European Psychiatry - Volume 41 - April 2017

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S384 25th European congress of psychiatry / European Psychiatry 41S (2017) S365–S404
option. Many caregivers (46%) reported dissatisfaction with their
level of involvement in treatment decisions.
Conclusions This survey underlines the critical role HCPs play
in providing relevant information on treatment alternatives and
emphasize the need for an open dialogue on available treatment
options between HCPs, patients and caregivers.
Disclosure of interest Pierre Cherubin is a full-time Janssen
employee working within the Medical Affairs Department.
The other authors have not supplied their declaration of competing
interest.
EW0806
Lack of insight as a third variable
between subjective appraisal of
cognitive impairment and psychotic
symptoms
R. Rossi ∗, V. Santarelli , C. Marucci , D. Gianfelice , F. Pacitti
1 University of L’Aquila, Department of Applied Clinical Sciences and
Biotechnologies DISCAB, L’Aquila, Italy
2 S. Salvatore Hospital, Community Mental Health Department,
L’Aquila, Italy
∗ Corresponding author.
Background The relationship between subjective appraisal of
cognitive deficits and symptomseverity in schizophrenia is unclear.
Insight reportedly impacts on both factors. Our aim is to further
asses the relationship between the subjective perception of cog-
nitive deficits, symptom severity and lack of Insight as a mediator
variable.
Methods A total of 109 subject diagnosed with schizophrenia.
Positive and Negative Syndrome Scale (PANSS) was modelled as
dependent variable; Subjective Scale to Investigate Cognition in
Schizophrenia (SSTICS) was modeled as independent variable and
“Lack of Insight” (LoI) PANSS Itemwas tested as amediator variable.
Mediation was assessed using the Sobel Mediation Test.
Results LoI acts as a suppressor variable (i.e. it enhances the rela-
tion between the independent and dependent variable) between
SSTICS and negative symptoms, while showing a mediator effect
between SSTICS and depressive symptoms.
Discussion LoI has a central role in mediating the relationship
between subjective appraisal of cognitive deficits on the one hand
and positive and depressed symptoms on the other. Its suppres-
sor role between SSTICS and depression is consistent with several
reports of an enhanced risk of depression in patients fully aware
of their disability. Its mediator role between STICSS and positive
symptoms supports the centrality of LoI as ametacognitive function
whose failure may worsen psychotic symptoms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0807
Somatic comorbidities are associated
with poorer treatment outcome in
schizophrenia spectrum disorders,
independently of psychiatric
comorbidities and other clinical
factors
I. Simunovic Filipcic ∗, F. Igor , B. Marijana , K. Matic , I. Ena ,
V. Antonija , L. Nikolina , D. Rudan , B. Zarko
1 University Hospital Centre Zagreb, Department of Psychological
Medicine, Zagreb, Croatia
2 Psychiatric hospital “Sveti Ivan”, Department for Integrative
Psychiatry, Zagreb, Croatia
3 University Hospital Centre Zagreb, Department of Psychiatry,
Zagreb, Croatia
4 Biometrika Healthcare Research, Zagreb, Croatia
∗ Corresponding author.
Introduction Increased somatic morbidities in schizophrenic
patients and their association with HRQoL are well documented.
Less is known about their associationwith schizophrenia treatment
outcome.
Objective To explore whether the number of somatic comor-
bidities is associated with poorer psychosis treatment outcome
independently of psychiatric comorbidities and other clinical and
socio-demographic parameters.
Aim To improve understanding of association of somatic mor-
bidities on treatment outcome of schizophrenic patients.
Methods This nested-cross-sectional study was done during
2016 at Psychiatric hospital Sveti Ivan, Zagreb-Croatia on the
sample of 301 patients diagnosedwith schizophrenia spectrumdis-
order. Outcomes were the number of psychiatric rehospitalizations
since primary psychiatric diagnosis and the composite of signifi-
cant improvementmeasured by CGI-S and the best self-ratedhealth
defined as 4th quartile of EQ-5D-5L VAS. Predictors were number
of somatic and psychiatric comorbidities. By logistic regression, we
controlled socio-demographic and clinical confounders.
Results Having two or more somatic comorbidities was signif-
icantly associated with the failure to achieve the composite of
improvement. The number of somatic comorbidities was signifi-
cantly associatedwith increase in psychiatric hospitalizations, even
after the adjustment for psychiatric comorbidities and large num-
ber of clinical and socio-demographic variables.
Conclusions Chronic somatic comorbidities are associated with
poorer psychosis treatment outcome independently of psychiatric
comorbidities and other factors. Therefore, to treat psychosis effec-
tively it may be essential to treat chronic somatic comorbidities
promptly and adequately. The integrative approach should be the
imperative in clinical practice.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0808
Predictors of insight in patients with
schizophrenia
R. Softic ∗, A. Sutovic , E. Osmanovic , E. Becirovic ,
E. Avdibegovic , M. Mirkovic Hajdukov
1 University Clinical Center Tuzla, Psychiatry Clinic, Tuzla, Bosnia and
Herzegovina
2 BH Heart Center Tuzla, Cardiovascular Unit, Tuzla, Bosnia and
Herzegovina
∗ Corresponding author.
Aim To establish predictors of insight in patients with
schizophrenia with regard to symptoms severity, executive func-
tioning, level of education, marital status, age, and number of
hospitalizations.
Subjects and methods A cross-sectional study was conducted on
60 consecutive outpatients with schizophrenia. Positive symptoms
were established with 4-item Positive Symptom Ranking Scale
(PSRS), and negative symptoms with Brief Negative Symptoms
Assessment (BNSA). The level of insight was established with Self-
Appraisal of Illness Questionnaire (SAIQ). Executive functions were
established with Wisconsin card sorting test, and three verbal sub-
tests from Wechler’s Intelligence Test: information, similarities,
and calculating. All neuropsychological tests were administered by
psychologist educated in administration of these and other neu-
ropsychological tools.
Results Predictive statistical model identifies age and illness
duration as negative, and higher level of education, and being
married as a positive predictors of insight with 38.5% variance