European Psychiatry - Volume 41 - April 2017

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S558 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S521–S582
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0472
The impact of self-esteem on eating
disorders
F. Mora ∗ ernandez Rojo , C. Banzo , J. Quintero
Hospital Universitario Infanta Leonor, Psychiatry, Madrid, Spain
∗ Corresponding author.
Introduction Eating disorder (ED) are an important mental health
problem because of theirs overall prevalence, especially in children
and adolescents. Low self-esteem is considered, along with oth-
ers, one of the risk factors for the development of these disorders,
without having clarified the real impact of low self-esteem on the
development of ED. The aim of this study is to analyze the rela-
tionship between self-esteem and the risk of developing an eating
disorder.
Material and method We have selected a sample of 500 patients
who were in the 2nd year of secondary school to which has been
applied a battery of scales including the Rosenberg self-esteem
scale, and the EAT-26 scale for ED. We used logistic regression using
SPSS to analyze the relationship between both variables.
Results In addition to analyzing clinical and sociodemographic
characteristics of the sample, we have found that for every decrease
of 1 point in Rosenberg scale, there is an increase of 9 % in the
probability of being a case of ED for the EAT-26 scale (P< 0.05).
Conclusions Regarding these results, we can conclude that, in our
sample, having low self-esteem score, significantly increases the
likelihood of having a high score on the scale of ED. This data can
be useful in establishing a preventive strategy and an adequate
treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0473
Cortisol awakening response in
binge-purging and restrictive
anorexia nervosa
M. Nigro ∗, A.M. Monteleone , F. Pellegrino , M. Cimino ,
V. Di Maso , U. Volpe , P. Monteleone
1 Second University of Naples, Psychiatry, Naples, Italy
2 University of Salerno, Medicine, Surgery and Dentistry “Scuola
Medica Salernitana”, Section of Neuroscience, Salerno, Italy
∗ Corresponding author.
Introduction Anorexia nervosa (AN) is a complex psychiatric
disorder characterized by severe restriction of food intake and aber-
rant behaviours. The endogenous stress response system, including
the hypothalamus-pituitary-adrenal (HPA) axis, may have a role in
the pathophysiology of AN.
Objectives It has been shown that specific clinical traits of AN,
such as binge-purging behaviours, may be associated with higher
psychopathology and poorer outcomes. Therefore, the HPA axis
functioning could differ between patientswith restrictive AN (ANR)
and those with binge-purging AN (ANBP).
Aims In order to evaluate whether HPA axis functioning differs
between the two subtypes of AN, we assessed the cortisol awaken-
ing response (CAR) of symptomatic ANR and ANBP patients.
Methods Our sample included 17 ANBP and 18 ANR patients,
and 42 healthy women. All of them filled in the Eating Disorder
Inventory-2 (EDI-2). For CAR assessment, participants collected
saliva samples at home. Saliva cortisol concentrations were mea-
sured by an enzyme immunoassay method.
Results ANR and ANBP patients exhibited a CAR significantly
higher than healthy women. Furthermore, the CAR of ANBP women
was higher than that of ANR women and positively correlated with
the bulimia subitem score of the EDI-2.
Conclusions Present findings show, for the first time, differences
in the CAR between ANBP and ANR subtypes supporting the idea
that binge-purging behaviours may have a specific connectionwith
HPA axis.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0474
Association between eating disorders
and 5-HTTLPR polymorphism:
The experience of an Italian eating
disorders unit
M.G. Oriani ∗, M. Barchiesi , L. Sabbatini , B. Nardi
1 Centro Salute Mentale Ancona AV2 ASUR MARCHE, Department of
Mental Health, Ancona, Italy
2 Clinica Psichiatrica, Az. Ospedaliero-Universitaria Ospedali Riuniti,
Ancona, Italy
∗ Corresponding author.
Introduction Eating Disorders (ED) as Anorexia Nervosa (AN),
Bulimia Nervosa (BN) and Binge Eating Disorder (BED) are severe
and debilitating psychiatric diseases whose etiology is complex and
still largely unknown. Several studies seem to suggest that sero-
tonin could be involved and notably there are several associations
with 5-HTTLPR polymorphism, especially with the S allele and the
S/S genotype.
Objectives The purpose of this study is to evaluate if an associa-
tion between ED and 5-HTTLPR (especially the S allele frequency)
can be shown.
Material and methods A group of about 100 subjects attending
the eating disorders unit of Ancona will be tested. Their DNA will
be taken and the frequency of the S allele will be compared with a
control subjects group negative for ED. Then, the ED group will be
divided, according to the DSM-5 criteria, in 3 subgroups (AN, BN,
BED) and potential differences will be evaluated.
Results At the moment, we are still collecting patients. According
to other studies involving 5-HTTLPR, the S allele frequency in Italy
is comparable with the European one, so there is reason to believe
that an association could be found.
Conclusions Serotonin involvement in ED in literature is shown,
but it still has to be completely expounded. Studies as this one could
help in describing the etiology and the development of this disease.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0475
Visuo-Haptic information processing
in patients suffering of anorexia
nervosa
G. Riss ∗ . Martoni . Cavallini rzegovesi
G. Baud-Bovy
1 IRCCS San Raffaele, Milano, Department of Clinical Neurosciences,
Eating Disorders Unit, Milano, Italy
2 IRCCS San Raffaele, Milano, Department of Clinical Neurosciences,
Obsessive Compulsive Spectrum Disorders Unit, Milano, Italy
3 Istituto Italiano di Tecnologia, Genoa, Italy, Robotics, Brain and
Cognitive Sciences Unit, Genoa, Italy
4 IRCCS San Raffaele Scientific Institute, Milan, Italy, Unit of
Experimental Psychology, Neuroscience Division, Milano, Italy