European Psychiatry - Volume 41 - April 2017

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25th European congress of psychiatry / European Psychiatry 41S (2017) S365–S404 S389
29 patients. Those with the common deletion were typified by a
history of relapsing schizophrenia-like psychoses and partial non-
response to conventional antipsychotics. Inmost patients, anxieties
and mood instability were also manifest. The two patients with
a distal deletion predominantly showed anxiety symptoms, while
the behaviour of the patient with a central deletion was character-
ized by symptoms from the autism spectrum. Most patients with
a common deletion could successfully be treated with clozapine or
quetiapine, often combined with valproic acid. One patient with a
distal deletion showed full remission upon treatment with citalo-
pram (the second refused such a pharmacological intervention).
The behaviour of the patient with central deletion improved upon
contextual measures only.
Conclusions The genetic subtype of 22q11DS enables targeting of
treatment strategy.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0820
Clustering and switching on verbal
and nonverbal fluency in patients
with schizophrenia
M. Víchová ∗, T. Urbánek
1 Psychiatric Clinic, University Hospital in Brno, Department of
Psychology, Faculty of Arts, Masaryk University, Brno, Czech Republic
2 Faculty of Arts, Masaryk University, Department of Psychology,
Brno, Czech Republic
∗ Corresponding author.
In our study, we focus on the extent of occurrence of switching and
clustering during fluency task among patients with schizophrenia
compared to healthy controls. The previous studies found that both
switching and clusteringwere affected in patientswith schizophre-
nia. However, it has not clear yet if the decrease is caused by the
impairment of executive functions or is related to poorer vocab-
ulary. In our study, participants were tested Verbal Fluency Task
(phonological and semantic) and also the nonverbal fluency task
(measured by Five Point Test) so that the effect of vocabularywould
be removed. Our study included 50 participants: 25 individuals
with schizophrenia and 25 healthy controls. We found significant
differences in the way of organization between group of psychi-
atric patients and healthy controls. The absence of clustering is
typical for psychiatric population, patients tell the words without
closer connection, they neglect association links, switch between
clusters. Due to this way of response, they achieved lower score,
they told fewer words than healthy controls. However, this manner
was found also in nonverbal task where the patients did not follow
one-way in drawing patterns and they often change the number of
connecting dots or used lines. Our study implies that this condition
is probably caused by disruption of the executive functions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0821
Memory and medial temporal lobe
structures in patients with
schizophrenia and their siblings
V. Vorackova (Postgraduate student) ∗, P. Mohr ,
P. Knytl (Postgraduate student) , I. Fajnerova , A. Dorazilova ,
Z. Kratochvilova , A. Skoch , M. Rodriguez
1 National Institute of Mental Health, Applied Neurosciences and
Brain Imaging, Klecany, Czech Republic
2 Third Faculty of Medicine, Charles University, Prague, Czech
Republic
3 National Institute of Mental Health, Diagnostics and Treatment of
Mental Disorders, Klecany, Czech Republic
4 Third Faculty of Medicine, Charles University, Department of
Psychiatry and Medical Psychology, Prague, Czech Republic
5 Institute for Clinical and Experimental Medicine, Department of
Clinical and Experimental Spectroscopy, Prague, Czech Republic
∗ Corresponding author.
Episodic retrieval is characterized by the subjective experience of
remembering. Semantic memory, on the other hand, is a more
structured record of facts, meanings, concepts and knowledge
about the external world that we have acquired. Themedial tempo-
ral lobe (MTL), especially the hippocampus and parahippocampal
cortex, plays a central role in both types of memory process. Pub-
lished studies suggested that individuals with schizophrenia have
deficits in episodic and semantic memory, as well as structural
abnormalities of the medial temporal lobe. However, it is not clear
whether reported correlations reflect the impact of the disease state
or that of underlying genetic influences contributing to the risk. To
understand better etiology and effects of psychosis on the global
brain structure and cognitive processing, relatives of individuals
with schizophrenia can be studied. The aim of our study was to
examine the association between abnormalities of the MTL, psy-
chopathology, and memory impairment in schizophrenia. Study
sample (n = 60) consisted of first episode schizophrenia patients,
their non-psychotic siblings and matching control subjects. We
used high-resolution magnetic resonance imaging and probabilis-
tic algorithms for image analysis. Episodic and semantic memory
was measured with neuropsychological tests. Our results showed
differences in memory performance between the groups. Neu-
ropsychological datawere correlatedwithMRI findings. The results
may provide insight into etiology of schizophrenia and its effects
on cognition and help to identify neuroanatomical and cognitive
endophenotypes of psychotic disorders.
Supported by the grant projects MH CR AZV 15-28998A, MEYS
NPU4NUDZ: LO1611; Czech Science Foundation, grant No. 16-
13093S; Institutional Support 00023001IKEM.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0822
Hope, self-stigma, personality traits
and quality of life in patients with
psychotic disorders
K. Vrbova ∗, J. Prasko , K. Latalova , D. Kamaradova ,
M. Ociskova , M. Marackova , M. Holubova , M. Slepecky
1 Faculty of Medicine and Dentistry, Palacky University and
University Hospital Olomouc, Department of Psychiatry, Olomouc,
Czech Republic
2 Faculty of Medicine and Dentistry, Palacky University and
University Hospital Olomouc, Hospital Liberec, Department of
Psychiatry, Olomouc, Liberec, Czech Republic
3 Faculty of Social Science and Health Care, Constantine the
Philosopher University in Nitra, Department of Psychology Sciences,
Nitra, Slovak Republic
∗ Corresponding author.
Introduction Recently, as a result of an increased emphasis on
patients’ needs, the awareness on the quality of life has been
engaged into account in the exploration of schizophrenia.
Objectives The aim of the study was to explore the relations
between hope, self-stigma, personality traits and quality of life in
patients with schizophrenia spectrum disorder.
Methods Fifty-two stabilized outpatients with schizophrenia
spectrum disorders participated in cross-sectional study. The
psychiatrist assessed each patient with Mini International Neu-
ropsychiatric Interview and Clinical Global Impression-Severity.
The patients completed Quality of Life Satisfaction and Enjoy-