European Psychiatry - Volume 41 - April 2017

311 / 916

25th European Congress of Psychiatry / European Psychiatry 41S (2017) S303–S364 S307
Objectives To date, limited data has been available regarding the
impact of adenotonsillectomy (AT) on the psychosocial well-being
of chronic adenotonsillar hypertrophy (CAH) subjects.
Aims In the present study, we examined the impacts of AT
on attention-deficit/hyperactivity disorder symptoms (ADHD) and
sleep disturbance symptoms and quality of life of children with
chronic adenotonsillar hypertrophy.
Methods Parents of children with CAH filled in Conners Parent
Rating Scale-Revised Short (CPRS-RS), children’s sleep habits ques-
tionnaire (CSHQ), and the pediatric quality of life inventory, parent
versions (PedsQL-P) before and six months after AT.
Results A total of 64 children were included the study (mean
age: 6.8 ± 2.4 years; 50% boys). Mean ADHD Index (11.98 ±6.94
versus 10.35 ± 6.44) (before AT versus after AT) and oppositional
scores (6.73 ±3.72 versus 5.87 ±3.52) improved statistically signi-
ficantly after AT (P < 0.05). All of the CSHQ subdomain scores, except
sleep duration, significantly reduced after AT (P < 0.05). Regarding
to quality of life, both PedsQL-P physical health (64.20 ± 19.81
versus 69.84 ±18.63) and psychosocial health subdomain scores
(67.83 ±12.89 versus 75.57 ± 13.16), and PedsQL-P total score
(66.57 ±12.94 versus 73.58 ± 12.46) of the patients were signifi-
cantly higher six months after AT (P < 0.001).
Conclusions It is necessary for child and adolescent psychiatrists
to query the symptoms of CAH to identify children with chro-
nic adenotonsillar hypertrophy who suffer from ADHD symptoms,
oppositionality, and sleep disturbance. To carry out AT seems to be
beneficial for coexisting ADHD and sleep disorder symptoms and
quality of life in these children.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0588
Intelligence functioning and
associated factors in children with
cerebral palsy
S. Türkoglu ∗ ürko˘glu elik Ucan
1 Selcuk university, faculty of medicine, department of child and
adolescent psychiatry, Konya, Turkey
2 Konya training and research hospital, physical medicine and
rehabilitation, Konya, Turkey
3 Giresun university, faculty of medicine, department of physical
medicine and rehabilitation, Giresun, Turkey
4 Ankara physical medicine and rehabilitation training and research
hospital, department of physical medicine and rehabilitation, Ankara,
Turkey
∗ Corresponding author.
Objectives Cerebral palsy (CP) is described as a primary disor-
der of posture and movement; however, intellectual impairment is
prevalent in children with CP.
Aim The aim of the present study was to examine the associa-
tionwith intellectual level and grossmotor function, hand function,
type of CP, and the presence of co-morbid disorders in these chil-
dren.
Methods A total of 107 children with CP were included in the
study. Intellectual functions of the children were determined by
clinical assessment, adaptive function of daily life, and individua-
lized standardized intelligence testing. Gross motor function and
hand function of the patients were classified using the gross motor
function classification systemand the bimanual finemotor function
measurements.
Results The mean age of the patients were 8.10 ±3.43 years (age:
2–16 years). During clinical typing, we observed that 80.4% of the
patients were spastic, 11.2% were mixed, 4.7% were dyskinetic,
and 3.7% were ataxic. No significant relationship was determi-
ned between the type of CP and intellectual functioning (P > 0.05).
Intellectual functioning was found to be significantly correlated
negatively with both gross motor function and hand functions
level (P < 0.001). The factors related to intellectual functioningwere
neonatal convulsion (x2 = 12.97, P = 0.002), epilepsy (x2 = 29.221,
P < 0.001), and speech disorders (x2 = 23.29, P < 0.001).
Conclusions There is an association between intellectual func-
tioning in children with CP and the degree of motor impairment,
neonatal convulsion, epilepsy, and speech disorders. Intelligence
assessment should be an essential part of CP evaluation.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0589
Methylation related to perceived
parenting in adolescents and its
association to depressive symptoms
two years later
E. Van Assche ∗, E. Vangeel , K. Freson , K. Van Leeuwen ,
K. Verschueren , H. Colpin , W. Van den Noortgate ,
L. Goossens , S. Claes
1 KU Leuven, neuroscience, Leuven, Belgium
2 KU Leuven, center for molecular and vascular biology, Leuven,
Belgium
3 KU Leuven, parenting and special education, Leuven, Belgium
4 KU Leuven, school psychology and child and adolescent
development, Leuven, Belgium
5 KU Leuven, methodology of educational sciences, Leuven, Belgium
∗ Corresponding author.
Introduction Adolescents’ well being is affected by their paren-
ting situation and can influence their well being over time. We
present an exploratory study with an Illumina 450 k array, compa-
ring methylation in adolescents, based on perceived parenting at
T0, and how methylation can interact with parenting in explaining
depressive symptoms two years later (T2).
Objectives Identify differentially methylated regions (DMRs)
associated with perceived parenting at T0 and investigate their
association with depressive symptoms two years later.
Aims An exploratory analysis evaluating the association between
methylation and depressive symptoms longitudinally.
Methods From two extreme parenting clusters: perceived sup-
portive, and punishing neglecting, we randomly selected 44
adolescents (M Age = 14 at T0; 48%boys). The CES-D scale (Center
for Epidemiologic Studies Depression Scale) assessed depressive
symptoms. DMRs were identified based on the parenting clusters
(DMRcate and comb-p) using llumina InfiniumHumanMethylation
450 BeadChip data. Associations between the most significant CpG
for each DMR and the depression score at T2, were calculated using
linear regression analysis.
Results We identified 17 DMRs, but only cg13306335 in PEX10
was associated with depressive symptoms at T2 (P = 0.0014, Bon-
ferroni (17 tests): P < 0.0029). Additionally, an interaction between
parenting at T 0 and PEX10 methylation (T0) in explaining depres-
sive symptoms (T 2) can be suggested (P = 0.014).
Conclusions We show that methylation at PEX10’s most signi-
ficant CpG is correlated with depressive symptoms at T2, these
exploratory results also suggest a possible interaction between
parenting and PEX10 methylation at T0 in association with depres-
sive symptoms at T2 . Validation in a larger sample is needed to
support the role of methylation and its interactions in depression
over time.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.