European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S238–S302 S289
EW0537
Hypnotic drugs in hospital. Evaluation
of their use: From prescription to
administration
S. Wise ∗, S. Lukat , M. Dalle Pécal , C. Diviné , C. Henry
1 Hôpital Albert-Chenevier, hôpitaux universitaires Henri-Mondor,
AP–HP, service pharmacie, Créteil, France
2 Hôpital Albert-Chenevier, hôpitaux universitaires Henri-Mondor,
pôle de psychiatrie universitaire, centres experts, Créteil, France
∗ Corresponding author.
In 2015, a French agency, Haute Autorité de santé (HAS), pub-
lished recommendations for the use of hypnotic drugs. We
evaluated the compliance with good practice in prescription and
administration studying 3 hypnotics (lormetazepam, zolpidem,
zopiclone) referenced in our establishment (psychiatry, rehabilita-
tion, recuperative and long-term care) and melatonin (immediate
release hospital preparation). Prescriptions were analyzed on a
given day (dosage, length of treatment, prescription modalities).
Night nursing practices were collected. Amongst 423 hospital-
ized patients, 105 had a hypnotic monotherapy, 3 an association
melatonin/zopiclone and 6 a melatonin monotherapy. The most
prescribed molecule was zopiclone (79%). Prevalence of hypnotic
prescription was 25.5%. 17.6% of these prescriptions were for less
than 28 days, 82.5% were at maximum dosage, 46.3% were in sys-
tematic mode and 53.7% in conditional mode. Amongst the 22
patients over 65 years old, only 8 received half hypnotic dose.
Concerning the 9 prescriptions of melatonin, dosage varied from
3 to 9mg, 1 was in conditional and only 1 specified terms of use.
All 15 nurses met, adapt administration to the patient’s bedtime.
Five nurses have already woken up patients to give them hyp-
notics. The prevalence of patients with hypnotics is higher than
the general French population (6.4%). HAS recommendations are
not all followed: duration of prescription greater then 28 days, few
dosage adaptations. Nurses generally respect hypnotic administra-
tion rules. Melatonin is not often prescribed and has no prescription
or administration recommendations. Our results confirm the need
to spread hypnotic andmelatonin recommendations in health facil-
ities. Hospital pharmacists can relay such recommendations.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0538
What do Tunisian general
practitioners know about insomnia?
K. Yaich ∗, M. Maalej Bouali , N. Charfi , W. Sellami , N. Zouari ,
L. Zouari , J. Ben Thebet , M. Maalej
Hedi Chaker University Hospital, Psychiatry C department, Sfax,
Tunisia
∗ Corresponding author.
Introduction Insomnia is the most prevalent sleep disorders and
affects 10% of adults worldwide. It has major social and economic
consequences. The aim of our study was to evaluate the knowledge
of Tunisian general practitioners (GPs) about insomnia.
Methods A cross-sectional survey was carried out during the
month of May 2016. Among the 193 GPs randomly selected from
different areas of Sfax, in Tunisia, 127 participated to the study.
The latter filled a questionnaire including items related to socio-
demographic data and clinical features of insomnia.
Results Among our participants, 58.3% (n = 74) were men and
41.7% (n = 53) women. The average agewas 47.91 ± 10.1 years. They
have been working for 17.36 ± 10.7 years on average. Seventy-six
of GPs had an individual training and a training by attending con-
ferences or by continuous medical education. Most participants
(80.3%) thought that they had some lacuna in the management
of insomnia. Specific recommendations for the management and
treatment of insomnia were known by 7.2% of the GPs. As for the-
oretical knowledge about insomnia, 74.8% of participants (n = 95)
had a high score of correct answers. The latter was correlated to
age (P = 0.013) and to the male gender (P = 0.008). However, it was
neither correlated to the seniority of the GPs (P = 0.051) nor to the
knowledge of specific recommendations for the management of
insomnia (P = 0.11).
Conclusion Our results showed that the GPs had a rather good
theoretical knowledge about insomnia. Yet, an improvement of the
continuous medical education and a better knowledge of specific
recommendations for the management of insomnia are needed.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0539
The management of insomnia by
Tunisian general practitioners
K. Yaich∗, M. Maalej Bouali , N. Charfi , W. Sellami , Z. Nasr ,
L. Zouari , J. Ben Thebet , M. Maalej
Hedi Chaker University Hospital, Psychiatry C department, Sfax,
Tunisia
∗ Corresponding author.
Introduction Sleep disorders are common in clinical practice.
However, they are relatively poorly understood by doctors. The
aim of our study was to describe the management of insomnia by
general practitioners (GPs).
Methods A cross-sectional survey was carried out during the
month of Mai 2016. Among the 193 GPs randomly selected from
different areas of Sfax, in Tunisia, 127 completed a questionnaire
about the management of insomnia.
Results Among our participants, 46.5% stated that they often
discuss the quality of sleep with their patients even when it is
not their chief complaint. Forty-three percent reported that they
are often consulted by insomniac patients. Twelve percent of GPs
declared they know the “sleep diary”. Homeopathic treatment was
the most prescribed first line medication (45.3%). Sleep hygiene
measures were commonly recommended by 82.7% of the GPs.
Relaxation therapy was known by 46.7% of the GPs and used by
26.7%. Sleep-restriction therapy was known and used by respec-
tively 15.8% and 9.2% of participants. Discussing the quality of sleep
with patients was correlated to: the frequency of solicitation for
insomnia (P = 0.00), the knowledge of sleep diary (P = 0.031), and
the recommendation of sleep hygiene measures (P = 0.032).
Conclusion Continuous medical education, especially concern-
ing non-pharmacological treatment measures, could drastically
improve the management of insomnia by Tunisian GPs.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0540
Emotion processing abnormalities in
eating disorders: An fMRI pilot study
P. Zemánková ∗ Gajdoˇs aˇspárek Bareˇs
1 Masaryk University, Faculty of Medicine, Department of Psychiatry,
Brno, Czech Republic
2 Central European Institute of Technology, Behavioural and Social
Neuroscience, Brno, Czech Republic
3 Central European Institute of Technology, Multimodal and
Functional Imaging Laboratory, Brno, Czech Republic
4 Masaryk University, Faculty of Medicine, First Department of
Neurology, Brno, Czech Republic
∗ Corresponding author.
Introduction Abnormalities in emotional functioning is one of the
key features of eating disorders (ED), such as anorexia nervosa (AN)