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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105

with all known safety and economy informationwhen selecting the

strategy for individual patients.

Disclosure of interest

The author has not supplied his declaration

of competing interest.


Assessing obsessive-compulsive

symptoms: The Portuguese version of

the Padua Inventory

A. Galhardo

1 ,

, J. P


a 2 , M.


1 ,

I. Massano-Cardoso



Miguel Torga Institute, CINEICC, Faculty of Psychology and

Educational Sciences of the University of Coimbra, Psychology,

Coimbra, Portugal


Faculty of Psychology and Educational Sciences of the University of

Coimbra, CINEICC, Coimbra, Portugal


Miguel Torga Institute, Psychology, Coimbra, Portugal

Corresponding author.


Self-report instruments are useful tools for the

assessment of psychopathological symptoms such as obsessive-

compulsive symptoms. The Padua Inventory (PI) is a measure that

has been widely used in clinical and research settings and studied

in several countries.


This study explores the psychometric properties and

factor structure of the Portuguese version of the PI.


Translation and translation-back of the original ver-

sion were executed. A total of 847 participants (468 women and

379 men) from the general population was recruited through a

snowball procedure and completed the PI and other mental health

measures. The data set was randomly split in order to conduct

principal component analysis (PCA) and confirmatory factor (CFA)

analysis in two different samples. Moreover, internal consistency,

convergent and discriminant validity and test-retest reliability

analyses were conducted.


From the PCA analysis four factors emerged, comprising

clusters of items related to doubting/impaired control over mental

activities, contamination/washing/cleaning, checking and worries

about losing control over motor behaviors. CFA results revealed

that the model presented a poor fit to the data and indicated that

the model would benefit from the establishment of correlations

between pairs of error terms of items with identical contents. The PI

exhibited excellent internal consistency, good test-retest reliability

and good convergent and discriminant validity.


The PI Portuguese version showed a similar factor

structure to the one presented in other studies and revealed good

psychometric properties. Nevertheless, results from the CFA sug-

gest that shortening the PI may be advantageous.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Oral communications: Anxiety disorders and

somatoform disorders; depression;

obsessive-compulsive disorder and personality

and personality disorders


Anti-basal ganglia antibodies (ABGA)

and excitatory neurotransmitters in

obsessive-compulsive disorder (OCD)

S. Gnanavel

1 ,

, A . P


2 , P. S


2 , V. S


3 , U.


4 ,

J. Nr



Northgate hospital, CYPS Child psychiatry, Morpeth, United



All India Institute of Medical Sciences, Psychiatry, New Delhi, India


AIIMS, Neurobiochemistry, New Delhi, India


AIIMS, NMR, New Delhi, India

Corresponding author.


OCD is a complex disorder with multiple aetiolog-

ical theories. Recent research points to role of autoimmunity as

well as hyperactivity of glutaminergic pathways in aetiopathogen-

esis of the disorder. It is possible that autoimmune mechanisms

may modulate excitatory neurotransmission resulting in OCD.


This study aimed to study the association

between serum anti-basal ganglia autoantibodies (ABGA) and Glx

(glutamate + glutamine) levels in caudate nucleus and anterior

cingulate cortex as demonstrated by


H-MRS (proton magnetic

resonance spectroscopy).


Thirty psychotropic-naive OCD patients and an equal

number of age, gender matched healthy controls were studied



H-MRS and levels of Glxwere obtained. ABGAwasmeasured

using ELISA (enzyme linked immunosorbent assay) technique and

categorised as present or absent in the serum.


ABGA was present in significantly higher proportion of

patients as compared to controls (


< 0.05). Glx level was signif-

icantly higher (as measured by


H-MRS) in patients with ABGA

as compared to those without ABGA (


= 0.02). The study results

did not differ based on age, gender, disease severity and illness



The study demonstrates presence of ABGA in at least

a subset of OCD population. The significant correlation between

brain Glx levels and presence of ABGA provides a putative neuro-

biological framework for OCD. The strengths of the study include

psychotropic-naive patients, blinded investigators and use of stan-

dardized instruments. The limitations include small sample size,

use of Glx as proxy measure of glutamate and lack of other disor-

der controls. Similar studies on a larger sample are warranted for a

better understanding.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Reaching out to patients with

antisocial personality disorder with

brief psychoeducation

M. Hesse

, B. T


Aarhus University, Department of Psychology, Aarhus, Denmark

Corresponding author.


Patients with antisocial personality disorder incur

high costs on society, and are at high risk of dropping out of treat-

ment and are often excluded fromtreatment, yet very little research

has been conducted on how to best help these patients.


To test a six-session psychoeducation program,

Impulsive Lifestyle Counselling, in outpatients with substance use

disorders and antisocial personality disorder.


To test the efficacy of the intervention versus treatment as

usual in community outpatient treatment for substance use disor-



Pragmatic randomized trial in 13 outpatient com-

munity substance abuse treatment uptake areas. Patients were

interviewed by blinded interviewers 3, 9 and 15 months post-

randomization and tracked through a national substance abuse

treatment register. Mixed effects regression were used to assess

substance use and self-reported aggression and Cox regression was

used to assess risk of dropout.