effect.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0432
Sham-neurofeedback as an
intervention: Placebo or nocebo?
G. Arina ∗, E. Osina , O. Dobrushina , G. Aziatskaya
1 Lomonosov Moscow State University, Department of psychology,
Moscow, Russia
2 International Institute of Psychosomatic Health, Department of
neurorehabilitation, Moscow, Russia
∗ Corresponding author.
Introduction Sham-controlled studies of neurofeedback are
aimed to provide evidence-based data regarding its efficacy. How-
ever, a sophisticated sham procedure may turn out to be an
intervention rather that a neutral control.
Methods Data from a single-case cross-over sham-controlled
study of NF in migraine were analyzed to access the effects of
sham-NF. The study included 5 females with chronic migraine
and was divided into 4 phases: pre-evaluation (≥ 2 weeks), treat-
ment 1 (5weeks), treatment 2 (5weeks), post-evaluation (≥ 2
weeks), where treatment 1 and 2 included 10 infra-low frequency
NF and 10 sham-NF sessions at T3T4 site in randomized order.
Participants filled out a computerized diary about headache and
emotions.
Results Sham-NF resulted in some reduction of the level of
tension (0.8± 0.7 vs. 1.1 ±0.5, P = 0.1) and anxiety (0.56 ±0.5 vs.
0.95± 0.4, P= 0.07) as measured by the mean value in the diary
(rating from 0 - no emotion, to 3 - very intense). While the total
frequency of headache was not influenced by sham-NF (40 ± 11%
vs. 40 ±7% days, P = 1), a tendency towards an increase in quantity
of severe headaches (42 ± 18% vs. 20± 18% days, P = 0.07) and in
the need for drug intake (74 ±27% vs. 44 ±30% days, P = 0.07) was
observed. We supposed that expectation of feedback and failure to
receive it during sham sessions may have possible negative effects,
while frequent visits to the clinic and contact with the therapist
may explain reduction in anxiety.
Conclusion Sham-NF seems to have both placebo and nocebo
effects, which should be considered during interpretation of results
of the studies.