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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237



Irritability is themost frequently reported symptom

in child and adolescent depression. The association of both has been

linked with high rates of chronicity, comorbility and impairment.


To study the association between irritability and

depressive symptoms in children and adolescents.


We have studied 857 participants recruited from the

only child and adolescent mental health clinic in a catchment area

of 122,968 people under 18 (2004–2010). A sample of 857 partic-

ipants (112 controls and 745 patients) was included to carry out

a cross-sectional study. Irritability was measured by a Visual Ana-

log Scale (VAS irritability)–scored from 0 to 10–, and depressive

symptoms by the Children’s Depression Inventory (CDI). The par-

ticipantswere categorized into controls and patients, and according

to their irritability (

4 [I], 5 [II] and

6 [III]). The mean of CDI score

was calculated for each of the groups, adjusted by sex and age, and

analyzed by ANCOVA.


The following means were obtained from the controls:

13,71 (group I), 9,82 (group II) and 17,45 (group III). Regarding

to the patients: 13,92 (group I), 11,54 (group II) and 15,64 (group

III). A quadratic association (


< 0.0015) was found between VAS

irritability score and CDI score.


There is not a linear association between irritability

and depressive symptoms in children and adolescent. High rates

of depressive symptoms were associated both with high and low

rates of irritability. Several questions remain unexplained about

the status of irritability in psychiatry, as Stringaris group has been

pointed out.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Negative psychotic symptoms in

22q11.2 deletion and their association

with neuropsychological profile

M. Pontillo

1 ,

, A . L


2 , M.


1 , D.


1 , G.


2 ,

S. Vicari



Children Hospital Bambino Gesù, Neuroscience and

Neurorehabilitation, Rome, Italy


Thelethon Kids Institute, Thelethon Kids Institute, Perth, Australia

Corresponding author.

22q11.2 deletion syndrome (22q11.2 DS) is associated with a

markedly elevated risk for schizophrenia spectrum disorders. The

role of negative symptoms in the pathogenesis of schizophrenia in

this population and their link to role, social and cognitive func-

tioning is still unclear. Aims of this study were investigate the

association between negative symptoms, social and role function-

ing and neurocognitive performance in the sample of individuals

with 22q11.2DS and compare them to healthy controls. The study

was conducted on a sample of 60 individuals with 22q11.2DS

(mean age = 14.8; SD = 4.8) and 56 healthy control (HC) partici-

pants (mean age = 13.8; SD = 5.4). Individuals with 22q11DS and

high level of negative symptoms showed significantly higher level

of impairment in several neurocognitive domain (i.e. visuospatial

abilities, verbal response inhibition) compared with individuals

with 22q11DS and low level of negative symptoms and healthy

controls. They showed also lower global functioning, specifically

role functioning and not social functioning. Negative symptoms

are frequent in 22q11.2DS and are associated with specific cog-

nitive deficit and low role functioning. These results suggest that

negative symptoms should be considered an important target in

the assessment of risk of conversion to full-blown psychosis and in

planning of psychological interventions for this population.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Correlations between the parents’

ADHD score and the child’s ADOS score

in parents of children with comorbid

ADHD–autism spectrum disorder

F. Rad

1 ,

, L. Kobylinska


, I. Mihailescu


, A. Buica


, I. Dobrescu



University of Medicine and Pharmacy Carol Davila, Child and

Adolescent Psychiatry, Bucharest, Romania


Prof. Dr. Al. Obregia Psychiatry Hospital, Child and Adolescent

Psychiatry, Bucharest, Romania

Corresponding author.

From assortative mating theory to genetic background, several

ethipathogenic hypotheses in ASD deal with the traits of parents.


several ethipathogenic hypotheses in ASD deal with

the traits of parents. The objectives of our study were to measure

the ADHD and autism spectrum disorder quotients in parents of

children diagnosed with ASD comorbid with ADHD and to corre-

late the measurements for the tests in parents with those in their

children. The specific aim was to identify whether any significant

correlations exist.


Fifty-two pairs of parents of children with autism spec-

trum disorders and ADHD were included in this study, based on

informed consent and the ethical committee’s approval. The child’s

diagnosis was established by a specialist in child and adolescent

psychiatry, based on the child’s clinical symptoms and on spe-

cific diagnostic scales, such as the ADOS and ADHD-rating scale.

The parents completed an Autism Spectrum Quotient Scale (ASQS)

and an adult ADHD scale. The data were analyzed using SPSS 22.0

and Excel. The correlations were verified using Spearman’s non-

parametric correlation test.


There was a strong correlation between the parents’

ADHD scores (


= 0.5,


< 0.001), and a reverse medium correla-

tion between the mother’s ADHD score and the child’s ADOS score



= –0.32,


= 0.02). The father’s ASQS and ADHD scores correlated

between each other (


= 0.31,


= 0.02). There were no correlations

between the parents’ and the child’s ADHD score, nor between the

child’s ADOS score and the parents’ ASQS scores.


Our results suggest that ADHD symptoms in parents

of children with autism spectrum disorders comorbid with ADHD

might be predictors for the child’s prognosis.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


The co-occurrence of non-suicidal

self-injury and attempted suicide

among adolescents hospitalized in

clinic for mental disorders “Dr Laza


D. Randjelovic

1 ,

, S. Mihajlovic


, D. Randjelovic



D. Nikolic Dimitrijevic



Clinic for mental disorder “Dr Laza Lazarevic”, Clinical department

for older adolescents, Belgrade, Serbia


Clinic for mental disorders “Dr Laza Lazarevic”, Clinical department

for psychotic disorders, Belgrade, Serbia


Medicom policlinic for child and adults, Psychiatry, Belgrade, Serbia


Clinic for mental disorders “Dr Laza Lazarevic”, Daily hospital,

Belgrade, Serbia

Corresponding author.


The phenomenon of non-suicidal self-injury (NSSI)

as an act of deliberate destruction of body tissue without suicidal

intent is common in adolescence. NSSI and suicide attempts (SA),

although distinct behaviors differing in intent, form and function,

often co-occur in the same individual.