European Psychiatry - Volume 41 - April 2017

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S114 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S106–S169
Aim To identify sociodemographic, clinical and therapeutic char-
acteristics in subjects with a late-onset BP.
Patients and methods Retrospective and comparative study of
101 patients followed for a BP (12 patients with BP started after 50
years and 89 patients with BP started earlier) from 2009 to 2015,
in the department of psychiatry of the University Hospital Farhat
Hached, Sousse, Tunisia.
Results The mean age of subjects with late-onset TBP was
46.11 ±12.85 years. Women were in the majority (65.3%). Ten
patients had a novo mania, four patients had a late-onset mania
and one patient had a secondary mania. Regarding the socio-
demographic data, only the regular professional activity was more
reported in the elderly (P = 0.017). Regarding clinical data, BP type 1
and secondary mania were more reported in elderly with (P = 0.050
and P = 0.000 respectively). Elderly had significantly fewer depres-
sive episodes (P = 0.026), fewer hypomanic episodes (P = 0.000).
The durations of the latest episodes and the last intervals were
shorter in elderly (P = 0.045 and P= 0.000). Concerning therapeutic
data, elderly had fewer hospitalizations ( P = 0.045), required lower
mean doses of lithium (P= 0.04) and greater mean doses of tricyclic
antidepressants (P = 0.047).
Conclusion It is always necessary to look for an organic cause in
manic syndrome in late-onset BP. Doses of lithium should be lower.
However, doses of TAD should be higher.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0025
Serum of bipolar patients induces
pro-inflammatory activation of
macrophages
S. Dubou Serafim ∗, P. Ferrari , R. Colombo , L. Paul Géa ,
M. Migliorini Parisi Becker . Ascoli Fries
M. Kauer-Sant’anna apczinski lamt .C.R. Guma
A. Ribeiro Rosa . Barbé-Tuana
1 Universidade Federal do Rio Grande do Sul, Programa de
Pós-Graduac¸ ão em Psiquiatria e Ciências do Comportamento, Porto
Alegre, Brazil
2 Universidade de Caxias do Sul, Laboratory of Pharmacology and
Physiology, Caxias do Sul, Brazil
3 Universidade Federal do Rio Grande do Sul, Department of
Pharmacology and Postgraduate Program: Pharmacology and
Therapeutics, Porto Alegre, Brazil
4 Universidade Federal do Rio Grande do Sul, Postgraduate Program:
Biochemistry, Porto Alegre, Brazil
5 Universidade Federal do Rio Grande do Sul, Laboratory of Molecular
Biology and Bioinformatics, Porto Alegre, Brazil
6 Universidade Federal do Rio Grande do Sul, Department of
Biochemistry, Porto Alegre, Brazil
∗ Corresponding author.
Introduction Evidence has suggested that immune imbalance is
involved with bipolar disorder (BD); however, its precise mecha-
nism is poorly understood.
Objective This study investigated whether biochemical changes
in the serum from BD patients could modulate the phenotype of
macrophages.
Methods Eighteen subjects with BD and healthy individuals
(n = 5) were included in this study. The humanmonocyte cell line U-
937was activatedwith PMA (phorbol 12-myristate 13-acetate) and
polarization was induced with RPMI-1640 media supplemented
with 10% serum from each patient for 24 h. Gene expression of
selected M1 and M2 markers was assessed by qPCR.
Results Macrophages exposed to serum of manic and depres-
sive BD patients displayed an increase of IL-1 (6.40 ±3.47 and
9.04 ± 5.84 versus 0.23± 0.11; P < 0.05) and TNF- (2.23 ± 0.91
and 2.03 ±0.45 versus 0.62 ±0.24; P = 0.002 and P = 0.004, respec-
tively) compared to remitted group. In parallel, U-937macrophages
treated with serum of patients in acute episode displayed a down-
regulation of CXCL9 (0.29 ±0.20 versus 1.86 ±1.61; P = 0.006) and
CXCL10 expression (0.36 ± 0.15 and 0.86 ±0.24 versus 1.83 ±0.88;
P < 0.000 and P = 0.04) compared to remitters.
Conclusions Our results are consistent with previous studies
showing that changes in peripheral blood markers could modu-
late M1/M2 polarization in BD. The evidence of macrophages as
source of inflammatory cytokines might be helpful to unravel how
the mononuclear phagocyte system can be involved in the etiology
of BD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0026
Cognitive functions and cognitive
styles in young euthymic patients
with bipolar I disorder
S. ElGhonemy ∗, P.H. Fakhry , A. Salem
1 Ain Shams University, Neuropsychiatry Department, Cairo, Egypt
2 Cairo University, Psychiatry, Cairo, Egypt
∗ Corresponding author.
Background Cognitive deficits impair patients working and func-
tioning status and may have negative impact on other aspects of
thinking.
Objectives Assess the prevalence of cognitive dysfunction in
patients with bipolar disorder in euthymic state and to explore
cognitive style problems.
Method Case-control naturalistic study, 60 patients with bipolar
I disorder in euthymic state according to DSM-IV were recruited
and subdivided into two groups each contains of 30 patients;
(Group BPM) euthymic patients with recent manic episode, Group
BPD euthymic patients with recent depressive episode. Both
groups were further compared with control group (Group C)
consisted of 30 frequency matched healthy volunteers. Groups
were subjected to the following: (1) clinical psychiatric exam-
ination, (2) (HAMD-17) and Bech–Rafaelsen Melancholia Scale
(MES) for (BPD), (3) (YMRS) and Bech–RafaelsenMania Scale (MAS)
for (BPM), (4) assessment of euthymic state of mood included
both MAS and MES, (5) MMSE, MTS and CDT were performed
to assess cognitive functions, (6) cognitive styles evaluation the
Social Dysfunction and Aggression Scale SDAS-9 and Arabic Anger
Scale.
Results Definite cognitive function impairment and different pat-
terns of cognitive style were detected in case groups. MMSE,
MTS and CDT scores were statistically significant. Fear of Failure
Scale Scores were higher in BPM; 16 (53.33%) reported severe
intensity compared to 16 (53.33%) of BPD Group reporting mod-
erate intensity and 30 (100%) of the control group reporting
only mild intensity of fear of failure with statistically significant
differences.
Conclusions Patients in euthymic state suffer from cognitive dys-
function and some aspects of cognitive styles that negatively
interfere with their performance.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0027
Improving and assessing public
beliefs, knowledge and attitudes
towards bipolar disorder in Pakistan
S. Zaidi
Fatima Jinnah medical university, Sir Ganga Ram hospital, Lahore,
Pakistan