Table of Contents Table of Contents
Previous Page  116 / 916 Next Page
Show Menu
Previous Page 116 / 916 Next Page
Page Background


25th European Congress of Psychiatry / European Psychiatry 41S (2017) S106–S169


Several studies have shown effect of CBT for HA-

patients. However, these effects have been short or immediate after

therapy. To our knowledge no studies have examined long-term

effect of CBT for HA over 18months.


To investigate the long-term effect of CBT on HA, focusing

on level of HA, quality of life, subjective health complaints and gen-

eral anxiety. Follow-up time was at least 10 years. Our hypothesis

was that the effect was sustained.


Patients with HA received 16 sessions of CBT over a

period of 12–18 months, and were followed up over at least 10

years. All patients fulfilled criteria for F45.2, hypochondriacal dis-

order according to ICD-10.

The patients answered several questionnaires, exploring areas such

as HA, Quality of life, somatization, and mental health problems.

Questionnaires were answered before CBT, after CBT and at follow

up. Mixed model analysis was performed in SPSS 23.0 for all ques-



All scores were found to be significant in the Pre-

CBT–Post-CBT and Pre-CBT–FU (0.034– < 0.001), and none were

found to be significant in the Post-CBT–FU.


Our findings suggest that for the majority of patients

with HA, CBT has a significant and lasting long-term effect. This

effect lasts up to ten years post therapy.

Disclosure of interest

The author has not supplied his/her decla-

ration of competing interest.

e-Poster walk: Bipolar disorders - part 1


Metabolic syndrome in patients with

bipolar disorder treated with atypical

antipsychotics, their first-degree

relatives and control group

S. Ary

a 1 ,

, H .


1 , B. A




Iran University of Medical Sciences, Mental Health Research Center,

Tehran, Iran


Golestan University of Medical Sciences, Department of General

Surgery, Gorgan, Iran

Corresponding author.

Introduction and objective

Patients with serious mental illness

have lower life expectancy and higher prevalence of metabolic syn-

drome compared to normal population. Although, we have little

evidence about their first-degree relatives.


To compare metabolic syndrome in patients with bipolar

disorder treatedwith atypical antipsychotics, their first degree rela-

tives and healthy subjects in two age groups: under and over 40.


This cross-sectional study was conducted on 100

patients with bipolar disorder treated with atypical antipsychotics,

50 first degree relatives and 135 healthy subjects. The prevalence

of metabolic syndrome was assessed based on National Cholesterol

Education Program (NCEP).


Under the age of 40, the prevalence of metabolic syn-

drome was 15.4% in patients with Bipolar disorder, 17.6% in first

degree relatives and 7% in healthy subjects. Systolic blood pressure

was significantly higher in bipolar disorder patients (


= 0.004). In

those over 40, the prevalence of metabolic syndrome was 31.8% in

patients with bipolar disorder, 33.3% in first-degree relatives and

32.8% in healthy subjects. Serum levels of HDL were significantly

lower in bipolar disorder patients (


= 0.002).


Patients with bipolar disorder and their first-degree

relatives have greater chance for cardiovascular disease due to

higher metabolic syndrome. Further investigations are needed for

evaluating serious mental illness patients and their relatives.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


The effect of long-term lithium

treatment on renal functions in

patients with bipolar disorder

B. Ayik

1 ,

, S . C

¸ akır

1 , H.


2 , S. K




Istanbul Faculty of Medicine, Psychiatry, Istanbul, Turkey


Istanbul Faculty of Medicine, Nephrology, Istanbul, Turkey

Corresponding author.


The effect of lithium on tubular functions leading

to decreased urinary concentrating ability is recognized. Although

there are several studies type, severity and frequency of renal

impairment and its correlation with duration of lithium therapy

are not well established.


To explore long-term effects of lithium on patients

with chronic bipolar disorder.


We aimed to assess patients with bipolar disorder using

lithium at least for six years in terms of renal functions, starting

from mild impairments to full blown chronic renal failure.


Fifty-one patients with bipolar disorder and 38 age and

sex matched healthy controls were enrolled for the study. Serum

BUN, creatinine, uric acid, electrolytes, calcium (Ca), phosphorus

(P), vitamin D (25-OH D3) and eGFR levels were measured. The cor-

relations between renal function and mean lithium levels, duration

of lithium treatment and GAF scores were calculated.


Mean eGFR level of patients with bipolar disorder was

significantly lower than that of controls. Serumcreatinine, uric acid,

Ca and PTH levels were higher, 25-OH D3 levels were lower in the

patients than in controls. The duration of lithium treatment was

positively correlated with serum creatinine and uric acid levels,

negatively correlated with eGFR levels. Mean lithium levels were

positively correlated with serum creatinine levels and negatively

correlated with eGFR.


The study revealed that glomerular functioning of

the patient group was significantly lower than that of the control

group. The findings suggested that both duration of lithium treat-

ment and high serum lithium levels may have a negative impact on

glomerular functions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Protocol for developing and validating

a multivariable prediction model to

individualize the risk of recurrence of

bipolar disorder in the perinatal


M. Casanova Dias

1 ,

, I. Jo


1 , A.

Di Florio

1 , L. J


2 ,

N. Craddock



Cardiff University School of Medicine, MRC Centre for

Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom


Institute of Health & Society, Worcester University, Worcester,

United Kingdom

Corresponding author.


For women with bipolar disorder, childbirth is a

high-risk period with 40–50% experiencing a recurrence and 20%

developing a severe episode of postpartum psychosis. Bipolar

episodes in the perinatal period affect women and their families.