European Psychiatry - Volume 41 - April 2017

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S288 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S238–S302
Introduction Electric indoor lighting can disturb sleep and
increase depressive symptoms; both common complaints in psy-
chiatric inpatients.
Aims To improve quality of sleep in patients using an indoor hos-
pital lighting environment simulating nature in intensity, color, and
circadian timing.
Methods Investigator-blinded parallel group randomized con-
trolled effectiveness trial supplied with qualitative interviews in
an inpatient psychiatric ward with fully automatic and adjustable
lighting. Admitted patients received a room with a naturalistic
lighting environment (intervention group) or lighting as usual (con-
trol group). The primary outcome was the Pittsburg Sleep Quality
Index and secondary outcomes included the Major Depression
Inventory and WHO-five Well- Being Index.
Results In this ongoing trial, we included 28 patients (16 treated
and 12 controls). Patients in the intervention group reported higher
subjective sleep quality and sleep efficiency, lower use of sleep
medication (mean difference, 4.68mg; 95% CI, 0.54; 53.5), fewer
depressive symptoms (mean difference, 5; 95% CI,–2; 13), but lower
well-being (difference,–4 percentage points; 95% CI,–20; 16), com-
pared with the control group. At discharge, fewer patients in the
intervention group had experienced use of involuntary treatment.
Qualitative data indicated no side effects apart from issues in per-
forming indoor leisure activities in dim light.
Conclusions A naturalistic lighting environment was safe and
improved sleep and mood in our small patient sample. The trial
integrated well with routine clinical care and our sample reflected
the heterogeneity of the target population (Funded by Region
Midtjylland and others; Clinicaltrials.gov number, NCT02653040)
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0535
Psychological and
psychophysiological mechanisms of
mental stress reaction in patients
with ‘hypertension at work’, as
compared with ‘classical’ version of
essential hypertension
E. Pervichko ∗, Y. Zinchenko , O. Ostroumova
1 Lomonosov Moscow State University, Faculty of Psychology,
Moscow, Russia
2 Moscow State University of Medicine and Dentistry, Faculty of
General Medicine, Moscow, Russia
∗ Corresponding author.
Introduction ‘Hypertension at work’ today is found one of the
most frequent forms of stress-induced hypertension.
Objectives To inquire into the specifics of psychological and
psychophysiological mechanisms of stress reaction in patients
with ‘hypertension at work’, as compared with ‘classical’ essential
hypertension (EH).
Materials and methods The study developed simulation of emo-
tional stress with the aspiration level (AL) modeling. The level of
state anxiety (SA), BP values, urine catecholamine levels and lev-
els of renin and angiotonin I in blood plasma were taken before
and after the experiment. Eighty-five patients with ‘hypertension
at work’ (mean age was 45.9 ± 2.8) and 85 patients with ‘classical’
EH (mean age was 47.4 ±4.5 years) took part in the study.
Results Rates of ‘hypertension at work’ patients, when com-
pared with second group patients, revealed a significant increase
(Р < 0.001) of systolic BP in response to stress loads (on average,
for 16.1 ± 1.9mmHg and 4.1 ± 0.7mmHg, respectively). Initially
‘hypertension at work’ patients had significantly lower levels of cat-
echolamines, than the second group, while the levels of renin and
angiotensin Iwere comparable. During the experiment, the patients
in the first group showed a significant decrease in all parameters.
After the experiment, the patients with ‘HTN at work’ did not show
increase of SA, but revealed more frequent inadequacy (69.4%) and
instability (56.5%) on the AL. Patients with ‘classical’ EHmore often
demonstrate adequate AL and lower growth of BP after the exper-
iment.
Conclusions Patients with ‘hypertension at work’ are more prone
to repress their emotions. They reveal physiological features of
chronic stress and psychophysiological exhaustion, if compared
with second group patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0536
Longitudinal changes in sleep
disturbances, mental toughness, and
physical activity in patients with
multiple sclerosis
D. Sadeghi Bahmani ∗, L. Esmaeili , M. Gerber , S. Lemola ,
P.J. Clough , E. Holsboer-Trachsler , S. Brand
1 University of Basel Psychiatric Hospital, Center for Affective, Stress
and Sleep Disorders ZASS, Basel, Switzerland
2 University of Isfahan, Department of Psychology, Educational &
Psychology Faculty, Isfahan, Iran
3 University of Basel, Department of Sport, Exercise and Health, Sport
Science Section, Basel, Switzerland
4 University of Warwick, Department of Psychology, Coventry, United
Kingdom
5 Manchester Metropolitan University, Department of Psychology,
Manchester, United Kingdom
∗ Corresponding author.
Background Multiple sclerosis (MS) is a chronic progressive
autoimmune disease. Fatigue, depression and cognitive impair-
ments are the most common symptoms of patients with MS.
Whereas there is extant research on fatigue, depression, and cogni-
tive impairment of patients with MS during the clinical course, no
research focused on the long term changes of psychological func-
tioning, sleep problems, and physical activity on these patients. The
aims of the present study were therefore to examine changes in
physical activity, sleep disturbances, and mental toughness over a
1.5-year period of time in people with multiple sclerosis after the
onset their MS.
Methods A total of 18 patients with diagnosed MS (mean age:
M = 33.61 years) took part in this study. They completed a booklet
of questionnaires covering socio-demographic data, mental tough-
ness, sleep disturbances, and physical activity, at the onset of
disease and 1.5 years later.
Results In total, 1.5 years after the onset of MS, patients had lower
levels of vigorous physical activity, but not statistically significant
change in moderate physical activity. Patients with sleep distur-
bances at the onset of disease had statistically significant sleep
disturbances also 1.5 years later.
Conclusions Compared to the onset of disease, 1.5 years later,
patients with MS reported similar mental toughness traits, sleep
disturbances and levels of moderate physical activity. The pattern
of results of the present pilot study suggests that the onset of MS is
not an obstacle for doing moderate physical activity. Based on the
result of this study, sleep disturbances remains stable by time.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.