European Psychiatry - Volume 41 - April 2017

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S92 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105
O065
Interplay of gut microbiota, body
mass index and depression scores in
anorexia nervosa: Preliminary data
S. Mörkl ∗, S. Lackner , G. Gorkiewicz , K. Kashofer , C. Blesl ,
A. Tmava , A. Oberascher , S. Holasek
1 Medical University of Graz, Psychiatry, Graz, Austria
2 Medical University of Graz, Institute of Pathophysiology and
Immunology, Graz, Austria
3 Medical University of Graz, Institute of Pathology, Graz, Austria
4 Medical University of Graz, Instiute of Pathophysiology and
Immunology, Graz, Austria
∗ Corresponding author.
Introduction Anorexia nervosa (AN) is a lethal psychiatric disease
with only narrow treatment possibilities. Recent study results point
out, that gut microbiota might be a contributing factor in the devel-
opment andpersistence of AN through effects on the gut-brain-axis.
Methods We used 16SRNA sequencing to characterize the com-
position and diversity of the gut microbiota of 18 AN patients, 19
normal weight controls and 19 athletes matched by age using stool
samples. The QIIME-pipeline was used to assess the sequencing
result. All participants completed an activity-questionnaire (IPAQ)
and inventories to measure depression (BDI, HAMD).
Results Kruskal-Wallis test identified significant differences in
alpha-diversity (Chao-1-estimator [P = 0.013], number of observed
species [P = 0.027]) between groups. Spearman-Correlation
revealed a significant correlation of number of observed species
(r = 0.366, P= 0.006) Chao-1-estimator (r = 0.352, P = 0.008) and BMI
Furthermore, a higher BMI was related to lower depression
scores (r= 0.351, P < 0.001). Although there was a tendency of a
negative correlation of BDI-scores and alpha-diversity (r= –0.180,
P = 0.059), correlations with depression scores and IPAQ-scores did
not reach significance level
Conclusions Our preliminary data demonstrate correlations of
alpha-diversity and BMI. Further studies are needed to provide
further insights in AN gut microbiota and its influence factors.
Fig. 1
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O066
The different effect of childhood
trauma on amygdala and
hippocampus in patients with bipolar
disorder and healthy controls
D. Janiri , P. De Rossi , A. Simonetti , G. Spalletta , G. Sani ∗
1 Sapienza University of Rome, NeSMOS, Rome, Italy
2 IRCCS Santa Lucia Foundation, Department of Clinical and
Behavioral Neurology, Rome, Italy
∗ Corresponding author.
Introduction Childhood trauma (CT) is a relevant environmen-
tal stressor for bipolar disorder (BP). Amygdala and hippocampus
are key areas involved both in the pathophysiology of BP and in
mediating the biological response to stress.
Objectives Structural neuroimaging studies help clarifying neural
correlates of the relationship between BP diagnosis and CT.
Aims To verify the impact of CT on amygdala and hippocam-
pus and hippocampal subfields volumes in BP patients and healthy
control (HC).
Methods We assessed 105 outpatients, diagnosedwith BPI or BPII
according to DSM-IV-TR criteria, and 113 HC subjects. History of
CT was obtained using the childhood trauma questionnaire (CTQ).
High-resolution magnetic resonance imaging was performed on all
subjects and volumes of amygdala, hippocampus, nucleus accum-
bens, caudate, pallidum, putamen, thalamus and hippocampal
subfields were measured through FreeSurfer.
Results All deep gray matter structures were smaller in BP than
HC. CT modulated the impact of the diagnosis on bilateral amyg-
dala and hippocampus, in particular on subiculum, presubiculum
and cornu ammonis CA1. It was associated with bilateral decreased
volumes in HC and increased volumes in patients with BP.
Conclusions Childhood trauma impacts on the amygdala and hip-
pocampus, brain areas involved in response to stress and emotion
processing, and specifically on the hippocampal subfields most
implicated in learning trough positive/negative reinforcement.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O067
Prevalence of psychopathological
features in intellectual diability: The
Italian SPAID-G multicentric study
D. Scuticchio ∗, M.O. Bertelli , G. Chiodelli , R. Cavagnola ,
F. Manna
1 CREA Research and Clinical Center–San Sebastiano Foundation,
Misericordia di Firenze, Florence, Italy
2 Fondazione Istituto Ospedaliero di Sospiro Onlus, Fondazione
Istituto Ospedaliero di Sospiro Onlus, Cremona, Italy
3 Istituto Opera Don Guanella, Istituto Opera Don Guanella, Roma,
Italy
∗ Corresponding author.
Introduction Despite increasing awareness of high prevalence
of psychiatric disorders in people with intellectual disability (ID),
diagnostic tools are few and scarcely used in daily practice.
SPAID-G (psychiatric instrument for the intellectually disabled
adult-general version) is the first Italian for carrying out psychi-
atric diagnostic orientations in adults with ID. It was designed to
be easy and quick instrument for daily clinical practice.
Objectives/Aims The present study was aimed at evaluating psy-
chometric and psychodiagnostic characteristics of the SPAID-G and
at supplying new data on the prevalence rate of psychiatric disor-
ders in a multicentric Italian sample of people with ID living in
different settings.
Methods The SPAID-G was consecutively administered to more
than 800 persons with ID attending residential, rehabilitative or