European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237 S225
Aims To assess the prevalence, demographics, clinical correlates
and course of these euphoric versus irritable pediatric mania.
Methods Systematic review of the available studies assessing the
phenomenology, course and outcome of pediatric mania.
Results Eighteen studies reported the number of subjects pre-
senting with either irritable or elated mood during mania.
Irritability has been reported to be the most frequent clinical fea-
ture of pediatric mania reaching a sensitivity of 95–100% in several
samples. Only half the studies reviewed reported on number of
episodes or cycling patterns and the described course was mostly
chronic and ultra-rapid whereas the classical episodic presentation
was less common. Few long-term outcome studies have reported
a diagnostic stability of mania from childhood to young adult age.
Conclusions Severe irritability is the most common presentation
of abnormal mood described in children with bipolar disorder.
Longitudinal studies of samples with irritable versus elated mood
presentation and chronic versus episodic course may help clarify
whether these are factors predicting different long-term course,
treatment-response and outcome of pediatric onset bipolar disor-
der.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
e-poster walk: Classification of mental disorders
and cultural psychiatry
EW0351
Pretreatment predictors of early
response revealed by quantitative
cerebral blood flow in major
depressive disorder
Z. Hou ∗, Z. Wang , W. Jiang , Y. Yin , Y. Yue , Y. Zhang ,
Y. Yuan
1 Zhongda Hospital, Medical School of Southeast University,
Department of Psychosomatics and Psychiatry, Nanjing, China
2 Zhongda Hospital, Medical School of Southeast University,
Department of Neurology, Nanjing, China
∗ Corresponding author.
Objective The potential pattern of regional cerebral blood flow
(rCBF) in major depressive disorder (MDD) underlies different
response to antidepressants medication remain unclear. This study
aimed to investigate the differences of rCBF between patients with
different treatment response.
Methods Eighty MDD patients [(44 treatment-responsive
depression (RD) and 36 non-responding depression (NRD)] and
42 healthy controls (HC) underwent pulsed arterial spin labeling
(PASL) scans in magnetic resonance imaging and clinical esti-
mates. The exact rCBF values of each groups were obtained via
quantification evaluation.
Results Compared to NRD, the RD patients showed decreased
rCBF values in frontal sensorimotor network (i.e. left paracentral
lobule, left medial frontal gyrus, right superior frontal gyrus and
right middle frontal gyrus), and further receiver operating curve
(ROC) analyses demonstrated that the altered rCBF in these four
regions exhibited outstanding performance on distinguishing NRD
from RD. The NRD also exhibited reduced rCBF in bilateral cerebel-
lum posterior lobe and right middle occipital gyrus and elevated
rCBF in right postcentral gyrus and right middle frontal gyrus as
compared to HC.
Conclusions The decreased rCBF in frontal sensorimotor net-
work appeared to be distinct characteristics for NRD, and might
be severed as promising neuroimaging markers to differentiate
depressed patients with weak early response to antidepressant
medication. These findings expand our understanding of neural
substrate underlying the antidepressant efficacy.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0352
Review of Othello syndrome and its
relationship with neurological
disorders
P. Michielsen ∗ e Jonge etrykiv Arts
1 Mental Health Western Northern Brabant, General Adult Psychiatry,
Halsteren, The Netherlands
2 Mental Health Western Northern Brabant, Department of
Neuropsychiatry and Geriatric Psychiatry, Halsteren, The Netherlands
3 University of Groningen, University Medical Center Groningen,
Department of Clinical Pharmacy and Pharmacology, Groningen, The
Netherlands
4 University of Groningen, University Medical Center Groningen,
Department of Old Age Psychiatry, Groningen, The Netherlands
∗ Corresponding author.
Introduction Othello syndrome is a psychotic disorder character-
ized by delusion of infidelity or jealousy. It predominantly occurs in
the context of specific psychiatric or neurological disorders. Othello
syndrome is associated with mental changes including excessive
aggression, hostility, and irritability. Patients with Othello syn-
drome misinterpret the behaviour of the spouse or sexual partner
to provide evidence for their false perception.
Objectives and aims The purpose of this paper is to examine the
phenomenon of Othello syndrome as a result of specific neurolog-
ical diseases.
Methods The study design was a retrospective case series of
patients with Othello syndrome. We searched the electronic
databases PubMed and Embase for review articles and original
research using the search terms ‘Othello syndrome, Morbid Jeal-
ousy, Pathological Jealousy, Delusional Jealousy, Delusions and
Infidelity, Delusions of Jealousy or Infidelity’.
Results In the present study of 95 case reports, the relation-
ship between Othello syndrome and a neurological pathology was
described. This syndrome was most commonly associated with
neurodegenerative diseases (59%), followed bymedication induced
Othello syndrome (13.7%) and vascular dementia (8.4%). Lesions
particularly in the right (dorsolateral) frontal lobes were associated
with this syndrome.
Conclusion This study demonstrates that Othello syndrome
occurs most frequently in patients with right frontal lobe dys-
function. It is predominantly related with Lewy Body Disease and
Alzheimer’s disease. Clinicians should keep an “index of suspicion”
regarding dementia when Othello syndrome presents in elderly
persons.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0353
Reward learning and dopamine
release in adults with 22q11DS
E. Van Duin , Z. Kasanova , M. Beck , D. Hernaus ,
I. Myin-Germeys , T. van Amelsvoort ∗
1 Maastricht University, Psychiatry, Maastricht, The Netherlands
2 KU Leuven, Psychiatry, Leuven, Belgium
∗ Corresponding author.
Background 22q11.2 deletion syndrome (22q11DS) is a genetic
disorder caused by a microdeletion on chromosome 22q11.2 and