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Page Background European Psychiatry 41S (2017) S69–S105

Available online at


25th European Congress of Psychiatry

Oral communications

Oral communications: Anxiety disorders and

somatoform disorders; depression;

obsessive-compulsive disorder and personality

and personality disorders


Impact of childhood trauma on the

course of panic disorder

M. De Venter

1 ,

, F. Van Den Eede


, T. Pattyn


, K. Wouters



D. Veltman

5 , B. P


6 , B. S




University Hospital Antwerp, Psychiatry, Lichtaart, Belgium


University Hospital Antwerp, Psychiatry, Edegem, Belgium


University of Antwerp UA, Collaborative Antwerp Psychiatric

Research Institute CAPRI, Wilrijk, Belgium


University Hospital Antwerp, Department of Scientific Coordination

and Biostat, Edegem, Belgium


VU University Medical Center, Department of Psychiatry- EMGO

Institute of Health care research, Amsterdam, The Netherlands


University Medical Center Groningen, Psychiatry, Groningen, The


Corresponding author.


To investigate the impact of childhood trauma on the

clinical course of panic disorder.


Longitudinal data of 539 participants with a current

panic disorder were collected from the Netherlands Study of

Depression and Anxiety (NESDA). Childhood trauma was assessed

with a structured interview and clinical course after two years with

a DSM-IV-based diagnostic interview and the Life Chart Interview.


At baseline, 56.3% reported childhood trauma, but this

was not predictive of persistence of panic disorder. Emotional

neglect and psychological abusewere associatedwithhigher occur-

rence of anxiety disorders other than panic disorder (social phobia)

and with higher chronicity of general anxiety symptoms (anxi-

ety attacks or episodes and avoidance). Baseline clinical features

(duration and severity of anxiety and depressive symptoms) and

personality traits (neuroticism and extraversion) accounted for

roughly 30 to 60% of the total effect of childhood trauma on

chronicity of anxiety symptoms and on occurrence of other anxiety



After two years, childhood trauma is associated with

chronicity of anxiety symptoms and occurrence of social phobia,

rather than persistence of panic disorder. These relationships are

partially accounted for by duration and severity of anxiety and

depressive symptoms, and neuroticism and extraversion.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Pharmacological and

psychotherapeutic interventions for

management of post-stroke

depression: A Bayesian network

meta-analysis of 27 randomized

controlled trials

L. Deng

West China Hospital Of Sichuan University, Stroke Clinical Research

Unit, Department of Neurology, Chengdu, China


Post-stroke depression (PSD) constitutes an impor-

tant complication of stroke, leading to great disability as well as

increased mortality. Since which treatment for PSD should be pre-

ferred are still matters of controversy, we aimed to compare and

rank these treatments.


We did a network meta-analysis to incorporate both

direct and indirect evidence from relevant trials by Bayesian ran-

dom effects model. We searched PubMed, the Cochrane Library

Central Register of Controlled Trials, Scopus, Embase for random-

ized controlled trials of different PSD treatments. The primary

outcomes were efficacy and tolerability. We assessed the quality

of evidence using the GRADE framework.


From 1347 citations, 27 randomised trials with a total of

1620 participants were included in this network meta-analysis.

In terms of primary outcome, only for reboxetione (standardised

mean difference [SMD]

12.84, 95% credible interval [CrI]



2.65) and nortriptyline (SMD

7.95, 95% CrI

14.85 to


enough evidence existed to support superiority compared with

placebo. No significant difference was observed in terms toler-

ability. Considering patient response rate, repetitive transcranial

magnetic stimulation (rTMS) was statistically more effective than

sertraline plus nimodipine (Relative risk [RR] 5.53, 95% CrI 1.36 to

23.86) and fluoxetine (RR 10.74, 95% CrI 3.55 to 35.97)


Compared with placebo, reboxetione and nortripty-

line offered a clear advantage for PSD patients. rTMS is probably

the best option to consider in addition of pharmacological treat-

ment. Nevertheless, doctors need to consider our results together