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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105


reflect the relevance of resilient coping in the activation of non-kin

relationships in old age.


Personal social networks; Ego-centred networks;

Resilient coping; Elderly

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Being afraid of compassion: Fears of

compassion as mediators between

early emotional memories and

psychopathological symptoms in


M. Matos

, J. Duarte , J. Pinto-Gouveia

University of Coimbra, Cognitive and Behavioral Centre for Research

and Intervention CINEICC University of Coimbra, Coimbra, Portugal

Corresponding author.


There is evidence suggesting that for some individ-

uals self-generating compassion and being open to compassion

from others can be difficult or aversive. To date, however, no study

has explored how these fears of compassion are associated with

early emotional memories, such as shame or safeness memories,

and to symptoms of depression and anxiety in adulthood. The cur-

rent study set out to investigate the mediator effect of fears of

compassion on the relationship between the traumatic and cen-

trality features of shame memories, early memories of warmth and

safeness, and symptoms of depression and anxiety.


In this cross-sectional study, participants were 302 indi-

viduals (171 women; age M= 36.28; SD = 11.45) recruited from the

general community population, who completed self-report meas-

ures of fears of compassion (for self, for others and from others),

shame memories, safeness memories, depression and anxiety.


Path analysis showed that fears of compassion for self and

of receiving compassion from others mediated the effects of shame

traumatic memory, centrality of shame memory and early memo-

ries of warmth and safeness on depressive and anxiety symptoms.

Fear of compassion for self was the best predictor of depression and



Fears of compassion may render an individual more

vulnerable to defeat and threat responses when faced with stress-

ful life events, which can manifest as symptoms of depression or

anxiety. Clinical implications might be derived from these findings

as these fears, as well as the negative emotional memories fuelling

them, may need to be addressed in therapy to assist patients in

self-generating and receiving compassion.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Oral communications: Rehabilitation and

psychoeducation and schizophrenia and other

psychotic disorders


Genetic counselling in psychiatric

disorder with high suicide risk

D. Cozman

1 ,

, R. Moldovan


, B. Nemes



Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca,

Department of Medical Psychology, Cluj-Napoca, Romania


Babes-Bolyai University Cluj-Napoca, Psychology, Cluj-Napoca,


Corresponding author.


A better understanding of the genomics of mental

illnesses allowed genetic counselling to be provided to individuals

with severe mental illness and their families.


The present study was aimed at assessing the efficacy of

genetic counselling for severe mental illnesses with high suicide



Assessment was performed before and after genetic

counselling session. Measures used were evaluation of traumatic

events in childhood, multidimensional scale for perception of social

support (SMSSP), positive and negative affect schedule (PANAS-

X), Brief Psychiatric Rating Scale (BPRS), Paykel questionnaire and

Genetic Counselling Outcome Scale (GCOS). Paykel’s questionnaire

consists of five questions about suicidal thoughts and attempts,

including: life-weariness, death wishes, suicidal ideation, suicidal

plans and suicide attempts. Intervention and assessment lasted

approximately one and a half hour. Data from 48 patients was



Mean age of participants was M= 38.4, SD = 9.7, and the

group was batter represented by females (57%). The participants

had various diagnoses, 22% had schizophrenia, 36% bipolar disorder

and 42% recurrent depressive disorder. Forty percent of partici-

pants reported suicidal ideation and 22,5% had a past history of

suicide attempt. Genetic counselling had a direct positive influence

upon GCOS specific items and reduced the Paykel scores among

participants presenting with suicidal ideation.


Genetic counselling offers information about the dis-

order, the role of genetics and the impact of environmental

factors. Preliminary data suggest that providing genetic counselling

decreases the suicidal ideation frequency.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Analysing CYP2D6*4 Allele frequency

in patients with schizophrenia

V. Djordjevic

1 ,

, T. Jevtovic Stoimenov



Clinical center Nis, Daily hospital, Nis, Serbia


Medical Faculty, Institute of Biochemistry, Nis, Serbia

Corresponding author.


Schizophrenia is treated with antipsychotics and

other psychotropic medications, many of which are substrates for

the highly polymorphic CYP2D6 enzyme. Themost frequent variant

allele is CYP2D6*4- leading cause of poor metabolism (PM) pheno-

type. PM causes the reduction of therapeutic response, increase the

risk of adverse drug reactions and increase the plasma concentra-

tion of both drug and its metabolites above the levels of toxicity.

The Aim

Analysing CYP2D6*4 allele frequency among

schizophrenic patients for further individualisation and ratio-

nalisation of therapy.

Patients and methods

Research was conducted on 38

schizophrenic patients and 110 healthy individuals. CYP2D6*4

allele was detected with allele specific PCR.


Bothwild type allele carriers are 55% of the schizophrenic

patients, 45% are wild type/*4heterozygous, and *4/*4 homozygous

are not identified. There is a statistically significant difference in the

genotype distribution (


< 0.05) between schizophrenic patients

and healthy individuals. Significantly higher *4 allele frequency

(37%) comparing to healthy individuals (


< 0.0001) indicates the

necessary caution in administration of CYP2D6 substrates. A lower

frequency of PMs in schizophrenic patients than in healthy indi-

viduals could be explained with CYP2D6 neuroactive substrate

metabolism. Forty-five percent of the schizophrenic patients are

intermediate metabolisers carrying the higher risk of adverse