European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105 S73
(17–24, 25–45, 46–65 years). The records of patients aged 65–85
years old were also examined but showed significantly less pres-
ence of GAD in comparison to other age groups. Temperament was
assessed using the activity specific 12-trait structure of temper-
ament questionnaire. Consistent with the hypotheses of the FET,
patients with GAD reported lower mean scores on the traits of
social-verbal endurance, mental endurance, plasticity and sensa-
tion seeking and higher mean scores in the trait of impulsivity, than
healthy individuals. GAD was associated with significantly lower
self-confidence in women than in men. The results suggest that
new versions of the DSM should consider an increase of impulsi-
vity and a decrease in plasticity of behavior as criteria symptoms
of anxiety. Moreover, the results suggest that the current criterion
of fatigue should be specified as more related to social-verbal and
mental aspects and less to physical aspects of endurance.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O012
Predictors of remission at 1-year
follow-up among ocd patients:
Findings from The Netherlands
obsessive-compulsive disorder
association (NOCDA) study
L. Tibi ∗, P. van Oppen , A. van Balkom , M. Eikelenboom ,
G. Anholt
1 Ben Gurion University, Psychology, Be’er Sheva, Israel
2 VU University Medical Center, Psychiatry, Amsterdam, The
Netherlands
∗ Corresponding author.
Introduction Obsessive-compulsive disorder (OCD) is described
as a chronic condition. However, relatively little is known about
predictors affecting its long-term outcome.
Objective To examine the contribution of clinical and interper-
sonal determinants in predicting remission status of 254 OCD
patients at one-year follow-up (FU1).
Methods We used the baseline and FU1 data of The Nether-
lands obsessive-compulsive disorder association (NOCDA) study.
Clinical predictors were chronicity level, depressive and obsessive-
compulsive symptom severity. Suspected interpersonal factors
included attachment style, social support and expressed emotion.
Remission status was defined using the Yale-Brown obsessive-
compulsive symptom (Y-BOCS) scale. 2 tests and ANOVAs were
used for bivariate analyses, followed by multivariate multinomial
logistic regression analyses to assess main effects and interactions
in predicting remission status at FU1.
Results Bivariate tests demonstrated significant differences in
remission status as a function of chronicity level, depressive
and obsessive-compulsive symptom severity and social support.
Regression analyses revealed that increased baseline OCD sever-
ity reduced the odds for both partial and full remission at FU1
(OR = .87, 95%CI = .82–93, P < 0.001). Increased depressive severity
at baseline reduced the odds for partial remission at FU1 (OR = .95,
95%CI = .91–.98, P < 0.01). Interactions analyses demonstrated that
the adverse effects of OCD severity onpartial remissiondisappeared
at the presence of secure attachment (IOR = 1.11, 95%CI = 1.05–1.24,
P < 0.05) and high social support (IOR = .88, 95%CI = .78–98, P < 0.05).
Conclusions The contribution of clinical severity is critical for
understanding the prognosis of OCD. The interpersonal context of
OCD patients may mitigate the unfavorable effect of severity on
outcome, thus should be addressed in treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O013
The effectiveness of the inference
based approach to treating
obsessive-compulsive disorder with
poor insight; a randomized controlled
multicentre trial
H. Visser ∗, H. van Megen , T. van Balkom
1 GGZ centraal, psychiatry, Amersfoort, The Netherlands
2 GGZ ingeest, psychiatry, Amsterdam, The Netherlands
∗ Corresponding author.
Background There is an urgent need for an effective psychological
treatment for patients with obsessive compulsive disorder (OCD)
with poor insight, since this disorder is associated with severe suf-
fering and a low quality of life. The inference based approach (IBA),
a new psychotherapy for OCD specifically targets insight in OCD.
In a randomized controlled multicentre trial, the effectiveness of
IBA was compared to the effectiveness of CBT for treating patients
with OCD with poor insight. In this study, 24 sessions of IBA were
tested versus 24 sessions of CBT. Ninety patients with a main diag-
nosis of OCD with poor insight according to the DSM-IV criteria
participated in the study. The primary outcome was reduction of
the obsessive-compulsive symptoms.
Results In both conditions, a significant OCD symptom reduction
was reached, but no condition effects were established. Post hoc,
in a small subgroup of patients with the worst insight (n = 23), it
was found that the patients treated with the IBA reached a signif-
icantly higher OCD symptom reduction than patients treated with
CBT [estimated marginal mean = –7.77, t(219.45) = –2.4, P= 0.017].
Of patients treated with IBA, 41.9% were responder and 20.9% com-
pletely recovered. Of the patients treated with CBT, 42.6% were
responder and 12.8% recovered.
Conclusion Patients with OCD with poor insight improve sig-
nificantly after psychological treatment. The results of this study
suggest that both CBT and the IBA are effective treatments for OCD
with poor insight. The IBA might be more promising than CBT for
patients with more extreme poor insight.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Oral communications: Bipolar disorders
O014
Thyroid profile and its relationship
with response to treatment with
lithium in bipolar mood disorder
patients
P. Avinash ∗, K. Pathak
1 Himalayan Institute Of Medical Sciences, Psychiatry, Motihari, India
2 Lgb Regional Institute Of Mental Health, Psychiatry, Tezpur, India
∗ Corresponding author.
Introduction There is substantial evidence that even minor per-
turbation of thyroid function plays a significant role in clinical
course and treatment outcome in depressive disorder; however the
same is not yet clear in bipolar disorders.
Aims and objectives To study the relationship between pretreat-
ment thyroid profile and response to treatment with lithium along
with other predictors of response to treatment with lithium in cases
of bipolar mood disorder.
Methods This study was conducted in the indoor facilities of a
regional Institute of Mental Health, Tezpur, India in the year of