European Psychiatry - Volume 41 - April 2017

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S346 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S303–S364
EW0700
Altered functional connectivity in
default mode network in Internet
gaming disorder with childhood
ADHD
Y.C. Jung ∗, K. Namkoong
Yonsei university, psychiatry, Seoul, Republic of Korea
∗ Corresponding author.
Objective Internet gaming disorder (IGD) is a type of behavioral
addiction characterized by abnormal executive control, leading to
loss of control over excessive gaming. Attention deficit and hyper-
activity disorder (ADHD) is one of the most common comorbid
disorders in IGD, involving delayed development of the execu-
tive control system, which could predispose individuals to gaming
addiction. We investigated the influence of childhood ADHD on
neural network features of IGD.
Methods Resting-state functional magnetic resonance imaging
analysis was performed on 44 young, male IGD subjects with
and without childhood ADHD and 19 age-matched, healthy male
controls. Posterior cingulate cortex (PCC)-seeded connectivity was
evaluated to assess abnormalities in default mode network (DMN)
connectivity, which is associated with deficits in executive control.
Results IGD subjects without childhood ADHD showed expanded
functional connectivity (FC) between DMN-related regions (PCC,
medial prefrontal cortex, thalamus) compared with controls. These
subjects also exhibited expanded FC between the PCC and brain
regions implicated in salience processing (anterior insula, orbito-
frontal cortex) compared with IGD subjects with childhood ADHD.
IGD subjects with childhood ADHD showed expanded FC between
the PCC and cerebellum (crus II), a region involved in executive
control. The strength of connectivity between the PCC and cere-
bellum (crus II) was positively correlated with self-reporting scales
reflecting impulsiveness.
Conclusion Individuals with IGD showed altered PCC-based FC,
the characteristics of which might be dependent upon history of
childhood ADHD. Our findings suggest that altered neural networks
for executive control in ADHD would be a predisposition for deve-
loping IGD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0701
A new model as an early life
manipulation: Fake mother
M. Kucukkarapinar ∗, A. Dönmez , S. Candansayar ,
A. Bozkurt , E. Akc¸ ay
1 Mus¸ government hospital, department of psychiatry, Mus¸ , Turkey
2 Üsküdar university, department of psychology, Istanbul, Turkey
3 Department of psychiatry, Ankara, Turkey
4 Gazi university, faculty of medicine, department of psychiatry,
Ankara, Turkey
5 Ankara university, faculty of medicine, child and adolescent
psychiatry, Ankara, Turkey
6 Neurology, Ankara, Turkey
∗ Corresponding author.
Introduction Early life stressful events cause long-term neural
changes that are associated with psychiatric disorders.
Objective Early lifemanipulations focus on commonly the impact
of remaining separate from the mother in a specific period of time.
The maternal odor is required for pups to approach the mother for
nursing. What happens when there is amother that smell like a real
mother but does not take care her own pups?
Aim To investigate the fake mother effects on adult rat’s beha-
vioral changes, NMDR2B protein level changes in prefrontal cortex
and hippocampus.
Methods Wistar rats were used. Fake mother (n:13), early hand-
ling (n:12), maternal separation (n:14) and control (n:12) were
the study groups. A fake mother is an object that smells like a
real dam. When the real mother is separated from own pups fake
mother stays with the pups for an hour. Manipulations were made
during the postnatal first 14 days. Behavioral tests (social interac-
tion test, elevated plus maze, novel object recognition test) were
made between postnatal 62 and 78 days. NMDAR2B protein levels
in prefrontal cortex and hippocampus were evaluated by using
ELISA at postnatal 78 days.
Results In social interaction test, fake mother group exhibi-
ted less social behavior and more aggressive behavior than the
other groups. Their long-term memory functions were the lowest.
NMDAR2B protein levels in the hippocampus increased in rats that
exposed to early stressful life events.
Conclusion These results support that being raised by fake
mother increases aggressive behavior and decrease social behavior
in adulthood.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0702
Neural correlates of behavioral
inhibition in healthy people and in
patients with borderline personality
disorder and ADHD
P. Linhartová ∗, M. Kuhn , A. Damborská , M. Lamoˇs ,
M. Mikl , R. Barteˇcek , P. Theiner , T. Kaˇspárek , M. Bareˇs
1 Masaryk university and university hospital, department of
psychiatry, BRNO, Czech Republic
2 Masaryk University, central European institute of technology
CEITEC, BRNO, Czech Republic
∗ Corresponding author.
Introduction Deficits in behavioral inhibition leading to impul-
sivity occur frequently in many otherwise different psychiatric
diseases, mainly ADHD and borderline personality disorder (BPD).
However, the research is complicated by using of different tests
and their parameters. Further, the role of frontoparietal network in
behavioral inhibition has been questioned recently.
Objectives The aims of our studies were:
– to present the influence of differences in inhibition tasks parame-
ters;
– to describe neural correlates of behavioral inhibition in healthy
people;
– to compare them with BPD and ADHD patients.
Methods We implemented two different variants of Go/NoGo
Task, one designed for behavioral research and the second for
neuroimaging. Thirty healthy participants (37% of women, age
range 15 to 33 years) underwent behavioral and fMRI measu-
rement. Further, groups of patients with BPD, ADHD and their
healthy controls underwent the Go/NoGo Task under both fMRI and
EEG.
Results The results show differences in behavioral performance
based on different task parameters. The fMRI results in healthy
people show specific activation patterns within the frontoparietal
network associated with inhibition trials (mainly inferior frontal
gyrus, insula, cingulate gyrus, SMA, inferior parietal lobule). Fur-
ther, we present differences between patients with BPD, ADHD and
controls in BOLD signal and ERPs.
Conclusions Go/NoGo Task design substantially influences the
subjects’ behavioral performance. Our results with methodo-
logically upgraded Go/NoGo Task design provide support for
the inhibition frontoparietal brain network and its different
activations in BPD and ADHD patients. The research was sup-
ported by Ministry of Health of the Czech Republic, grant nr.
15-30062A.