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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105



University of Bern, Translational Research Center–University

Hospital of Psychiatry and Psychotherapy, Bern, Switzerland


University of Rome Tor Vergata, Department of Systems Medicine,

Rome, Italy


University of Foggia, Department of Clinical and Experimental

Medicine–Psychiatry Unit, Foggia, Italy

Corresponding author.


Negative symptoms are a core feature of

schizophrenia but their pathophysiology remains elusive. They

cluster in a motivation-related domain, including apathy, anhe-

donia, asociality and in an expression-related domain, including

alogia and blunted affect.


Our aim was to investigate the different neurobiologi-

cal underpinnings of the two domains using the brain electrical

microstates (MS), which reflect global patterns of functional con-

nectivity with high temporal resolution.


We recorded multichannel resting EEGs in 142

schizophrenia patients (SCZ) and in 64 healthy controls (HC),

recruited to the Italian network for research on psychoses study.

Four microstates (MS) classes were computed from resting EEG

data using the K-Mean clustering algorithm. Pearson’s coefficient

was used to investigate correlations of microstates measures

with negative symptom domains, assessed by the Brief Negative

Symptoms Scale (BNSS).


SCZ, in comparison to HC, showed increased contribu-

tion and duration of MS-C. Only the avolition domain of BNSS

correlated with the contribution and occurrence of MS-A. Within

the same domain, anticipatory anhedonia, apathy and asociality,

but not consummatory anhedonia, were positively correlated with

contribution and occurrence of microstate A. Asociality was also

negatively correlated with contribution and occurrence of MS-D.


Our findings support different neurobiological under-

pinnings of the negative symptom domains, avolition and

expressive deficit. Furthermore, our results lend support to the

hypothesis that only anticipatory anhedonia is linked to the avo-

lition domain of the negative symptoms. Mixed results in the

literature concerning the presence of MS-A and D abnormalities

in schizophrenia might be related to the syndrome heterogeneity.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Anticipating outcome: Predictors of

first and subsequent relapses in

schizoprenia. A 3-year follow-up

M. Gomez Revuelta

1 ,

, V . G

ajardo Galan

2 , M.

Juncal Ruiz

2 ,

O. Porta Olivares

2 , R. L

andera Rodriguez

2 ,

G. Pardo De Santayana Jenaro

2 , L. G

arcia Ayala

3 ,

L. Sanchez Blanco

2 , M.

Fernandez Rodriguez

2 , B. C

respo Facorro



Hospital Universitario de Álava-Sede Santiago- Vitoria-Gasteiz,

Psychiatry, La Penilla, Spain


Hospital Universitario Marques de Valdecilla, Psychiatry,

Santander, Spain


Hospital Universitario de Álava-Sede Santiago, Psychiatry,

Vitoria-Gasteiz, Spain

Corresponding author.


Relapse prevention during early stages after psy-

chosis onset is a key factor for long term outcome. While factors

associatedwith first relapse have beenwidely studied, factors asso-

ciated with subsequent relapses are poorly described.


To determine predictive factors of first and subse-

quent relapses among patients recruited from a cohort of PAFIP

Early Intervention Program.

Material and methods

We analyzed socio-demographic and clin-

ical data of a cohort of 393 first episode psychosis (FEP) patients

that were recruited since February 2001 to May 2011. Of these, 341

achieved clinical remission and were, therefore, considered to be

at risk of relapse. They were followed-up for 3 years. A wide range

of potential factors were included as possible predictors of relapse.

Test univariate, analysis logistics of regression, regression of Cox

and analysis of survival of Kaplan-Meier were carried out.


Poor adherence to medication was the main predictor

associated to first relapse (ExpB: 2.979;


< 0.001). After the first

relapse, only 56 patients (33.9%) underwent a second relapse, being

the diagnosis (ExpB: 1.975;


= 0.074), the age of onset, (ExpB:



= 0.003) and a low level of positive symptomatology (ExpB:



= 0.03) the predictors of associated with a second relapse.


After a FEP, non-adherence tomedication is themain

predictor of first relapse. Second and subsequent relapses relate

with non-modifiable factors such as age of onset or schizophrenia

diagnosis. This subgroup of patients could have greater predispo-

sition to relapse related with the severity of the disease itself.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Needs of people with

schizophrenia/psychosis and their

caregivers: A large scale survey

G. Lahera

1 ,

, J. Cid


, A. González-Pinto


, A. Cabrera



I. González


, E. Vieta


, C. Arango


, B. Crespo-Facorro



University of Alcalá–CIBERSAM, Psychiatry, Alcalá de Henares,

Madrid, Spain


Girona Institute of Health Assistance IdibGi, Mental Health, Girona,



Álava University Hospital–CIBERSAM, Psychiatry, Vitoria, Spain


Madrid Association of Friends and Relatives of People with

Schizophrenia, Mental Health, Madrid, Spain


Spanish Mental Health Confederation, Mental Health, Madrid, Spain


Institut of Neuroscience–Hospital Clinic–University of

Barcelona–IDIBAPS–CIBERSAM, Psychiatry, Barcelona, Spain


Gregorio Mara˜nón University Hospital–Complutense University of

Madrid–IiSGM–CIBERSAM, Psychiatry, Madrid, Spain


Marqués de Valdecilla University Hospital–University of

Cantabria–CIBERSAM, Psychiatry, Santander, Spain

Corresponding author.

For the first time in Spain, a large scale survey (5205 people) was

carried out to establish the real needs of those directly affected by

the illness. Patients and caregivers responded to a 9-question sur-

vey concerning dimensions: personal, social, medical treatment,

psychotherapy and rehabilitation. For patients, the most impor-

tant need (an average score of 3.5 on a scale of importance from 1

to 4) was to feel their emotional needs covered. The following aver-

age scores were also obtained: feel well physically (3.42), improve

autonomy (3.41), have leisure activities (3.21) and work/study

(3.1). A total of 42% of patients indicated having little or no freedom

over their lives. Thirty-six percent indicated that medical treat-

ment did not start soon enough, 35% that psychotherapy started

too late and 13% saying they had received no psychotherapy at all.

The help from professionals most valued was provide information

about the illness (3.4), dedicatingmore time (3.4) investigating new

treatments (3.3) paying attention to secondary effects (3.3) and

incorporating the patient in decision making (3.3). Most patients

reported a state of health “regular to good” but 10% indicated not

being understood at all in their social environment since onset

of illness and 25% being little understood. The anti-stigma ini-

tiative most valued was to increase investment in schizophrenia

in health planning. Integral health planning should incorporate

patient insights concerning basic needs and treatment preferences.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.