European Psychiatry - Volume 41 - April 2017

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S72 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105
observed, on the contrary, a significant association betweenWS and
weight gain at the end of treatment. HighWLR predicted remission
of binge eating and compensatory behavior in BN patients. We fur-
ther analyzed our data to identify threshold values of both WS and
WLR of clinical utility.
Conclusions The role of WS and WLR as predictive factors in the
outcome of eating disorders is of great interest and these initial
results remark the usefulness of collecting these data during the
initial assessment in order to plan a tailored therapeutic interven-
tion.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O009
Interaction between oxytocin gene
variants and perceived parenting in
relation to social anxiety in
adolescents: Evidence for differential
susceptibility effects
S. Olofsdotter ∗, C. Åslund , T. Furmark , E. Comasco ,
K. Nilsson
1 Uppsala University, Centre for Clinical Research, Västerås, Sweden
2 Uppsala University, Department of Psychology, Uppsala, Sweden
3 Uppsala University, Department of Neuroscience, Uppsala, Sweden
∗ Corresponding author.
Introduction Adolescence is a period of increasing demands in
independent social functioning where parenting style may have an
impact on social anxiety. A context-dependent effect of oxytocin
on human social behavior has been suggested, however research
on the gene coding for oxytocin (OXT) has mostly been reported
without considering contextual factors.
Aim This study investigated interactions between parenting
style and polymorphic variations in the OXT gene in association
with social anxiety symptoms in a community sample of adoles-
cents.
Methods The study group consisted of 1359 adolescents. Two sin-
gle nucleotide polymorphisms located near OXT, rs4813625 and
rs2770378, were genotyped. Social anxiety and perceived parent-
ing style were assessed by behavioral questionnaires.
Results Significant joint effects in line with the differential sus-
ceptibility frameworkwere observed for rs4813625with parenting
style. The levels of social anxiety among C allele carriers were
conditional on the level of supportive parenting style whereas
homozygote G carriers’ levels of social anxiety were unaffected by
supportive parenting style. The nature of the interactions between
rs2770378 and parenting stylewas in linewith the diatheses-stress
model. However, associations of rs2770378 and parenting style
with social anxiety became nonsignificant in nonlinear models.
Conclusions The study provides preliminary evidence for a mod-
ifying effect of supportive parenting style on the relationship
between rs4813625 and social anxiety symptoms in adoles-
cents, independent of sex. The findings may be interpreted from
the perspective of the social salience hypotheses of oxytocin,
with rs4813625 affecting social anxiety levels along a perceived
unsafe–safe social context dimension.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Oral communications: Anxiety disorders and
somatoform disorders; depression;
obsessive-compulsive disorder and personality
and personality disorders
O010
An investigation of the coupling of
temperament traits with major
depression
W. Sulis ∗, I. Trofimova
1 Mcmaster University, Psychiatry, Hamilton, Canada
2 McMaster University, Psychiatry and Behavioral Beuroscience,
Hamilton, Canada
∗ Corresponding author.
A diversity of neurochemical hypotheses related to major depres-
sion (MD) suggests that further investigation is needed for
uncovering the neurophysiological nature of MD. Since both tem-
perament andmental illness have been linked to varying degrees of
the same neurotransmitter imbalances in neurophysiological sys-
tems of behavioral regulation, the analysis of temperament traits as
weak forms of neurochemical imbalances might give new insights
into symptoms and nature of MD. This study analyzed the predic-
tions of the opioid receptor hypothesis within the neurochemical
model of functional ensemble of temperament proposing that a
dysregulation of the opioid receptors acting onmonoaminergic sys-
tems gives rise to the symptoms of major depression (MD). The
study investigated the coupling of sex, age and temperament traits
with MD across four age groups (17–24, 25–45, 46–65, 66–85) by
reviewing the records of testing in 423 patients and volunteerswith
(210) and without (213) the MD. The records included testing with
the personality assessment inventory, structure of temperament
questionnaire, structured clinical interview and other diagnos-
tic measures. In line with the hypothesis, patients with MD had
significantly lower physical endurance, social-verbal endurance,
mental endurance, plasticity, physical tempo, sensation seeking
and self-confidence, and higher impulsivity and neuroticism than
non-depressed individuals. Other sex- and age-related effects are
reported. The results suggest that new versions of the DSM should
consider an increase of impulsivity and a decrease in plasticity of
behavior as criteria symptoms of MD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O011
An investigation of the coupling of
temperament traits with anxiety
W. Sulis ∗, I. Trofimova
1 Mcmaster University, Psychiatry, Hamilton, Canada
2 McMaster University, Psychiatry and Behavioral Beuroscience,
Hamilton, Canada
∗ Corresponding author.
Temperament traits and anxiety have been linked to varying
degrees of neurotransmitter imbalances in neurophysiological sys-
tems of regulating behaviour. The diversity of neurotransmitters
implicated in anxiety symptoms raises questions as to whether
the multiple neurotransmitter systems secondarily express dys-
function in a higher-level system, which modulates their activity.
This study analyzed the predictions of the neurochemical func-
tional ensemble of temperament (FET) model that proposes that
a dysregulation of the opioid receptors acting on monoaminer-
gic and GABA systems gives rise to the symptoms of GAD. The
study investigated the coupling of sex, age and temperament traits
with generalized anxiety disorder (GAD) across three age groups