European Psychiatry - Volume 41 - April 2017

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S82 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105
Eighty-nine participants with 22q11DS (age range: 8–30 years;
mean: 16.1647) were assessed using the structured interview for
psychosis-risk syndromes. Information on axis I diagnoses, inter-
nalizing and externalizing symptoms, level of functioning and IQ
was also collected. At baseline, 22 (24.7%) participants met UHR
criteria. Compared to those without a UHR condition, they had a
significantly lower functioning, more frequent anxiety disorders
andmore severe psychopathology. Transition rate to psychosis was
27.3% in UHR and 4.5% in non-UHR participants. Cox regression
analyses revealed that UHR status significantly predicted conver-
sion to psychosis. Baseline level of functioning was the only other
additional predictor. This is the first study investigating the predic-
tive value of UHR criteria in 22q11DS. It indicates that the clinical
path leading to psychosis is broadly comparable to that observed in
other clinical high-risk samples. Nevertheless, the relatively high
transition rate in non-UHR individuals suggests that other risk
markers should be explored in this population. The role of low
functioning as a predictor of transition to psychosis should also
be investigated more in depth.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O037
Family environment as predictor of
adolescents’ loneliness
M. Baláˇzová ∗, I. Gallová , J. Praˇsko , M. ˇSlepeck ´y , A. Kotianová
University of Constantinus the Philosopher in Nitra, Department of
Psychological Sciences, Nitra, Slovak Republic
∗ Corresponding author.
Introduction At the present time, adolescents are in particular
vulnerable to feelings of loneliness. They are gradually emancipat-
ing from their family and establish relationships with peers. Among
the important predictors of loneliness belong genetic and personal
variables and factors of social environment.
Objectives and aims To examine predictors of adolescents’ lone-
liness which are located in family environment. To find out how
empathy, emotional relationship and control by both of parents
contribute to loneliness of adolescent boys and girls.
Methods We examined 206 adolescents in the age from 10 to 18
years through Basic Empathy Scale, Parenting Style Scale and UCLA
Loneliness Scale. Stepwise multiple linear regression analysis was
used for data analysis.
Results The significant predictors of boys’ loneliness in family
environment are emotional relationship of mother and affective
empathy of father. The significant predictors of girls’ loneliness
include emotional relationship and cognitive empathy of father.
Parental control is not a significant predictor of adolescents’ lone-
liness.
Conclusion Adolescents’ loneliness is largely influenced by fac-
tors of family environment. Our study highlights the role of
emotional relationship provided by the opposite sex parent. Cold
behavior of the opposite sex parent could reduce self-esteem and
self-confidence of adolescents. Both could help themestablish rela-
tionships with peers and people outside family, thus protecting
them against loneliness. A significant predictor of boys’ and girls’
loneliness is also empathy of father. We recommend to make use of
our findings in clinical practice with adolescents, in family therapy
as well as in context of attachment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O038
A case control and follow-up study of
“hard to reach” young people who
also suffered from multiple complex
mental disorders
N. Camilleri ∗, P. McArdle , D. Newbury-Birch , D. Stocken ,
A. LeCouteur
1 Mount Carmel Hospital, Department of Psychiatry, Attard, Malta
2 Newcastle University, Institute of Health and Society, Newcastle,
United Kingdom
3 Northumberland Tyne and Wear NHS Foundation Trust, Institute of
Health and Society, United Kingdom
4 Teeside University, Health and Social Care Institute,
Middlesborough, United Kingdom
5 Institute of Health and Society, Newcastle University, Newcastle,
United Kingdom
∗ Corresponding author.
Aims To describe the mental disorders and social function of the
hard to reach young people (HTRYP) from the innovations project
(IP) and compare to a matched sample from a community mental
health team (CMHT).
Background IPwas a newmultidisciplinary teambasedwithin an
inner city, walk-in health centre, North East England (throughout
2011).
Methods Phase 1 and 2: retrospective reviewof clinical case notes
of YPwho attended the IP and CMHT. Phase 3: 24-months follow-up
evaluation of the mental state and social function, using Health of
the Nation Outcome Scales for Child and Adolescent Mental Health
(HoNOSCA) and Children’s Global Assessment Scale (CGAS).
Results Overall, 36 referrals accepted by the IP, 31 met criteria
for HTRYP, 15 were offered individually tailored therapy. IP group
experienced more deprivation compared to the CMHT matched
sample (n = 115). At baseline, the HTRYP had more mental dis-
orders, higher severity scores and lower levels of social function
(HTRYP HoNOSCA mean: 19.1 and CMHT mean: 11.2 P = < 0.001
and HTRYP CGAS mean: 51.0, CMHT mean: 58.9, P= 0.05). The
HTRYP made significantly greater improvement compared to
CMHTYP; (HoNOSCA P = < 0.001 and CGAS P = < 0.002). Thirteen
HTRYP attended the follow-up review at 24months comparedwith
nine of CMHTYP. There was great variability in terms of social func-
tion between the YP within each sample.
Conclusion The term “HTR” describes a state, which the YP may
be at a particular point their lives. A service, which utilises a devel-
opmental theoretical framework, offers regular reviews and an
individualised care plan, could reduce longer-term morbidity and
mortality suffered by HTRYP.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O039
Implications of COMT and subclinical
psychiatric symptoms on the
phenotypic variability of 22q11.2
deletion syndrome: A transversal and
longitudinal approach
S. Guerrera ∗, M. Armando , M. Pontillo , F. Papaleo , S. Vicari
1 Child Psychiatry Unit- Bambino Gesù Children’s Hospital- IRCCS,
Department of Neuroscience, Roma, Italy
2 Istituto Italiano di Tecnologia, Department of Neuroscience and
Brain Technologies, Genova, Italy
∗ Corresponding author.
Introduction 22q11.2 deletion syndrome (22q11.2DS) results
from a hemizygous microdeletion on chromosome 22 and is char-
acterized by phenotypic variability. Several studies have been