European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S106–S169 S123
Conclusions This work underscores the caregiver’s role as a faci-
litator of child integration and response to sensory stimuli and
its importance on the development of behavioral and emotional
disorders. This can help early diagnosis and better treatment who
prevent future psychiatric conditions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0052
Pediatric autoimmune
neuropsychiatric syndrome (PANS),
developmental regression and autism
S. Bejerot ∗, E. Hesselmark
1 Örebro Universitet, School of Medical Sciences, Örebro, Sweden
2 Karolinska Institutet, Department of Clinical Neuroscience,
Stockholm, Sweden
∗ Corresponding author.
Introduction Pediatric autoimmune neuropsychiatric syndrome
(PANS) is a term used to describe a clinical picture which includes
sudden onset of psychiatric symptoms and a possible autoimmune
genesis. The sudden decline in neuropsychiatric functioning as well
as the multiple combinations of symptoms may lead to a clinical
phenotype similar to that in infantile autism (IA) with regressive
features. We are conducting a study with the aim to evaluate a
diagnostic test for PANS currentlymarketed byMoleculera Labs. All
patients in Sweden who had taken the test (n = 154) were invited
to the study.
Objectives The aim of the study is to characterize a subgroup of
patients with IA within the PANS diagnosis study.
Methods Participants (n = 53) were examined for psychiatric and
somatic symptoms and evaluated for PANS caseness by an experi-
enced psychiatrist. Because the criteria for entering the study was
having taken the diagnostic test for PANS, the participants in the
study comprise a group with mixed symptoms.
Results Twelve participants had IA. Eleven of these reported a
developmental regression with loss of abilities. Two of the IA
patients also fulfill criteria for PANS. Eight of the IA patients had
been treated with antibiotics for psychiatric symptoms and 4
reported a positive effect of this treatment. Nine of the patients
had elevated test results suggesting possible PANS according to
Moleculera Labs.
Conclusions Very early onset on PANS may be phenotypically
similar to IA with regressive features. Further analysis of the
immunological attributes of patients with autism with regressive
features is warranted.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0053
Psychoaffectives repercussions of
autism on parents
R. Ben Soussia ∗ ouallagui , S. Khouadja , I. Marrag , M. Nasr
CHU Tahar Sfar, Psychiatry, Mahdia, Tunisia
∗ Corresponding author.
Introduction Caring for a child with autism is a stressful expe-
rience for parents. The daily stress of this handicap has a major
impact and triggers in the parents a series of adverse psychological
reactions.
Aim To reveal sociodemographic characteristics of parents of
autistic children and to estimate the prevalence of anxiety and
depressive symptoms among these parents.
Methods A cross-sectional study conducted among parents of
autistic children supported by four of autistic children rehabili-
tation centers under the Tunisian Association for the Promotion
of Mental Health. Data were collected through a questionnaire to
explore the sociodemographic data of parents of autistic children.
Depressive symptoms were assessed by the Beck scale and anxiety
symptoms by the Hamilton scale.
Results Fifty-two parents were collected. The middle age was
35.73 years. They lived in an urban area in 96% of cases. Themajority
had an average socioeconomic level (88.4%). The respective rates of
depressed or anxious parents as Beck scales andHamiltonwere 48%
and 23%. The association between depressive and anxious symp-
toms was found in 19%. In addition, depression was more common
in mothers (P < 10−4) and anxiety was also more evident among
mothers (P = 0.01).
Conclusion The presence of an autistic child causes profound
changes in families and can be a source of tension and stress.
The anxious and depressive impact on parents is important and
frequent. The intervention that designs the psychiatrist to help chil-
dren with autism should necessarily include an action for parents.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0054
Efficacy of the “cooperative
assessment” diagnostic procedure to
early improve acute symptoms in a
sample of adolescents with anxiety
and mood disorders
M. Biagiarelli ∗, M. Curto , M.P. Andraos , V. Aprile ,
S. Pelaccia , G. Listanti , G. Trabucchi , F.M. Moscati ,
F. Pazzelli , F. Caccia , M. Pezzotti , A. Mazzei , S. Caltagirone ,
P. Girardi , M. Pompili , S. Ferracuti , C. Sarlatto
1 Sapienza University of Rome, Faculty of Medicine and Psychology,
Department of Dynamic and Clinical Psychology, Roma, Italy
2 Sapienza University of Rome, Department of Neurology and
Psychiatry, Roma, Italy
3 Sapienza University of Rome, Dynamic and Clinical Psychology,
Roma, Italy
4 Sapienza University of Rome, Residency of Clinical Assessment,
Roma, Italy
5 Sapienza University of Rome, Psychiatry Residency Training
Program, Faculty of Medicine and Psychology, Roma, Italy
6 Sapienza University of Rome, Psychiatry Residency Training
Program, Faculty of Medicine and Psychology, Roma, Italy
7 Sant’Andrea Hospital, Accademia di psicoterapia della famiglia,
Roma, Italy
8 Sapienza University of Rome, Psychiatry Residency Training
Program, Faculty of Medicine and Psychology, Roma, Italy
9 Sapienza University of Rome, Sant’Andrea Hospital, Psychiatry
Residency Training Program, Faculty of Medicine and Psychology,
Roma, Italy
∗ Corresponding author.
Introduction Anxiety and mood disorders are common in adoles-
cence and predict poor mental health outcomes and low quality of
life in adulthood. Although early intervention seems to be critical,
dropouts in the early stages of treatment are frequent and associ-
atedwith low insight and severe symptoms. Therefore, a diagnostic
assessment phase aimed to increase insight and early reduce symp-
toms appears to be essential in adolescents.
Objectives The objective of this study is to demonstrate that the
diagnostic method Cooperative Assessment is able to early reduce
symptoms in adolescents with anxiety and mood disorders.
Methods A sample of 88 patients, aged 14–19 years were
included. All were recruited at the first visit and evaluated with
the Cooperative Assessment. This manualized procedure was cre-
ated from principles of collaborative and therapeutic assessment
and aim to involve the patient in a co-developed diagnosis thor-