European Psychiatry - Volume 41 - April 2017

87 / 916

25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105 S83
conducted on the impact of COMT functional polymorphism in
22q11DS, suggesting that attenuated psychotic manifestations are
frequent in children and adolescents and represent one of the
strongest predictors for the onset of psychotic disorder.
Objectives We explored possible interaction between COMT
polymorphism and subclinical psychiatric symptoms in a
22q11.2DS cohort of 42 participants aged 6 to 26 years: 17
hemizygosity for COMT-Met and 25 hemizygosity for COMT-Val.
Aims To analyse impact of COMT gene in 22q11DS and its related
psychiatric correlates.
Method Each participant, genotyped for the catechol O-
methyltransferase (COMT) Met/Val polymorphism, underwent
structured psychiatric and cognitive assessment. Analysis of pos-
itive and negative symptoms was performed by the structured
interview for prodromal syndromes (SIPS). Finally, longitudinal
data available in a subsample of 24 individuals were used to explore
the developmental trajectories of psychotic symptoms one year
later.
Results There was a significant positive correlation between
COMT Val polymorphism and positive symptoms; at follow-up, no
significant correlation were found between COMT polymorphism
and psychiatric symptoms. No other significant differences were
found between groups (Comt/Met-Comt/Val) on any other CBCL or
QI score.
Conclusions COMT and additional genes microdeleted might
interact in the susceptibility to schizophrenia in 22q11.2DS: psy-
chotic symptoms might result from an epistatic interaction with
other genes. Moreover, gene-environment, in presence of genetic
vulnerability could increase the risk of schizophrenia in 22q11DS.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O040
Coping victimization among peers in
Spain
E. Magallón-Neri ∗ anneste-Morales Forns
T. Kirchner
1 University of Barcelona, Faculty of Psychology. IR3c, Clinical
Psychology and Psychobiology, Barcelona, Spain
2 University of Barcelona, Clinical Psychology and Psychobiology,
Barcelona, Spain
∗ Corresponding author.
Background Bullying at school and victimization problems in
adolescence have a negative impact in personal identity develop-
ment specifically in mental health field.
Objective To analyze coping profiles used in a communitarian
adolescents sample in relation to victimization among peers and
controlling the other victimization subtypes.
Method From Barcelona Metropolitan area, 1031 adolescents
between 12 and 20 years old participated (37.5% boys; 15.7%
foreigners). The different coping strategies were assessedwith ado-
lescent coping orientation for problem experiences test and the
victimization types with juvenile victimization questionnaire.
Results A 46.2% of adolescents suffered a victimization event by
peers in the last year. As victimization level by peers advance, it
presents an increase of unproductive coping strategies (P < .001; d-
Cohen = 0.92). Regularly women score higher than men in low and
moderate victimization groups (P < .05). However, when it reaches
the highest expression (higher risk profile), unproductive strategies
use in both genders is very similar and significant differences disap-
pear. The results showthat avoidant coping type is associatedwith a
higher rate of victimization by peers. Positive relationship between
previous victimization in other areas and peer victimization rate
was found.
Conclusions It is of high importance to develop and strengthen
coping psychoeducation programs centered in solving this prob-
lem and struggling against victimization consequences by peers in
adolescence. Due to that, increase of this victimization type is very
related to the use of unproductive strategies use and therefore a
coping by avoiding the problem.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O041
Early childcare and trajectories of
behavioral difficulties in children: The
EDEN mother–child cohort study
M. Melchior
Inserm, Pierre Louis Institute of Epidemiology and Public Health,
Paris, France
Background There is no consensus of the relationship between
early childcare and later psychological development.
Methods We studied 1428 children participating in the French
EDEN cohort. Childcare was reported prospectively between ages
4 months and 3 years: childminder, collective care, informal care.
Children’s behavior was assessed by mother-reported strength and
difficulty questionnaire (SDQ) scores at ages 3.5, 5.5 and 8 years.
Trajectories of children’s behavioral difficulties (emotional diffi-
culties, behavioral problems, peer-relations difficulties, symptoms
of hyperactivity and inattention, prosocial behavior) were identi-
fied using group-based trajectory modelling (PROC TRAJ, SAS). To
control for selection and confounding factors, we used propen-
sity scores based on over 30 covariates, included in multinomial
regression models as inverse probability weights of exposure.
Results Compared to children in informal care, those who were
cared for by a childminder or in collective care were less likely
to have peer problems (respectively, ORs for the intermedi-
ate level trajectory = 0.67 [95% IC: 0.47–0.95] and 0.49 [95% IC:
0.34–0.72]; ORs for the high level trajectory = 0.47 [0.27–0.82]
and 0.33 [0.17–0.62]). Collective care was also associated with a
reduced likelihood of intermediate (OR = 0.71 [0.52–0.98]) and high
trajectories of hyperactivity and inattention (OR= 0.50 [0.35–0.81]),
intermediate (OR = 0.58 [0.39–0.88]) and high trajectories of
emotional symptoms (OR = 0.54 [0.32–0.92]) and intermediate
(OR = 0.72 [0.51–1.01]) and high behavioral problems trajectories
(OR = 0.54 [0.34–0.85]).
Conclusion Childcare attendance prior to school entry – particu-
larly collective childcare –may have beneficial effects for children’s
psychological development and peer relations.
Disclosure of interest The author has not supplied his declaration
of competing interest.
O042
Predicting secondary mental health
care use in adolescence using self-,
parent- and teacher-reported problem
behavior in a community-based
record-linkage study
D. Raven ∗ örg isser . Schoevers
A.J. Oldehinkel
1 UMCG, Psychiatry, Groningen, The Netherlands
2 Friesland Mental Health Services, Research and Education,
Leeuwarden, The Netherlands
∗ Corresponding author.
Introduction In adolescence, help-seeking is affected by different
actors. The influence of each actor on help-seeking is often studied
in isolation, or, if multiple informants are included, using only few
assessments of adolescents’ mental health.