European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S303–S364 S345
Results Apathetic depressed patients were significantly less
anxious and less anhedonic. Apathetic perfused better than non-
apathetic in the inferior frontal gyrus (P = 0.022). We found a
significant positive relationship between apathy and perfusion of
the left frontal inferior gyrus (P = 0.05, r= 0.21). State-anxiety was
positively correlated with perfusion of the cingulate cortex, the
insula and the left amygdala. Anhedonia was positively correla-
ted with the perfusion of the ventromedial prefrontal cortex, the
cingulate cortex and the insula.
Conclusions We have shown that the clinical and perfusional pro-
files of apathetic depressed and non-apathetic differ. This study
suggests the existence of two distinct neurobiological networks for
depressed patients; one involving motivational networks for apa-
thetic patients, and another one involving emotional networks for
more anhedonic patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0698
Brain anatomy of symptom
stratification in schizophrenia:
A voxel based morphometry study
G. Delvecchio ∗, A. Lorandi , C. Perilini , M. Barillari ,
M. Ruggeri , A.C. Altamura , M. Bellani , P. Brambilla
1 IRCCS “E. Medea”, scientific institute, San Vito al Tagliamento, Italy
2 Azienda Ospedaliera universitaria integrata Verona, section of
psychiatry, Verona, Italy
3 Biomedicine and movement sciences, section of clinical psychology,
university of Verona, department of neurosciences, Verona, Italy
4 Azienda ospedaliera universitaria integrata Verona, section of
radiology, Verona, Italy
5 Biomedicine and movement sciences, section of psychiatry,
university of Verona, department of neurosciences, Verona, Italy
6 Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,
university of Milan, department of neurosciences and mental health,
Milan, Italy
∗ Corresponding author.
Introduction Although some magnetic resonance imaging (MRI)
studies have investigated the existence of a relationship between
clinical severity and neuroanatomical alterations in patients with
schizophrenia (SCZ), the biological signature associatedwith illness
severity in schizophrenia is still uncertain.
Objectives This study aims to investigate structural brain abnor-
malities in SCZ with particular regards to the identification of
potential deficits associated to the severity of illness.
Methods 1.5 T MRI data were acquired for 61 subjects with SCZ
and 59 matched healthy controls (HC). The patient group was divi-
ded in two subgroups based on clinical severity, one composed by
34mild-to-moderately ill patients and the other one by 27 severely
ill patients, and compared with matched HC.
Results The whole group of patients with SCZ had signifi-
cantly reduced gray matter (GM) volumes in left inferior and
middle temporal gyrus compared to HC (P< 0.05, pFWE corrected).
Furthermore, compared to HC, patients with mild-to-moderate
illness showed decreased GM volumes in inferior temporal
gyrus (P < 0.05, pFWE corrected) whereas those with severe ill-
ness had reduced right cerebellum ( P < 0.05, cFWE corrected).
No differences were observed between the two subgroups of
patients.
Conclusions Our results showed significant GM volume reduc-
tions in left inferior and middle temporal gyrus in patients
with SCZ compared to matched HC, confirming the role of this
region in the pathophysiology of SCZ. Furthermore, we identi-
fied specific cerebellar gray matter volume reductions in patients
with severe illness, which may contribute to stratify patients
with SCZ according to their clinical phenotype expression, ulti-
mately helping in guiding targeted therapeutic/rehabilitation
interventions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0699
Neural functional correlates of
empathic face processing:
An activation likelihood estimation
(ALE) meta-analysis of fMRI studies
A. Del Casale , D. Janiri ∗, G. Kotzalidis , G. Giuseppin ,
E. Spinazzola , M. Maggiora , C. Rapinesi , S.M. Tamorri ,
M. Aragona , A. Puzella , S. Ferracuti , M. Pompili , G. Sani ,
P. Girardi
1 Sapienza university of Rome, faculty of medicine and psychology,
NESMOS department neurosciences, mental health and sensory
functions, Rome, Italy
2 Crossing dialogues association, Rome, Italy
3 Studio Multiverso, ATC-SITCC, studio multiverso, ATC-SITCC, Rome,
Italy
4 Sapienza university of Rome, department of neurology and
psychiatry, Rome, Italy
∗ Corresponding author.
Introduction Empathy is evolutionary preserved in social orga-
nisms and emotional face processing is one of itsmeasures. Systems
possibly active during empathic processing include perspective-
taking, basic emotional contagion “mirroring” and “theory of mind”
systems.
Objectives fMRI studies help clarifying neural correlates of empa-
thic face processing; ALE meta-analysing fMRI studies allows
identification of brain area activation/deactivationduring empathy.
Aims To identify brain areas most consistently involved in empa-
thy.
Methods We carried ALE meta-analysis of original studies focu-
sing on cerebral activations during empathic face processing tasks
and reporting data on Talairach or MNI space coordinates, conver-
ting the former in the latter. An 11-April-2016 PubMed search,
using as keywords terms like empathy combined with functio-
nal magnetic resonance imaging (fMRI), produced 124 records of
which 23 were finally included (568 participants, 247 males and
321 females; mean age 32.2 years). We followed the PRISMA state-
ment. Whole-brain data were meta-analysed; significance was set
at P = 0.0001, uncorrected.
Results ALE meta-analysis of data from 21 experiments (totalling
527 foci) on empathic face processing during experimental task
conditions showed that emotional vs. neutral/control conditions
significantly correlated with activations of left anterior cingulate
cortex (BA 32), right precentral gyrus (BA 6), left amygdala, right
superior frontal gyrus (BA 9), left middle occipital gyrus (BA 37),
right insula (BA 13), left putamen, and left posterior cingulate cor-
tex (BA 31).
Conclusions Empathy is a complex process correlating with
activation of different brain areas, which have been involved
in emotional cue processing, self-other/same-different discrimi-
nation, perspective-taking, mirror neuron activation, emotional
arousal and decision-making.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.