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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237



To assess the prevalence, demographics, clinical correlates

and course of these euphoric versus irritable pediatric mania.


Systematic review of the available studies assessing the

phenomenology, course and outcome of pediatric mania.


Eighteen studies reported the number of subjects pre-

senting with either irritable or elated mood during mania.

Irritability has been reported to be the most frequent clinical fea-

ture of pediatric mania reaching a sensitivity of 95–100% in several

samples. Only half the studies reviewed reported on number of

episodes or cycling patterns and the described course was mostly

chronic and ultra-rapid whereas the classical episodic presentation

was less common. Few long-term outcome studies have reported

a diagnostic stability of mania from childhood to young adult age.


Severe irritability is the most common presentation

of abnormal mood described in children with bipolar disorder.

Longitudinal studies of samples with irritable versus elated mood

presentation and chronic versus episodic course may help clarify

whether these are factors predicting different long-term course,

treatment-response and outcome of pediatric onset bipolar disor-


Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

e-poster walk: Classification of mental disorders

and cultural psychiatry


Pretreatment predictors of early

response revealed by quantitative

cerebral blood flow in major

depressive disorder

Z. Hou

1 ,

, Z. Wang


, W. Jiang


, Y. Yin


, Y. Yue


, Y. Zhang



Y. Yuan



Zhongda Hospital, Medical School of Southeast University,

Department of Psychosomatics and Psychiatry, Nanjing, China


Zhongda Hospital, Medical School of Southeast University,

Department of Neurology, Nanjing, China

Corresponding author.


The potential pattern of regional cerebral blood flow

(rCBF) in major depressive disorder (MDD) underlies different

response to antidepressants medication remain unclear. This study

aimed to investigate the differences of rCBF between patients with

different treatment response.


Eighty MDD patients [(44 treatment-responsive

depression (RD) and 36 non-responding depression (NRD)] and

42 healthy controls (HC) underwent pulsed arterial spin labeling

(PASL) scans in magnetic resonance imaging and clinical esti-

mates. The exact rCBF values of each groups were obtained via

quantification evaluation.


Compared to NRD, the RD patients showed decreased

rCBF values in frontal sensorimotor network (i.e. left paracentral

lobule, left medial frontal gyrus, right superior frontal gyrus and

right middle frontal gyrus), and further receiver operating curve

(ROC) analyses demonstrated that the altered rCBF in these four

regions exhibited outstanding performance on distinguishing NRD

from RD. The NRD also exhibited reduced rCBF in bilateral cerebel-

lum posterior lobe and right middle occipital gyrus and elevated

rCBF in right postcentral gyrus and right middle frontal gyrus as

compared to HC.


The decreased rCBF in frontal sensorimotor net-

work appeared to be distinct characteristics for NRD, and might

be severed as promising neuroimaging markers to differentiate

depressed patients with weak early response to antidepressant

medication. These findings expand our understanding of neural

substrate underlying the antidepressant efficacy.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Review of Othello syndrome and its

relationship with neurological


P. Michielsen

1 ,

, L . D

e Jonge

2 , S. P


3 , M.




Mental Health Western Northern Brabant, General Adult Psychiatry,

Halsteren, The Netherlands


Mental Health Western Northern Brabant, Department of

Neuropsychiatry and Geriatric Psychiatry, Halsteren, The Netherlands


University of Groningen, University Medical Center Groningen,

Department of Clinical Pharmacy and Pharmacology, Groningen, The



University of Groningen, University Medical Center Groningen,

Department of Old Age Psychiatry, Groningen, The Netherlands

Corresponding author.


Othello syndrome is a psychotic disorder character-

ized by delusion of infidelity or jealousy. It predominantly occurs in

the context of specific psychiatric or neurological disorders. Othello

syndrome is associated with mental changes including excessive

aggression, hostility, and irritability. Patients with Othello syn-

drome misinterpret the behaviour of the spouse or sexual partner

to provide evidence for their false perception.

Objectives and aims

The purpose of this paper is to examine the

phenomenon of Othello syndrome as a result of specific neurolog-

ical diseases.


The study design was a retrospective case series of

patients with Othello syndrome. We searched the electronic

databases PubMed and Embase for review articles and original

research using the search terms ‘Othello syndrome, Morbid Jeal-

ousy, Pathological Jealousy, Delusional Jealousy, Delusions and

Infidelity, Delusions of Jealousy or Infidelity’.


In the present study of 95 case reports, the relation-

ship between Othello syndrome and a neurological pathology was

described. This syndrome was most commonly associated with

neurodegenerative diseases (59%), followed bymedication induced

Othello syndrome (13.7%) and vascular dementia (8.4%). Lesions

particularly in the right (dorsolateral) frontal lobes were associated

with this syndrome.


This study demonstrates that Othello syndrome

occurs most frequently in patients with right frontal lobe dys-

function. It is predominantly related with Lewy Body Disease and

Alzheimer’s disease. Clinicians should keep an “index of suspicion”

regarding dementia when Othello syndrome presents in elderly


Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Reward learning and dopamine

release in adults with 22q11DS

E. Van Duin


, Z. Kasanova


, M. Beck


, D. Hernaus



I. Myin-Germeys


, T. van Amelsvoort

1 ,


Maastricht University, Psychiatry, Maastricht, The Netherlands


KU Leuven, Psychiatry, Leuven, Belgium

Corresponding author.


22q11.2 deletion syndrome (22q11DS) is a genetic

disorder caused by a microdeletion on chromosome 22q11.2 and