European Psychiatry - Volume 41 - April 2017

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S638 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S583–S644
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0719
Case report Klinefelter syndrome and
multiple sclerosis as the cause of
psychosis
A. Rodriguez Rodriguez ∗ lanco Fernández ,
M. Vizcaino da Silva , R. Fernández Fernández ,
O. Mendez Gonzalez
Universitary Hospital Puerta de Hierro, Brief Hospitalization Unit
Psychiatry, Majadahonda, Spain
∗ Corresponding author.
Introduction and goals Forty-three-year-oldmale diagnosedwith
Klinefelter syndrome and showing radiological findings suggest-
ing a demyelinating pathology who presents several psychiatric
manifestations including megalomaniacal ideation, delusion, lack
of impulse control and behavioral alterations.
Clinical case Forty-three-year-old male diagnosed with Kline-
felter syndrome at the age of 31, presenting several psychiatric
pathologies since adolescence: delusions, megalomania, mood
fluctuation, and high impulsiveness. The patient had a poor
therapeutic response to anti-psychotic drugs and ECT. He was hos-
pitalized up to 9 times, but the full control of the symptomatology
was not achieved. During his last hospitalization, a MRI revealed
lesions compatible with a demyelinating pathology.
Discussion A higher prevalence of schizophrenia spectrum disor-
ders has been described among patients suffering from Klinefelter
syndrome, which might explain the role of the X chromosome
in the susceptibility to psychiatric disorders, particularly to psy-
chosis. Furthermore, the brain structure alterations presented by
patients suffering from Klinefelter syndrome are similar to those
described among schizophrenic patients: small brain volume, lat-
eral cerebral ventricular enlargement and reduced temporal gyrus,
amygdala, insula and cingulate cortex. Patients suffering frommul-
tiple sclerosis aremore prone to psychiatric disorders, such asmood
swing, aggressiveness or psychosis, which are not concurrent with
the physical progression of the disease, sometimes being its first
manifestation. Even when being patchy and multifocal, demyeli-
nation seems to be concentrated in the frontal lobes, related to the
cognitive and affective functions and the personality.
Conclusions Both multiple sclerosis and Klinefelder syndrome
may alter the brain structure, mainly in the frontal lobe, and pre-
dispose to psychiatric disorders.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0720
Neuroretinal dysfunctions in regular
cannabis users: An impact of cannabis
on retinal neurotransmission?
T. Schwitzer ∗ chwan Giersch lbuisson
K. Angioi-Duprez aprevote
1 Centre psychothérapique de Nancy, Pôle hospitalo-universitaire de
psychiatrie du Grand Nancy, Laxou, France
2 Inserm U1114 Fédération de Médecine Translationnelle de
Strasbourg CHRU de Strasbourg, Département de Psychiatrie,
Strasbourg, France
3 CHRU de Nancy, Pôle S2R – Parc – Espri-biobase,
Vandoeuvre-lès-Nancy, France
4 CHRU de Nancy, Département d’Ophtalmologie,
Vandoeuvre-lès-Nancy, France
∗ Corresponding author.
Introduction Although cannabis is very widespread worldwide,
its brain toxicity is poorly understood. The neuroretina is an
accessible extension of the brain and could be a relevant site for
investigating neurotransmission abnormalities in neuropsychiatric
disorders. The retina has a functional endocannabinoid system
involved in the regulation of retinal neurotransmission. In animals,
the modulation of this system led to retinal dysfunctions measured
with the electroretinogram (ERG).
Objectives To assess whether the regular cannabis use could
affect the neuroretinal function.
Aims Assessments of the neuroretinal function in cannabis users
compared with controls.
Methods Recordings of pattern, flash and on-off ERG were per-
formed in 55 cannabis users and 29 controls. The amplitude and
implicit time of the followingwaveswere evaluated: N95 (pattern);
a – and b – (flash); a –, b- and d1 – (on-off).
Results Cannabis users showed a significant increase in implicit
time of the waves N95 (P = 0.0001), a- (P = 0.029) and b – (P = 0.002)
for the flash ERG and b – ( P = 0.016) and d1 – (P = 0.027) for the
on-off ERG, compared with controls. No significant difference was
found between groups in terms of wave’s amplitudes.
Conclusions These results show a delay in the response of cones,
bipolar and ganglion cells of the on and off pathways to constitute a
delay of ≈6ms in the transmission of information fromthe retina to
the brain in cannabis users. Cannabis could disrupt the regulatory
role of the cannabinoid system and impair retinal glutamatergic
neurotransmission. The consequences on visual perception should
be explored in future studies.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0721
In search of possible peripheral
biomarkers for suicide: Similarities
between platelet and cerebrospinal
fluid proteome (preliminary results)
E. Semanˇcíková ∗ káˇciková alian Bencková
E. Pálová , J. Sabo
1 University of P. J. ˇSafárik, Department of Medical and Clinical
Biophysics, Koˇsice, Slovak Republic
2 EPAMED s.r.o, Koˇsice, Slovak Republic
∗ Corresponding author.
Despite the fact that proteomic analysis is becoming widely used in
various medical branches its use in psychiatry is still very limited.
Majority of psychiatric proteomic research is still oriented mostly
on Alzheimer’s disease, schizophrenia and depression but very few
studies focus on suicidality. We decided, based on the current
knowledge, to study suicidal behaviour with the use of proteomics
to compare cerebrospinal fluid and platelets. We hypothesized that
the same protein group can be detected in pathways that are part of
platelet degranulation process in the platelet proteome and cere-
brospinal fluid proteome. Based on these findings we suppose, that
with use of proteomic analysis a specific protein (group of proteins)
can be identified in both, cerebrospinal fluid and platelet proteome
in patients with suicidal behavior.
Group of proteins identified in our sample in the reactome path-
way database (release of platelet secretary granule components
and exocytosis of platelet granule contents) supports the idea of
link between central nervous system and platelets (“the periph-
ery”). Further research is needed to clarify whether the identified
group of proteins taking part in platelet pathways can be used as
peripheral biomarkers for suicidal behavior.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.