European Psychiatry - Volume 41 - April 2017

225 / 916

25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237 S221
Introduction Irritability is themost frequently reported symptom
in child and adolescent depression. The association of both has been
linked with high rates of chronicity, comorbility and impairment.
Objectives To study the association between irritability and
depressive symptoms in children and adolescents.
Methods We have studied 857 participants recruited from the
only child and adolescent mental health clinic in a catchment area
of 122,968 people under 18 (2004–2010). A sample of 857 partic-
ipants (112 controls and 745 patients) was included to carry out
a cross-sectional study. Irritability was measured by a Visual Ana-
log Scale (VAS irritability)–scored from 0 to 10–, and depressive
symptoms by the Children’s Depression Inventory (CDI). The par-
ticipantswere categorized into controls and patients, and according
to their irritability (≤ 4 [I], 5 [II] and ≥ 6 [III]). The mean of CDI score
was calculated for each of the groups, adjusted by sex and age, and
analyzed by ANCOVA.
Results The following means were obtained from the controls:
13,71 (group I), 9,82 (group II) and 17,45 (group III). Regarding
to the patients: 13,92 (group I), 11,54 (group II) and 15,64 (group
III). A quadratic association (P < 0.0015) was found between VAS
irritability score and CDI score.
Conclusions There is not a linear association between irritability
and depressive symptoms in children and adolescent. High rates
of depressive symptoms were associated both with high and low
rates of irritability. Several questions remain unexplained about
the status of irritability in psychiatry, as Stringaris group has been
pointed out.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0340
Negative psychotic symptoms in
22q11.2 deletion and their association
with neuropsychological profile
M. Pontillo ∗ in Armando Menghini Alvares
S. Vicari
1 Children Hospital Bambino Gesù, Neuroscience and
Neurorehabilitation, Rome, Italy
2 Thelethon Kids Institute, Thelethon Kids Institute, Perth, Australia
∗ Corresponding author.
22q11.2 deletion syndrome (22q11.2 DS) is associated with a
markedly elevated risk for schizophrenia spectrum disorders. The
role of negative symptoms in the pathogenesis of schizophrenia in
this population and their link to role, social and cognitive func-
tioning is still unclear. Aims of this study were investigate the
association between negative symptoms, social and role function-
ing and neurocognitive performance in the sample of individuals
with 22q11.2DS and compare them to healthy controls. The study
was conducted on a sample of 60 individuals with 22q11.2DS
(mean age = 14.8; SD = 4.8) and 56 healthy control (HC) partici-
pants (mean age = 13.8; SD = 5.4). Individuals with 22q11DS and
high level of negative symptoms showed significantly higher level
of impairment in several neurocognitive domain (i.e. visuospatial
abilities, verbal response inhibition) compared with individuals
with 22q11DS and low level of negative symptoms and healthy
controls. They showed also lower global functioning, specifically
role functioning and not social functioning. Negative symptoms
are frequent in 22q11.2DS and are associated with specific cog-
nitive deficit and low role functioning. These results suggest that
negative symptoms should be considered an important target in
the assessment of risk of conversion to full-blown psychosis and in
planning of psychological interventions for this population.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0341
Correlations between the parents’
ADHD score and the child’s ADOS score
in parents of children with comorbid
ADHD–autism spectrum disorder
F. Rad ∗, L. Kobylinska , I. Mihailescu , A. Buica , I. Dobrescu
1 University of Medicine and Pharmacy Carol Davila, Child and
Adolescent Psychiatry, Bucharest, Romania
2 Prof. Dr. Al. Obregia Psychiatry Hospital, Child and Adolescent
Psychiatry, Bucharest, Romania
∗ Corresponding author.
From assortative mating theory to genetic background, several
ethipathogenic hypotheses in ASD deal with the traits of parents.
Background several ethipathogenic hypotheses in ASD deal with
the traits of parents. The objectives of our study were to measure
the ADHD and autism spectrum disorder quotients in parents of
children diagnosed with ASD comorbid with ADHD and to corre-
late the measurements for the tests in parents with those in their
children. The specific aim was to identify whether any significant
correlations exist.
Method Fifty-two pairs of parents of children with autism spec-
trum disorders and ADHD were included in this study, based on
informed consent and the ethical committee’s approval. The child’s
diagnosis was established by a specialist in child and adolescent
psychiatry, based on the child’s clinical symptoms and on spe-
cific diagnostic scales, such as the ADOS and ADHD-rating scale.
The parents completed an Autism Spectrum Quotient Scale (ASQS)
and an adult ADHD scale. The data were analyzed using SPSS 22.0
and Excel. The correlations were verified using Spearman’s non-
parametric correlation test.
Results There was a strong correlation between the parents’
ADHD scores (r= 0.5, P < 0.001), and a reverse medium correla-
tion between the mother’s ADHD score and the child’s ADOS score
(r= –0.32, P= 0.02). The father’s ASQS and ADHD scores correlated
between each other (r = 0.31, P = 0.02). There were no correlations
between the parents’ and the child’s ADHD score, nor between the
child’s ADOS score and the parents’ ASQS scores.
Conclusion Our results suggest that ADHD symptoms in parents
of children with autism spectrum disorders comorbid with ADHD
might be predictors for the child’s prognosis.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0342
The co-occurrence of non-suicidal
self-injury and attempted suicide
among adolescents hospitalized in
clinic for mental disorders “Dr Laza
Lazarevic”
D. Randjelovic ∗, S. Mihajlovic , D. Randjelovic ,
D. Nikolic Dimitrijevic
1 Clinic for mental disorder “Dr Laza Lazarevic”, Clinical department
for older adolescents, Belgrade, Serbia
2 Clinic for mental disorders “Dr Laza Lazarevic”, Clinical department
for psychotic disorders, Belgrade, Serbia
3 Medicom policlinic for child and adults, Psychiatry, Belgrade, Serbia
4 Clinic for mental disorders “Dr Laza Lazarevic”, Daily hospital,
Belgrade, Serbia
∗ Corresponding author.
Introduction The phenomenon of non-suicidal self-injury (NSSI)
as an act of deliberate destruction of body tissue without suicidal
intent is common in adolescence. NSSI and suicide attempts (SA),
although distinct behaviors differing in intent, form and function,
often co-occur in the same individual.