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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S405–S464 S463
A 28-year-old patient who began three months of symptoms of low
mood, apathy and anhedonia. The patient in this last month had
accepted a job but the first day had left by “feeling incapable”. He
asked for specialized help. He was diagnosed with severe depres-
sive episode and antidepressant treatment. Some weeks of patient
treatment did not improve. He began to voice greater feelings of
hopelessness and ideas of active death secondary to his process. He
was admitted a partial hospitalization for further control and eval-
uation. In his evolution, visual hallucinations and a mild delusional
ideation of unstructured surveillance and injury were observed.
The patient verbalized with little repercussion these sensopercep-
tive alterations. Neuroleptic treatment was given but we could not
manage high doses because of poor tolerance and side effects of
treatment. The symptomatology did not improve and the patient’s
anguish increased. In the moments of greater distress, the patient
performed superficial cuts on his forearms that he criticized. Dur-
ing the following months, symptoms of an obsessive type were
observed, which had already pre-entered but had been reactivated.
He began to perform rituals of verification with important reper-
cussion.
Discussion In the scientific literature the relationship between
psychosis and obsession has been studied onmany occasions, with-
out reaching firm conclusions. In 2004, Poyurosvsky postulated
the possible diagnosis of a subgroup called “schizo-obsessive” that
included both disorders.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0186
Safety and efficacy of sildenafil citrate
in treating erectile dysfunction in
patients with combat-related
post-traumatic stress disorder: A
double-blind, randomized and
placebo-controlled study
M.R. Safarinejad
Clinical Center for Urological Disease Diagnosis and Private Clinic
Specialized in Urological and Andrological Genetics, Urology, P.O. Box
19395-1849, Tehran, Iran
To evaluate the safety and efficacy of sildenafil citrate for treating
erectile dysfunction (ED) in patients with combat related post-
traumatic stress disorder (PTSD).
Patients and methods In all, 266 combat-exposed war veterans
with ED (aged 37–59 years) were recruited. They met the Diag-
nostic and Statistical Manual of Mental Disorders-IV criteria for
PTSD according to the Structured Clinical Interview for Patients,
Investigator Version. The patients were also evaluated with the
Clinician-Administered PTSD Scale, both to establish the diagno-
sis of PTSD and to measure symptom severity. Only patients with
psychogenic ED were included in the study. The patients were
randomly divided into a group of 133 who received 100mg of on-
demand sildenafil 0.75–2 h before sexual stimulation, and 133 who
received placebo. Patients were asked to use ≥ 16 doses or attempts
at home.
Results Sildenafil did not produce significantly and substan-
tially greater improvement than placebo in each of the primary
and secondary outcome measures (P = 0.08). A normal EF domain
score (≥ 26) at endpoint was reported by 13 (9.8%), and 11 (8.3%)
of patients on the sildenafil and placebo regimens, respectively
(P = 0.09). Patients treated with sildenafil had no statistically sig-
nificantly greater improvement in the five sexual function domains
of the IIEF questionnaire than those treated with placebo (P = 0.08).
The incidences of treatment-emergent adverse events were sig-
nificantly greater in the sildenafil arm than in the placebo group
(P = 0.01).
Conclusions Sildenafil is no better than placebo in treating PTSD-
emergent ED.
Disclosure of interest The author has not supplied his declaration
of competing interest.
EV0187
Resilience and risk, metal health and
well-being: How do these concepts
relate?
F. Schultze-Lutter ∗ chsenbein , S.J. Schmidt
University of Bern, University Hospital of Child and Adolescent
Psychiatry and Psychotherapy, Bern 60, Switzerland
∗ Corresponding author.
Introduction Resilience and well-being have become common-
place and increasingly used terms in a wide range of scientific as
well as mental health political contexts.
Objectives There is much confusion about the relationship of the
two constructs: while some use well-being as a proxy measure of
resilience, others treat one concept as a component of the other or
see interchangeably one as the prerequisite of the other.
Aims To study the definition of these two concepts in relation to
each other.
Methods Literature review.
Results Both ‘resilience’ as well as ‘well-being’, have so far defied
universal definition and common understanding of their respec-
tivemeasurement. Part of the confusion around these two concepts
is the overlap in their components, in particular with regard to
resilience and psychological well-being, and the lack of research on
these concepts both by themselves, in relation to each other and in
relation to other concepts like mental health, risk or protective (or
promotive) factors.
Conclusion Our critical and comparative inspection of both con-
cepts highlights the need for more conceptual cross-sectional as
well as longitudinal studies:
– to uncover the composition of these constructs and to reach
agreement on their definition and measurement;
– to detect their potential neurobiological underpinnings;
– to reveal how they relate to each other;
– to determine the potential role of developmental and cultural
peculiarities.
Thus, the use of the terms resilience and well-being should always
be accompanied by a brief explanation of their respectivemeanings
and theoretical framework.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0188
Translational inhibitors as potential
therapeutic tool of human
neuroblastoma through
mitochondrial gene expression
S. Hina
International Center for Chemical and Biological Sciences, University
of Karach, Dr. Panjwani Centre for Molecular Medicine and Drug
Research, Karachi, Pakistan
Neuroblastoma is a solid neuroendocrine tumour and most com-
mon type of cancer of infancy. It is a complex heterogeneous disease
and many factors such as molecular, cellular and genetic features
are involved in its development. Mitochondria play a pivotal role in
neuronal cell survival or death. Neurons are highly reliant on aer-
obic oxidative phosphorylation (OXPHOS) for their energy needs.
Defective activities of mitochondrial complexes I, II, III and IV
have been identified in many neurological and neurodegenerative