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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S303–S364


To determine whether the choice of anesthetic drugs in the

case of switching influences the effect on the Hamilton depression

rating scale.


We collected data of patients who received ECT for

therapy resistant depression over the past five years. Choice of

anesthetics, eventually switch and the score on the HDRS before

and after ECT were included. The data was statistical analyzed.


50 patients received ECT during past 5 years. ECT gives

an improvement on the HDRS in all cases, whether there was a

switch or not. Switching from methohexital to ethomidate when

shock duration is less than 21 seconds gives a significant difference

in improvement on the HDRS (BI 1.288 to 13.538) compared to

patients who did not switch.


There are no significant differences on HDRS effect

between the different anesthetics. Switching frommethohexital to

ethomidate gives a significant improvement on HDRS compared

with no switch.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Intrinsic functional connectivity of


ganglia-thalamo-cortical circuitry

underlying psychomotor retardation

in major depressive disorder

Y. Yin

1 ,

, Y. Yuan


, L. Fan


, C. Xie


, Z. Zhang



Affiliated ZhongDa hospital, institute of neuropsychiatry, Southeast

university, department of psychosomatics and psychiatry, school of

medicine, Nanjing, China


Institute of automation, Chinese academy of sciences, Brainnetome

center, Beijing, China


ZhongDa hospital, school of medicine, Southeast university,

neurology, Nanjing, China

Corresponding author.


Psychomotor retardation (PMR) in depression is

analogous to the hypokinesia in Parkinson’s disease, which is

associated with the unbalanced direct and indirect pathways of

cortico-basal ganglia-thalamo-cortical (CBTC) circuitry. This study

hypothesized PMR in major depressive disorder (MDD) should be

associated with the hyperactivity of CBTC indirect pathways.


To substantiate the hypothesis that the PMR symp-

tom of MDDmight attribute to the hyperactivity of the ortico-basal

ganglia-thalamo-cortical indirect pathwaywhich could inhibit psy-

chomotor performance.


We investigated the intrinsic stiato-subthalamic

nucleus (STN)-thalamic functional connectivity (FC), three pivotal

hubs of the indirect pathway, in 30 MDD patients with PMR

(PMR group) and well matched 30 patients without PMR (NPMR

group) at baseline, and 11 patients of each group at follow-up who

remitted after antidepressant treatment.


The results showed increased STN-striatum FC of PMR

group at baseline and no more discrepancy at follow-up, and signi-

ficant correlation between PMR severity and thalamo-STN FC.


Our findings suggested the increased STN- striatum

FC should be considered as a state biomarker to distinguish MDD

patients with PMR from patients without PMR at acute period, and

thalamo-STN FC could be identified as the predictor of the PMR

severity for MDD patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

e-Poster Walk: Ethics and psychiatry/Philosophy

and psychiatry/Others–Part 1


Is an isolation room harmful to

patients with schizophrenia?:

A biochemical study of salivary


A. Koreki

, M. Kiyohara , T. Koizumi , M. Onaya

National hospital oganizetion simofusa psychiatric center,

psychiatry, Chiba, Japan

Corresponding author.


Some patients with acute phase schizophrenia are

too agitated to receive treatment in a normal hospital room. They

must be isolated for the treatment. Although the stay in an isola-

tion room seems harmful to patients, no study detailing the stress

response to isolation with objective measures has been conducted.


Nine patients with schizophrenia or schizoaffective

disorder were recruited (mean age = 52 years, male = 3, schizophre-

nic = 7). At the time of evaluation, they were staying in an isolation

room. To evaluate stress response to the environment, the level of

salivary amylase was tested when the patients were either in the

isolation room (T1) or out of the isolation room (T2). T2 was defi-

ned as one hour after the room’s door was opened. The data were

analyzed by the Wilcoxon rank-sum test.


There is a significant difference between the median

(range) levels of salivary amylase at T1 and T2 (19 [2–146] vs 44

[9–178], respectively,


= 0.021).


The data demonstrate that the stress response at T2

was stronger than that at T1, which suggests that the isolation room

environment is less stressful to the patient compared to being out-

side the room. An environment that has many potential stimuli,

such as the presence of other patients and a television in the lobby,

may be harmful to patients with acute phase schizophrenia. The-

refore, although the isolation room is apparently harmful, it could,

in fact, have a positive effect on patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Outcomes of involuntary hospital

admission. Satisfaction with

treatment and the effect of

involuntary admissions on patients

T. Reshetukha

, N. Alavi , E. Prost , D. Groll , R. Cardy , N. Mofidi ,

P. Wang , C. Patel , S. Sajid

Queen’s university, department of psychiatry, Kingston, Canada

Corresponding author.


Involuntary hospitalization in those presumed to be

mentally ill has been a common practice. Although some patients

are hospitalized for aggression, two-thirds of the patients are hos-

pitalized because of the threat they pose to themselves. Although

these patients require risk assessment and evaluation for possible

presence of mental illness, the question is howmuch these patients

will benefit from involuntary admission and what the long-term

outcome would be.


All patients admitted involuntary to the psychiatricward

in Kingston, Canada, and psychiatrists involved in their care were

interviewed to see whether they think the involuntary admission

was helpful. All patients were asked to fill-out MacArthur AES to

assess their satisfaction with hospitalization.


Although psychiatrists frequently reported that the

admission was justified, only 29 out of 81 patients reported being