European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S583–S644 S633
ficulties in ambulation, increment of falls, and lack of hygiene
and dietary transgression. Complementary explorations blood
test: hemogram and biochemical unaltered, hypertriglyceridemia,
syphilis, HIV serology negative. Diagnosis stable PSP, behavioral
disorders are objectified within his personality disorder. Pharma-
cological approach. In case levodopa causes clinical symptoms of
postural hypotension, stalevo is decreased and sinemet is removed.
Slight improvement is noticed. Case review PSP is an uncommon
brain disorder that affects movement, control of walking and bal-
ance, vision, cognitive impairment and neuropsychiatric disorders.
It is associated with the deposition of hyperphosphorylated, tau,
in the pallidum, subthalamic nucleus, red nucleus, etc. Cognitive
deficits and neuropsychiatric symptoms may precede the onset
of Parkinsonism. Most changes are referred to personality, with
presence of irritability, impulsivity. Psychotic symptoms may exist.
There are no disease-modifying treatments. Management should
focus on optimizing life quality.
Disclosure of interest The author has not supplied his declaration
of competing interest.
EV0705
Psychosis and Schizencephaly – A case
report and systematic review
S. Gunturu , L. Schmalz , J. Zebelian , L. Gonzalez ,
C. Drazinic ∗, P. Korenis
1 University of Miami – Miller School of Medicine, Psychiatry, Miami,
USA
2 Bronx Lebanon Hospital Center, Psychiatry, NY, USA
3 University of Miami – Miller School of Medicine, Psychiatry, Miami
Beach, USA
∗ Corresponding author.
Psychotic symptoms have been reported in association with a
wide array of brain abnormalities. Few published reports have
examined the association between schizencephaly and psychi-
atric illness. Originally defined by Wilmarth and later by Yakolev
and Wadsworth – Schizencephaly is an uncommon congenital
disorder of cerebral cortical development, defined as a greymatter-
lined cleft extending from the pial surface to the ventricle. The
nosology is based on neuroradiologic findings and confirmed by
neuropathology when available. The Clinical presentation and neu-
rodevelopmental outcomes of the disorder vary and are usually
related to the extent/areas of the brain involved. In this article we
review the medical literature around Schizencephaly paying par-
ticular attention to the pathophysiology, etiology and diagnosis of
such patients. We then present a case of Schizencephaly and first
episode psychosis in a 16-year-old adolescent who was admitted
to our inpatient psychiatric service. Lastly, we present the findings
of a systematic review from PubMed whereby we summarize 10
cases of Schizencephaly with associated psychiatric symptoms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0706
Glutamatergic synaptic plasticity in
the periaqueductal gray governs
fear-induced depression-like behavior
in rats
Y.C. Ho ∗, M.C. Hsieh , C.Y. Lai , H.Y. Peng
Mackay Medical College, Department of Medicine, New Taipei City,
Taiwan, ROC
∗ Corresponding author.
Introduction Major depressive disorder affecting more than 110
million people worldwide every year is a heterogeneous illness
influenced by a variety of factors, including repeated stressful
factors. Despite widely research during the past several decades,
the pathophysiology and neurobiological mechanisms of depres-
sive disorders remain unclear. Ventrolateral periaqueductal gray
(vlPAG), a midbrain nucleus, has been considered as an important
part of the circuitry that involves in stress-induced depression-
like behaviors. Dysregulation of glutamatergic neurotransmission
in depressed patients suggests that glutamate-mediated excitatory
system is critical involved in the depressive disorders.
Objectives It is still unclear that whether vlPAG involves in fear
condition-elicited depression-like behavior.
Aims We investigated the synaptic transmission in the vlPAG to
examine whether vlPAG participates in fear-induced depression-
like behavior in rats.
Methods Depression-like behaviors, in the rats, were induced
by learned helplessness procedure. The synaptic transmission was
conducted by whole-cell patch-clamp recording in the rat brain
slices containing periaqueductal gray.
Results Rats receiving learned helplessness procedure displayed
high failure rate in the escapable foot-shock test compared to con-
trol group. Both amplitude and frequency of miniature excitatory
postsynaptic currents were significant reduced compared to con-
trol group, suggesting reduced presynaptic glutamate release and
postsynaptic responses were involved in the learned helplessness
procedure-induced depression behavior in rats.
Conclusions Reduced glutamatergic transmission in the
vlPAG contributes to learned helplessness procedure-induced
depression-like behavior in rats through pre – and post-synaptic
mechanisms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0707
Inter-analyzer interaction (IAI) at
clinical psychology: Possibilities and
challenges
M. Kovyazina ∗ omina
1 Lomonosov Moscow State University, Department of
Psychology – Chair of neuro – and abnormal psychology, Moscow
original-Mytishchi, Russia
2 Lomonosov Moscow State University, Department of
Psychology – Chair of neuro – and abnormal psychology, Moscow,
Russia
∗ Corresponding author.
Introduction White matter is an anatomical bases of brain inte-
gration realization, it provides the connection between different
cortex zones inside one hemisphere as well as other hemisphere.
Hemispheric interaction research is basic aspect of brain integra-
tion activity problem. Not less important is the aspect related with
the processes of IAI.
Aims Evaluation of method by fixed set potential for neuropsy-
chological research of inter-analyzer interaction.
Methods Russian neurophysiologists confirmed the presents of
nervous processes irradiation and considered it as fundamental
mechanisms of the higher functions realization. IAI is a particular
case of the irradiation.
Uznadze’s fixed set method allows one to model “section of behav-
ior”, which includes all general behavior mechanisms and provides
a way to analyze complicated forms of activity. The central compo-
nents of the set are related to different brain systems and analyzer’s
interactions. This is confirmed by the set irradiation experiments,
performed by Uznadze’s school and showed that the set forms in
one sensory modality manifests in different.
Results Setting experiments by formation of fixed set are done
at haptic sphere: two different in volume spheres are given into
both respondents’ palms. Critical experiments are done at visual