European Psychiatry - Volume 41 - April 2017

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S306 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S303–S364
Background Atypical anti-psychotics have been found to be
associated with hyperuricemia. The aims of this study were to
determine the prevalence of hyperuricemia and metabolic adverse
events in children and adolescents with ASD treated with risperi-
done.
Methods In this cross-sectional study, we recruited 127 Thai ASD
children and adolescents aged 3–20 years receiving risperidone for
more than 4 weeks. The clinical data and laboratory data were
obtained and analyzed. Hyperuricemia was defined as serum uric
acid > 5.5mg/dL.
Results Hyperuricemia was present in 57.48% of total ASD
patients treated with risperidone. Uric acid levels were signifi-
cantly higher in adolescents as compared to children. Uric acid
levels correlated with risperidone dose ( P = 0.01), duration of treat-
ment ( P < 0.0001), BMI (P < 0.0001), waist circumference (P = 0.003),
triglyceride (TG; P < 0.0001), triglycerides/high-density lipopro-
tein cholesterol ratio (TG/HDL-C; P < 0.0001), insulin (P = 0.04),
homeostatic model assessment index (HOMA-IR; P = 0.03), high-
sensitivity CRP (hs-CRP; P < 0.0001), and leptin levels (P < 0.0001).
HDL-C and adiponectin levels were negatively correlated with uric
acid levels (P < 0.0001). In multiple regressions analysis, age, BMI,
TG/HDL-C, and adiponectin level remained significantly associated
with uric acid levels (P < 0.0001).
Conclusion Hyperuricemia may play a role in metabolic adverse
effects in children and adolescents with ASD receiving high dose
and/or long-term treatment with risperidone.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW0585
Effects of executive function
stimulation in the language
improvement of children with ASD
I. Sun ∗ ernandes
University of São Paulo, FMUSP, São Paulo, Brazil
∗ Corresponding author.
The Autism Spectrum Disorder (ASD) is a neurobiological disorder
that involves deficits currently classified into two areas:.
– social communication and interaction across multiple contexts;
– restricted, repetitive patterns of behavior, interests or activities.
Although, these disorders do not have any causal relationship, both
are always present. It has increasingly been sought methods aiming
at the effectiveness of intervention for this population seeking to
include all aspects. A promising research field is the one that consi-
ders the interdependence of the language and cognition areas,
specifically regarding executive functions. This study was designed
to verify the effectiveness of an executive functions stimulation
program(EFS) during the regular speech-language therapy sessions
and its impact in language development, specifically in the prag-
matic aspects, through the evaluation of the functional profile of
communication (FPC) in 14 children with ASD. During a 12-week
period of regular speech-language therapy, the following areas
were focused: working memory, cognitive flexibility, central cohe-
rence, inhibitory control and specific language aspects. Data were
registered and analyzed statistically. The average performance of
children in the stimulation was 85%, ensuring the effectiveness
of EFS. The association analysis between pre- and post-EFS per-
formance with FCP a significant improvement was observed in
the occupation of the communicative space and the percentage of
interactivity. These results are consistent with the hypothesis of
the study, which believes in strong association between communi-
cation aspects and executive functions skills.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0586
Cytogenetic characteristic the patients
of both sexes with phobic-anxiety
disorders
P.T. ∗, N. Bagatska , E. Mykhailova , L. Glotka ,
N. Reshetovska , T. Matkovska , A. Goloborodko
1 SI “Institute for Children and Adolescents Health Care of the NAMS
of Ukraine”, psychiatry, Kharkiv, Ukraine
2 SI “Institute for Children and Adolescents Health Care of the NAMS
of Ukraine”, genetic, Ukraine Kharkov V. Karazin National University,
Kharkiv, Ukraine
3 SI “Institute for Children and Adolescents Health Care of the NAMS
of Ukraine”, genetic, Kharkiv, Ukraine
∗ Corresponding author.
Background and aims Anxiety-phobic disorders are caused both
by environmental and hereditary factors. The studywas designed to
determine the level of chromosomal aberrations in the peripheral
blood lymphocytes (PBL) of children and adolescents of both sexes
with phobic-anxiety disorders (PAD).
Patients and methods Cytogenetic analysis was performed in
27 children and adolescents of both sexes with PAD, aged
9–15 years; the control group consisted of 50 healthy peers of both
genders. Statistical analysis-Excel and SPSS statistics 17.0.
Results Cytogenetic analysis of patients with PAD and in healthy
age-matched individuals has established normal female (46,XX)
and male (46,XY) karyotypes. The frequency of the chromoso-
mal aberrations (CA) spontaneous level in the PBL is 4.6 times
higher than the CA frequency in healthy persons. In children
and adolescents with the disease, the spontaneous frequency
of aberrations of chromatid and chromosome types is also
significantly higher than the same in healthy children and ado-
lescents. Single acentric fragments and exchanges prevail among
the chromatid–type aberrations; pair acentric fragments prevail
among the chromosome–type aberrations. An increase in the fre-
quency of the chromosome-type aberrations has been revealed in
boys with PAD (1.72 vs.0.55 per100 cells in healthy boys, P< 0.001
by pair acentric fragments), in comparison with healthy boys; and
the chromatid–type aberrations have been observed in girls with
PAD (3.22 vs.0.94 per 100 cells in healthy girls, P < 0.001 by single
acentric fragments), in comparison with healthy girls. A pronoun-
ced individual variability of CA frequency, which ranges in our
patients from 2.0 to18.0 per 100 metaphase plates, has been found
along with an increase in the CA level in patients with PAD.
Conclusion Children and adolescents with PAD require a careful
cytogenetic analysis and the consequent therapeutic measures for
genome stabilization.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0587
Effect of adenotonsillectomy on
attention-deficit/hyperactivity
disorder symptoms, sleep disturbance
symptoms, and quality of life of
children with adenotonsillar
hypertrophy and sleep-disordered
breathing
S. Türkoglu ∗ . Somuk apmaz Goktas ilgic
1 Selcuk university medical faculty, department of child and
adolescent psychiatry, Konya, Turkey
2 Gaziosmanpasa university hospital, department of
otolaryngology-head and neck surgery, Tokat, Turkey
3 Necmettin Erbakan university, department of child and adolescent
psychiatry, Konya, Turkey
∗ Corresponding author.