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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105



Our preliminary findings suggest that





gene could be involved in modulating the susceptibility of BD

patients to develop renal dysfunctions induced by chronic Li treat-


Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Association between two

single-nucleotide polymorphism of


gene and suicide attempts

A. Zdanowicz

1 ,

, A. Sakowicz


, E. Kusidel


, P. Wierzbinski



Medical University, Department of Adult Psychiatry, Lodz, Poland


Medical University, Department of Medical Biotechnology, Lodz,



University of Lodz, Department of Spatial Econometrics, Lodz,



Medsolver- Psychological and Psychiatric Clinic, Lodz, Poland

Corresponding author.

Introduction TAAR1

is a G protein-coupled receptor expressed

broadly throughout the brain. Recently,


has been demon-

strated to be an important modulator of the dopaminergic,

serotonergic and glutamatergic activity.


Assessment of the relation between two single-nucleotide

polymorphisms of


gene, suicide attempts and alcohol abuse.


A total of 150 Polish patients were included, 59 sub-

jects after suicide attempt vs. 91 controls. The chosen SNPs

(rs759733834 and rs9402439) were studied using RFLP-PCR meth-

ods. The Hardy-Weinberg equilibrium was tested in control group.

Statistical tests



or Yeates Chi


Test were used.


The mean age of study subjects and controls was:



12.3 and 42


12.8 respectively; 49% study males vs. 54% male

controls. We did not observe the association between the carriage

of the genotypes GG, GA and AA of rs759733834 polymorphisms

in either of the groups. The distribution of genotypes in respect

to rs9402439 polymorphism (CC, CG, GG) was also insignificant.

Among patients with alcohol dependence, the frequency G allele

of rs9402439 polymorphismwas lower compared to non-addicted

ones (27 vs. 47%)


< 0.01.

Conclusions TAAR1

polymorphisms rs759733834 and rs9402439

are not related to suicide attempts. The carriage of allele G of

rs9402439 polymorphism is related to lower risk of alcohol addic-

tion OR 0.40 95%Cl 0.20–0.81. To our knowledge, this is the first

study on the


receptor and the risk of suicide and it might

offer a new insight into genetic etiology of



Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Verbal learning and memory in at-risk

mental state and first episode

psychosis patients and their correlates

to brain structural alterations

L. Egloff

, C. L

enz , E. Studerus , U. Heitz , S. Menghini-Müller ,

F. Harrisberger , S. Ittig , K. Beck , L. Leanza , C. Andreou ,

A. Riecher-Rössler , S. Borgwardt

University of Basel Psychiatric Hospital, Department of Psychiatry,

Basel, Switzerland

Corresponding author.


Patients with a first episode psychosis (FEP) have

repeatedly been shown to have gray matter (GM) volume alter-

ations. Some of these neuroanatomical abnormalities are already

evident in the at-risk mental state (ARMS) for psychosis. Not only

GM alterations but also neurocognitive impairments predate the

onset of frank psychosis with verbal learning and memory (VLM)

being among themost impaireddomains. Yet, their interconnection

with alterations in GM volumes remains ambiguous.


To evaluate associations of different subcortical GM

volumes in the medial temporal lobe with VLM performance in

ARMS and FEP patients.


Data were collected within the prospective Früherken-

nung von Psychosen (FePsy) study, which aims to improve the early

detection of psychosis. VLM was assessed using the California Ver-

bal Learning Test (CVLT) and its latent variables Attention Span

(AS), Learning Efficiency (LE), Delayed Memory (DM) and Inaccu-

rate Memory (IM). Structural images were acquired using a 3 Tesla

magnetic resonance imaging scanner.


Data from 59 ARMS and 47 FEP patients were ana-

lysed. Structural equation models revealed significant associations

between the amygdala and AS, LE and IM; thalamus and LE and IM;

and the caudate, hippocampus and putamen with IM. However,

none of these significant results withstood correction for multiple



Although VLM is among themost impaired cognitive

domains in emerging psychosis, we could not find an association

between lowperformance in this domain and reductions in subcor-

tical GM volumes. Our results suggest that deficits in this domain

may not stem from alterations in subcortical structures.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


The effects of deep-brain magnetic

stimulation (DMS) on white matter

deficits: New mechanism in major

depressive disorder (MDD) treatment

Y. Zhang

1 , D.


2 , S. F


3 , H.


2 , H.


4 , R. B


1 ,

X.M. Li

2 ,


University of Saskatchewan, Department of Psychiatry, Saskatoon,



University of Alberta, Department of Psychiatry, Edmonton, Canada


Fourth Military Medical University, Department of Psychiatry,

Xi’An, China


Xinxiang Medical University, Department of Psychology, Xinxiang,


Corresponding author.

Deep-brain magnetic stimulation (DMS) is an effective therapy

for various neuropsychiatric disorders including major depression

disorder. The molecular and cellular mechanisms underlying the

impacts of DMS on the brain remain unclear. Studies have reported

abnormalities in the white matter of depressive brains, suggest-

ing the involvement of myelin and oligodendrocyte pathologies

in the development of major depressive disorder. In this study,

we use a cuprizone induced demyelination animal model to

generate depressive like behaviours and white matter and oligo-

dendrocyte damages. Meanwhile, we treated the animal with

DMS 20minutes daily during the cuprizone challenge or recovery

period. Behavioural tests, including nesting, new objective recog-

nition, working memory and depression-like behaviours were

tested periodically. Histological staining and western blotting were

used to examine the underlying mechanism of DMS. We found

that DMS reverse cuprizone induced behavioural deficits in acute

demyelination but not during the recovery period. DMS alleviated

demyelination and inflammation induced by cuprizone. During the

recovery period, DMS had no impacts on overall neural progenitor

cell proliferation, but enhanced the maturation of oligodendrocyte.

This data suggest that DMS may be a promising treatment option

for improving white matter function in psychiatric disorders and

neurological diseases in future.