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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105



Three new genes have been found to be associ-

ated with psychosis.




encode two E3-ubiquitin

ligases which modulate the Wnt pathway, mutations in which

lead to neurodevelopmental defects.


encodes a GTPase

which regulates the RhoA protein, involved in the regulation of the


Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


L-dopa modulates striatal functional

connectivity in adults with

psychotic-like experiences:

A randomized double-blind

placebo-controlled study

J. Rössler

1 ,

, L. Unterrassner


, T. Wyss


, H. Haker


, P. Brugger



W. Rössler


, D. Wotruba



University of Zurich, Collegium Helveticum, Zurich, Switzerland


Institute for Biomedical Engineering–University of Zurich and ETH

Zurich, Translational Neuromodeling Unit TNU, Zurich, Switzerland


University Hospital Zurich, Department of Neurology, Zurich,



Swiss Federal Institute of Technology ETH, Collegium Helveticum,

Zurich, Switzerland

Corresponding author.


According to the dopamine hypothesis functional

brain abnormalities and neurochemical alterations may converge

to cause psychosis through aberrant salience attribution. Indeed,

resting-state functional magnetic resonance imaging (rs-fMRI) has

revealed widespread brain disconnectivity across the psychotic



To advance the understanding of the dopaminergic

involvement in intrinsic functional connectivity (iFC) and its puta-

tive relationship to the development of psychotic disorders we

aimed to investigate the link between L-Dopa, a dopamine pre-

cursor, and its modulation of striatal iFC in subthreshold psychosis,

i.e. non-clinical psychosis.


We used a randomized, double-blind placebo con-

trolled study design including in our sample 56 healthy, male,

right-handed, subjects with no familiar risk factors for psychosis

who were assessed with the Schizotypal Personality Questionnaire

(SPQ) and underwent 10minutes of rs-fMRI scanning. All subjects

received either 250mg of Madopar DR


(200mg L-Dopa plus 50mg

benserazid, dual release form) or a placebo. We analysed resting-

state iFC of 6 striatal seeds, known to evoke dopamine related



The main effect of L-Dopa presented itself (FWE-

corrected) as a significant decrease in iFC from the right ventral

striatum to the cerebellum and the precuneus cortex, and an

increase in iFC to the occipital cortex. Subjects with high SPQ pos-

itive symptom sub-scores showed a significant increase of L-Dopa

induced connectivity.


We identified striatal functional connectivity being

modulated by augmented dopamine availability, and in support

of the dopamine hypothesis, we found that those iFC patterns are

associated to high scores of psychotic like experiences.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


5-years follow-up of antipsychotic

medication and hospitalizations after

first episode hospital-treated

psychosis in a Swedish nation-wide


P. Strålin

1 ,

, J. Hetta



Karolinska University hospital, Psychiatry, Stockholm, Sweden


Karolinska Institutet, Clinical Neuroscience/Psychiatry, Stockholm,


Corresponding author.


Outcome after first episode psychosis is heteroge-

neous, but knowledge about the distribution and predictive factors

is limited.


To investigate medication and rehospitalizations for

five years after first episode hospital treated psychosis.


Swedish population registers were used to select a

nation-wide cohort of 962 cases (589 or 61% men) with a first

hospitalization for psychosis at ages between 16–25 years. Cases

were categorized year by year for 5 years after the initial hospi-

talization with regard to rehospitalizations and dispensations of

antipsychotics and other medications.


The 5-years mortality was 4% (


= 39) with suicides in 16

cases (1.6%, 11 of which were men). Additionally, 139 cases (23% of

women and 10% of men) had hospitalizations for suicide attempts

within 5 years. A bimodal distribution of years with medication

was found indicating two different trajectories of outcome. One

peak was seen for cases with dispensations of antipsychotics 5 of 5

years (40% of the cohort). Another peak was seen at dispensations

during atmost 1 of 5 year (30%). During year 5, 514 (56% of 923 cases

surviving 5 years) had dispensations of neuroleptics and 257 (28%)

were hospitalized, whereas 356 cases (39%) had no dispensation of

neuroleptics or hospitalization.


The population of young cases with first episode

psychosis is heterogeneous with at least two clearly separable

trajectories based on medication and hospitalizations. The high

mortality and high incidence of suicide attempts during a five-year

period demonstrate a need for careful monitoring of these patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Cognitive screening scale for

schizophrenia (CSSS):

The development and the structure of

the scale

A. Szulc

, J. Gierus , T. Koweszko , A. Mosiolek

Medical University of Warsaw, Department of Psychiatry, Pruszkow,


Corresponding author.


The study presents the construction of CSSS: a short

screening scale intended for diagnosis of cognitive deficits among

people with schizophrenia. The final version of the scale consist of

6 subscales which measure basic cognitive functions.


A total of 160 persons (124 with schizophrenia and 36

healthy controls) were tested using the initial version of the CSSS

scale consisting of 11 subscales. Correlation analysis between the

subscale resultswas carried out, aswell as confirmatory factor anal-

ysis, internal consistency analysis of the scale, IRT (item response

theory) analysis of the item’s difficulty, and analysis of the scale’s

accuracy as a classifier.


One factor explains 37% of the variance of the subscales’

results. The scale has satisfactory internal consistency (0,83). Sub-

jects with schizophrenia achieved significantly lower scores than