European Psychiatry - Volume 41 - April 2017

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S220 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237
EW0336
Paternal smoking during early
developmental period and risk of
offspring’s attention deficit
hyperactivity disorder
H.S. Kim ∗, W.S. Yang , C.H. Lee , Y.R. Bang , J.H. Yoo ,
S.H. Kim , J.H. Park
1 Dong-A University Hospital, Psychiatry, Busan, Republic of Korea
2 Seoul National University Bundang Hospital, Psychiatry, Seongnam,
Republic of Korea
3 Dong-A University Hospital, Pediatrics, Busan, Republic of Korea
∗ Corresponding author.
Introduction Although prenatal maternal smoking is an estab-
lished risk factor for offspring’s attention deficit hyperactivity
disorder (ADHD), the studies of association between paternal
smoking and childhood ADHD have produced inconsistent results.
Objective The objective of the present study was to determine
whether paternal smoking during early developmental period is
associated with an increased risk of offspring’s ADHD.
Methods We conducted hospital-based case-control study with
107 medically diagnosed ADHD cases and 205 controls (aged
6–12 years). The diagnoses of ADHD were assessed with DSM-
IV based semi-structured diagnostic interviews. Paternal smoking
behavior was assessedwith spouse-report questionnaire. The asso-
ciation between exposure to paternal smoking and ADHD were
analyzed using multivariate logistic regression analysis. The pri-
mary outcome of interest was an odds ratio (ORs) reflecting the
risk of offspring’s ADHD incidence associatedwith father’s smoking
during the index pregnancy, up to one year after birth, and current
smoking status. Control variables in our regressionmodel were age,
sex, financial status, parents’ education levels, lowbirthweight, and
premature birth.
Results Our final regression model revealed that paternal smok-
ing during pregnancy (OR = 1.68, 95% CI = 1.03–2.76) and up to one
year after birth (OR = 1.69, 95% CI = 1.04–2.77) were significantly
related to their offspring’s ADHD.
Conclusions The current results suggest that exposure to paternal
smoking during the fetal and newborn period is associated with
increased risk of ADHD. This study warrants public health policies
to reduce children’s exposure to secondhand smoke and their risk
of ADHD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0337
Adversity, parental mental illness, and
risk of depression in youth
V. Patterson ∗, L. Mackenzie , A. Zwicker , V. Drobinin ,
J. Cumby , S. Abidi , A. Bagnell , L. Propper , M. Alda , R. Uher
1 Nova Scotia Health Authority, Psychiatry Research, Halifax, Canada
2 Dalhousie University, Psychology, Halifax, Canada
3 Dalhousie University, Pathology, Halifax, Canada
4 Dalhousie University, Medical Neuroscience, Halifax, Canada
5 IWK Hospital, Psychiatry, Halifax, Canada
6 Nova Scotia Health Authority, Psychiatry, Halifax, Canada
∗ Corresponding author.
Background The association between parental severe mental ill-
ness (SMI) and depression in offspring may be due to genetic
liability or adverse environments. We investigated the effect of
parental SMI, SES, and adversity on depression in a sample of youth
enriched for familial risk of mental illness.
Method We assessed 217 youth (mean age 11.95, SD 4.14, range
6–24), including 167 (77%) offspring of parents with SMI. We mea-
sured exposure to childhood maltreatment and bullying with the
Juvenile Victimization Questionnaire (JVQ) and Childhood Experi-
ences of Care and Abuse (CECA) interview.
Results In total, 13.36% participants reported significant bully-
ing and 40.76% had a history of childhood maltreatment. Rates
of bullying and maltreatment were similar in offspring of par-
ents with andwithout SMI. Maltreatment likelihood increasedwith
decreasing socioeconomic status. Exposure to bullying (OR = 3.11,
95%CI 1.08–8.88, P = 0.03) predicted depression in offspring more
strongly than family history of SMI in parents.
Conclusions Adversity, such as maltreatment and bullying, has a
stronger impact on the risk of developing depression than family
history of mental illness in parents. These adverse experiences are
associated with socioeconomic status rather than parental mental
illness.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0338
Paradigm shift in the educational
system of adolescents with disabilities
S. Paulino ∗, C. Almeida , M. Croca , N. Santos
Hospital Santa Maria, Psychiatry Service, Lisbon, Portugal
∗ Corresponding author.
Introduction In the last years, there has been a paradigm shift
in the educational system of young people with disabilities. Regu-
lar schools associated with specific support plans have become the
destination of choice for these adolescents, instead of schools with
special education. This integrated teaching seeks to reduce stigma
and to promote tolerance but frequently these students become
easy targets of psychological and physical violence or discrimina-
tion.
Objective To evaluate the integration of adolescents with disabil-
ities in mainstream education compared to special teaching.
Methods Analysis of 32 patients with disabilities from the ado-
lescence consultation of the psychiatry service of hospital de Santa
Maria, between January 2015 and September 2016.
Results About 30% of the adolescents with disabilities who attend
regular schools with special support complains of poor adjustment
associated with some kind of mistreatment by peers.
Conclusion Violence among students in school is a current prob-
lem very difficult to fight. Young people with disabilities often
find themselves in a significant minority presenting less efficient
defense mechanisms. If unprotected, they may easily develop
school phobia or refusal. These situations must be identified and
avoided to prevent the associated suffering.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0339
Association between irritability and
depressive symptoms in children and
adolescents
M. Busto-garrido Gutierrez-castillo . Navas-gonzalez
M. Gutierrez-bedmar Gutierrez-casares
M.T. Martin-lunar odriguez-rosado . Pena-andreu ∗
1 Hospital Regional de Malaga, Psychiatry, Malaga, Spain
2 Hospital Virgen de la Victoria, Psychiatry, Malaga, Spain
3 Universidad de Malaga. School of Medicine, Public Health and
Psychiatry, Málaga, Spain
4 Complejo hospitalario universitario de Badajoz, Psychiatry, Badajoz,
Spain
∗ Corresponding author.