European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105 S81
perform a confirmatory factor analyses (using Mplus software) to
verify if the three dimensions’ structure fitted the data.
Methods The sample comprised 234 students on their first three
years of college education (78.2% female), between 18–26 years old
(M= 20.55; SD = 1.66). Participants filled the Portuguese version of
the MOCI.
Results Our results showed that the MOCI Portuguese version
with original 3-factor structure has a good fit ( 2
(227) = 386.987,
P < .05; RMSEA = 0.053, 90%CI = 0.044–0.062; CFI = 0.928;
TLI = 0.920; WRMR = 1.089). Good reliability was found for all
subscales (Cronbach alpha < .80).
Conclusions The MOCI Portuguese version reliably and validly
assesses three OC symptom dimensions in young adults. Further
research is needed to confirm this structure in Portuguese clinical
samples.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O034
What antipsychotic is more effective?
Pafip three years longitudinal study
comparing haloperidol, risperidone,
olanzapine, quetiapine, ziprasidone
and aripiprazole
M. Gomez Revuelta ∗, P. Alonso Alvarez , J.L. Garcia Egea ,
M. Juncal Ruiz , O. Porta Olivares , L. Sanchez Blanco ,
D. Abejas Diez , G. Pardo de Santayana Jenaro ,
R. Landera Rodriguez
1 Hospital Universitario de Álava-Sede Santiago- Vitoria-Gasteiz-
Spain, Psychiatry, la Penilla, Spain
2 Hospital Universitario Marques de Valdecilla, Santander, Spain,
Psychiatry, Santander, Spain
3 Hospital Universitario Virgen Del Rocio, Psychiatry, Sevilla, Spain
4 Hospital Universitario Marques de Valdecilla, Psychiatry,
Santander, Spain
∗ Corresponding author.
Introduction Early stages after a first psychotic episode (FEP) are
crucial for the prognosis of the disease. Those patients who drop
out of treatment after a FEP show a significant increase in their
vulnerability to relapse. Relapses associated a greater risk of neu-
rotoxicity, chronicity, hospitalization, decrease of response to the
treatment, increase of burden and functional decline.
Objectives To determine what antipsychotic is more effective in
the prevention of relapse after a first psychotic episode.
Material and methods PAFIP is an assistance program focused on
early intervention in psychosis. Between January 2001 and January
2011, 255 patients were recruited and randomly assigned to treat-
ment with haloperidol (n = 48), olanzapine (n = 41), risperidone
(n = 44), quetiapine (n = 34), ziprasidone (n = 38) and aripiprazole
(n = 50). We compared the rates of relapse and remission reached
by haloperidol, olanzapine, risperidone, aripiprazole, ziprasidone
and quetiapine during a 3-year follow-up. All of the patients were
antipsychotic naives at the beginning of the treatment.
Results There were no statistically significant differences in
regard to the rate of clinical remission. Patients assigned to the
groups of aripiprazole, olanzapine and risperidone presented a
solid trend to a significantly inferior rate of discontinuation for any
reason since the beginning of the treatment.
Conclusions These data point to a greater protection against
relapse and a likely better prognosis related to the use of aripipra-
zole, Olanzapine and risperidone.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O035
Predictors of sleep difficulties in
college students
A. Paula Amaral ∗, M. João Soares , A.T. Pereira , M. Bajouco ,
B. Maia , M. Marques , J. Valente , A. Macedo
1 Faculty of Medicine, University of Coimbra, Psychological Medicine,
Coimbra, Portugal
2 Institute Polytechnic of Coimbra, ESTESC, Coimbra Health School,
Coimbra, Portugal
3 Faculty of Philosophy and Social Sciences - Catholic University of
Portugal, Braga Regional Centre, Braga, Portugal
∗ Corresponding author. Faculty of Medicine, University of Coimbra,
Psychological Medicine, Coimbra, Portugal.
Introduction College students are known for their variable sleep
schedules. Such schedules, along with other common student prac-
tices are associated with poor sleep hygiene. The persistence of the
precipitating stressor is one of the factors involved in the persis-
tence of insomnia.
Aims To examine the role of the perceived stress, perseverative
thinking, strategies of cognitive emotion regulation and negative
affect as predictors of sleep difficulties.
Methods The sample comprises 549 college students.
Measures PSS-10, PTQ, CERQ and POMS-58. Three questionswere
used to access difficulties in initiating sleep (DIS), maintaining sleep
(DMS) and early morning wakening (EMA). A Sleep Difficulties
Index (SDI) was calculated by summing DIS, DMS and EMA scores.
Results In total sample, the multiple linear regression explained
27.7% of the SDI total variance (R2 = .277, F (9, 375) = 15,942,
P < .0001). The significant predictors of the total variance of SDI
were perceived distress (B = .246, P = .0001), repetitive thought
(B = .189, P = .005), cognitive interference and unproductiveness
(B = −.188, P = .006), rumination (B = .130, P = .044) and negative
affect (B = .156, P = .018).
Conclusions Preventive interventions focused on predictor fac-
tors (perceived stress, perseverative thinking, rumination and
negative affect) should be considered in order to promote better
mental health in college students.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O036
Ultra high risk status and transition to
psychosis in 22q11.2 deletion
syndrome
M. Armando ∗, M. Schneider , M. Pontillo , S. Vicari ,
M. Debbane , F. Schultze-Lutter , S. Eliez
1 Ospedale Pediatrico Bambino Gesu, Neuroscience, Roma, Italy
2 Center for Contextual Psychiatry, Neuroscience, Leuven, Belgium
3 Developmental Imaging and Psychopathology Lab, Geneva,
Switzerland
4 University hospital of child and adolescence psychiatry and
psychotherapy, University hospital of child and adolescence
psychiatry and psychotherapy, Bern, Switzerland
5 Department of Genetic Medicine and Development, School of
Medicine, Department of Genetic Medicine and Development School
of Medicine, Geneva, Switzerland
∗ Corresponding author.
The 22q11.2 deletion syndrome (22q11DS) is characterized by
high rates of psychotic symptoms and schizophrenia, making this
condition a promising human model for studying risk factors
for psychosis. We explored the predictive value of ultra high-
risk (UHR) criteria in a sample of patients with 22q11DS. We
also examined the additional contribution of sociodemographic,
clinical and cognitive variables to predict transition to psychosis
within amean interval of 32.56176months after initial assessment.