European Psychiatry - Volume 41 - April 2017

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S112 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S106–S169
Objectives Several studies have shown effect of CBT for HA-
patients. However, these effects have been short or immediate after
therapy. To our knowledge no studies have examined long-term
effect of CBT for HA over 18months.
Aims To investigate the long-term effect of CBT on HA, focusing
on level of HA, quality of life, subjective health complaints and gen-
eral anxiety. Follow-up time was at least 10 years. Our hypothesis
was that the effect was sustained.
Methods Patients with HA received 16 sessions of CBT over a
period of 12–18 months, and were followed up over at least 10
years. All patients fulfilled criteria for F45.2, hypochondriacal dis-
order according to ICD-10.
The patients answered several questionnaires, exploring areas such
as HA, Quality of life, somatization, and mental health problems.
Questionnaires were answered before CBT, after CBT and at follow
up. Mixed model analysis was performed in SPSS 23.0 for all ques-
tionnaires.
Results All scores were found to be significant in the Pre-
CBT–Post-CBT and Pre-CBT–FU (0.034– < 0.001), and none were
found to be significant in the Post-CBT–FU.
Conclusions Our findings suggest that for the majority of patients
with HA, CBT has a significant and lasting long-term effect. This
effect lasts up to ten years post therapy.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
e-Poster walk: Bipolar disorders - part 1
EW0019
Metabolic syndrome in patients with
bipolar disorder treated with atypical
antipsychotics, their first-degree
relatives and control group
S. Ary ∗ Ahmadkhaniha rya
1 Iran University of Medical Sciences, Mental Health Research Center,
Tehran, Iran
2 Golestan University of Medical Sciences, Department of General
Surgery, Gorgan, Iran
∗ Corresponding author.
Introduction and objective Patients with serious mental illness
have lower life expectancy and higher prevalence of metabolic syn-
drome compared to normal population. Although, we have little
evidence about their first-degree relatives.
Aims To compare metabolic syndrome in patients with bipolar
disorder treatedwith atypical antipsychotics, their first degree rela-
tives and healthy subjects in two age groups: under and over 40.
Methods This cross-sectional study was conducted on 100
patients with bipolar disorder treated with atypical antipsychotics,
50 first degree relatives and 135 healthy subjects. The prevalence
of metabolic syndrome was assessed based on National Cholesterol
Education Program (NCEP).
Results Under the age of 40, the prevalence of metabolic syn-
drome was 15.4% in patients with Bipolar disorder, 17.6% in first
degree relatives and 7% in healthy subjects. Systolic blood pressure
was significantly higher in bipolar disorder patients (P = 0.004). In
those over 40, the prevalence of metabolic syndrome was 31.8% in
patients with bipolar disorder, 33.3% in first-degree relatives and
32.8% in healthy subjects. Serum levels of HDL were significantly
lower in bipolar disorder patients (P = 0.002).
Conclusion Patients with bipolar disorder and their first-degree
relatives have greater chance for cardiovascular disease due to
higher metabolic syndrome. Further investigations are needed for
evaluating serious mental illness patients and their relatives.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0020
The effect of long-term lithium
treatment on renal functions in
patients with bipolar disorder
B. Ayik ∗ ¸ akır Yazıcı arabulut
1 Istanbul Faculty of Medicine, Psychiatry, Istanbul, Turkey
2 Istanbul Faculty of Medicine, Nephrology, Istanbul, Turkey
∗ Corresponding author.
Introduction The effect of lithium on tubular functions leading
to decreased urinary concentrating ability is recognized. Although
there are several studies type, severity and frequency of renal
impairment and its correlation with duration of lithium therapy
are not well established.
Objectives To explore long-term effects of lithium on patients
with chronic bipolar disorder.
Aims We aimed to assess patients with bipolar disorder using
lithium at least for six years in terms of renal functions, starting
from mild impairments to full blown chronic renal failure.
Methods Fifty-one patients with bipolar disorder and 38 age and
sex matched healthy controls were enrolled for the study. Serum
BUN, creatinine, uric acid, electrolytes, calcium (Ca), phosphorus
(P), vitamin D (25-OH D3) and eGFR levels were measured. The cor-
relations between renal function and mean lithium levels, duration
of lithium treatment and GAF scores were calculated.
Results Mean eGFR level of patients with bipolar disorder was
significantly lower than that of controls. Serumcreatinine, uric acid,
Ca and PTH levels were higher, 25-OH D3 levels were lower in the
patients than in controls. The duration of lithium treatment was
positively correlated with serum creatinine and uric acid levels,
negatively correlated with eGFR levels. Mean lithium levels were
positively correlated with serum creatinine levels and negatively
correlated with eGFR.
Conclusions The study revealed that glomerular functioning of
the patient group was significantly lower than that of the control
group. The findings suggested that both duration of lithium treat-
ment and high serum lithium levels may have a negative impact on
glomerular functions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0021
Protocol for developing and validating
a multivariable prediction model to
individualize the risk of recurrence of
bipolar disorder in the perinatal
period
M. Casanova Dias ∗ nes Di Florio ones
N. Craddock
1 Cardiff University School of Medicine, MRC Centre for
Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom
2 Institute of Health & Society, Worcester University, Worcester,
United Kingdom
∗ Corresponding author.
Introduction For women with bipolar disorder, childbirth is a
high-risk period with 40–50% experiencing a recurrence and 20%
developing a severe episode of postpartum psychosis. Bipolar
episodes in the perinatal period affect women and their families.