European Psychiatry - Volume 41 - April 2017

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S98 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105
O081
Current smoking in real world
schizophrenia: Relationship to
psychopathology and clinical
characteristics. Results from the FACE
dataset
J. Mallet ∗, G. Fond , Y. Le-Strat , P.-M. Llorca , C. Dubertret
1 Hospital Louis-Mourier–University Paris Diderot, AP–HP and
Fondation FondaMental and Inserm U894, Department of Psychiatry,
Paris, France
2 GHU Créteil Mondor–Créteil, AP–HP and Fondation FondaMental,
Department of Psychiatry, Créteil, France
3 Hospital Louis-Mourier–University Paris Diderot–Colombes, AP–HP
and Inserm U894, Department of Psychiatry, Colombes, France
4 CHU Clermont-ferrand–Université d’Auvergne and Fondation
FondaMental, Department of Psychiatry, Clermont-Ferrand, France
5 Hospital Louis-Mourier–University Paris diderot, AP–HP and Inserm
U894 and Fondation FondaMental, Department of Psychiatry,
Colombes, France
∗ Corresponding author.
Background Tobacco smoking is common in schizophrenia. Some
characteristics are usually associated to tobacco smoking in
schizophrenia, such as younger age, earlier onset of the disease,
number of hospitalizations or higher treatment doses. However,
little is known about positive symptoms or aggressiveness, as well
as trauma history.
Objectives to study the relationship between smoking status and
clinical characteristics in patients with schizophrenia.
Method A total of 474 patients with were consecutively
included in the network of FondaMental Expert Center (FACE)
for schizophrenia and assessed with the structural clinical inter-
view for DSM-IV axis 1 disorders (SCID), validated scales for
psychotic symptomatology and childhood trauma questionnaire.
Tobacco abuse or dependence was defined according to the
SCID. Ongoing antipsychotic treatment was recorded. Aggressive-
ness was measured with Buss-Perry Aggression Questionnaire
(BPAQ).
Results A sample of 474 patients with schizophrenia was
included in this study (non-smokers, n = 215; non-smokers,
n = 259). Mean age at tobacco onset was 17.19 years old (SD = 3.93).
In multivariate analysis, smoking was associated with SGA
use (P= 0.028), with higher scores of physical aggressiveness
(P = 0.042), with current alcohol-dependence (P= 0.002). However,
no association was observed with sex, age of onset, trauma history,
global functioning, observance or psychotic symptomatology.
Conclusions Tobacco smoking was associated with physical
aggressiveness, but not with earlier onset of the disease nor
traumas or psychotic symptomatology. Besides, the results of
the present study are in favor of a superior efficacy of second-
generation antipsychotics in the treatment of comorbid tobacco
use. These results need further investigation in longitudinal studies.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O082
How could affect stress, PEP and sex in
working memory?
C.-R. Maria Isabel ∗, C.-R. Manuel , M. Andrea , R.-V. Miguel
1 Hospital Virgen del Rocio, Psychiatry, Sevilla, Spain
2 Hospital Virgen del Rocio, Mental Health, Sevilla, Spain
∗ Corresponding author.
Background The first episode of psychosis is a crucial period
when early intervention can alter the trajectory of the young
person’s ongoing mental health and general functioning. Cogni-
tive abilities are nuclear for the social recovery. Stress impairs
higher cognitive processes, dependent on the prefrontal cortex
(PFC) and that involve maintenance and integration of information
over extended periods, including working memory and attention.
Different mechanism are involved such as HPA-Axis hyperactivity,
affecting PFC. Recently, investigations show the different evolution
of cognitive abilities between different sex in WM.
Methods A sample of 41 FEPs and 39 healthy subjects were eval-
uated. The variables assessed were verbal and visual memory,
attention, working memory, processing speed, mental flexibility,
verbal fluency, motor coordination, planning ability and intelli-
gence.
Results We found an interaction between age (< 16 years and
> 16 years) and group (psychosis vs. controls) in working memory
(P = 0.04). There were no difference in men < 16 years old con-
trol group and men with same age plus psychosis (5.87 ±1.57 vs.
5.83 ±1; P = 0.1) inWM. However, this work was found to be signif-
icantly different in the univariant analysis of working memory in
the group < 16 years old women control (7.30 ±1.56) and women
psychosis group (5.61 ± 1.91).
Conclusion Social cognition and stress seem to be directly rela-
tion. Some studies show that stress enhance cognition performance
inmenwhile impairing it inwomen. Stress affect a variety of cogni-
tive processes such attention andworkingmemory. Deficit in social
cognition are present in the prodromal phases of psychosis.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O083
Identification of novel genes
associated to major mental disease by
whole exome sequencing in families
with high prevalence
J. Pol Fuster ∗ uiz Guerra rtega Vila Medina Dols
B. Bisbal Carrió ladó Olmos Heine Su˜ner
F. Ca˜nellas ives Bauzà
1 Hospital Universitario Son Espases, Research Unit, Palma de
Mallorca, Illes Balea, Spain
2 Universitat de les Illes Balears, Biologia, Palma de Mallorca, Spain
3 Hospital Universitario Son Espases, Servicio de Genética, Palma de
Mallorca, Illes Balea, Spain
4 Hospital Universitario Son Espases, Servicio de Psiquiatría, Palma de
Mallorca, Illes Balea, Spain
∗ Corresponding author.
Introduction The identification of new genetic variants underly-
ing psychosis is crucial to improve its molecular diagnosis and to
determine the disease etiology, which is necessary to develop new
therapeutic targets.
Aim To identify novel rare genetic variants associated to mental
disorders, using whole exome sequencing (WES).
Methods Two families with high prevalence of mental disease
were genotyped using WES. The first family has 5 members
affected, the mother with a bipolar disorder, three sons, two with
schizophrenia and one with schizoaffective disorder, and a cousin
withmajor depression and psychotic symptoms. The second family
is constituted by 38 members affected by major mental diseases in
three generations. Key affectedmembers of each familywere geno-
typed by WES. Shared rare variants, with allelic frequencies below
0.5% in general population, were identified among the affected
members of the family. The segregation of those variants was con-
firmed by Sanger sequencing.
Results In family 1, thirty-seven genetic variants related to neu-
rodevelopment were identified. Two of those variants in the genes
TRIP12 and RNF25 segregatedwith psychosis. In family 2, seven rare
genetic variants contained in genes related to neurodevelopment
were identified. A mutation in the gene ARHGAP19 segregated with
psychosis.