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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105


(17–24, 25–45, 46–65 years). The records of patients aged 65–85

years old were also examined but showed significantly less pres-

ence of GAD in comparison to other age groups. Temperament was

assessed using the activity specific 12-trait structure of temper-

ament questionnaire. Consistent with the hypotheses of the FET,

patients with GAD reported lower mean scores on the traits of

social-verbal endurance, mental endurance, plasticity and sensa-

tion seeking and higher mean scores in the trait of impulsivity, than

healthy individuals. GAD was associated with significantly lower

self-confidence in women than in men. The results suggest that

new versions of the DSM should consider an increase of impulsi-

vity and a decrease in plasticity of behavior as criteria symptoms

of anxiety. Moreover, the results suggest that the current criterion

of fatigue should be specified as more related to social-verbal and

mental aspects and less to physical aspects of endurance.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Predictors of remission at 1-year

follow-up among ocd patients:

Findings from The Netherlands

obsessive-compulsive disorder

association (NOCDA) study

L. Tibi

1 ,

, P. van Oppen


, A. van Balkom


, M. Eikelenboom



G. Anholt



Ben Gurion University, Psychology, Be’er Sheva, Israel


VU University Medical Center, Psychiatry, Amsterdam, The


Corresponding author.


Obsessive-compulsive disorder (OCD) is described

as a chronic condition. However, relatively little is known about

predictors affecting its long-term outcome.


To examine the contribution of clinical and interper-

sonal determinants in predicting remission status of 254 OCD

patients at one-year follow-up (FU1).


We used the baseline and FU1 data of The Nether-

lands obsessive-compulsive disorder association (NOCDA) study.

Clinical predictors were chronicity level, depressive and obsessive-

compulsive symptom severity. Suspected interpersonal factors

included attachment style, social support and expressed emotion.

Remission status was defined using the Yale-Brown obsessive-

compulsive symptom (Y-BOCS) scale.


tests and ANOVAs were

used for bivariate analyses, followed by multivariate multinomial

logistic regression analyses to assess main effects and interactions

in predicting remission status at FU1.


Bivariate tests demonstrated significant differences in

remission status as a function of chronicity level, depressive

and obsessive-compulsive symptom severity and social support.

Regression analyses revealed that increased baseline OCD sever-

ity reduced the odds for both partial and full remission at FU1

(OR = .87, 95%CI = .82–93,


< 0.001). Increased depressive severity

at baseline reduced the odds for partial remission at FU1 (OR = .95,

95%CI = .91–.98,


< 0.01). Interactions analyses demonstrated that

the adverse effects of OCD severity onpartial remissiondisappeared

at the presence of secure attachment (IOR = 1.11, 95%CI = 1.05–1.24,


< 0.05) and high social support (IOR = .88, 95%CI = .78–98,


< 0.05).


The contribution of clinical severity is critical for

understanding the prognosis of OCD. The interpersonal context of

OCD patients may mitigate the unfavorable effect of severity on

outcome, thus should be addressed in treatment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


The effectiveness of the inference

based approach to treating

obsessive-compulsive disorder with

poor insight; a randomized controlled

multicentre trial

H. Visser

1 ,

, H. van Megen


, T. van Balkom



GGZ centraal, psychiatry, Amersfoort, The Netherlands


GGZ ingeest, psychiatry, Amsterdam, The Netherlands

Corresponding author.


There is an urgent need for an effective psychological

treatment for patients with obsessive compulsive disorder (OCD)

with poor insight, since this disorder is associated with severe suf-

fering and a low quality of life. The inference based approach (IBA),

a new psychotherapy for OCD specifically targets insight in OCD.

In a randomized controlled multicentre trial, the effectiveness of

IBA was compared to the effectiveness of CBT for treating patients

with OCD with poor insight. In this study, 24 sessions of IBA were

tested versus 24 sessions of CBT. Ninety patients with a main diag-

nosis of OCD with poor insight according to the DSM-IV criteria

participated in the study. The primary outcome was reduction of

the obsessive-compulsive symptoms.


In both conditions, a significant OCD symptom reduction

was reached, but no condition effects were established. Post hoc,

in a small subgroup of patients with the worst insight (


= 23), it

was found that the patients treated with the IBA reached a signif-

icantly higher OCD symptom reduction than patients treated with

CBT [estimated marginal mean = –7.77, t(219.45) = –2.4,


= 0.017].

Of patients treated with IBA, 41.9% were responder and 20.9% com-

pletely recovered. Of the patients treated with CBT, 42.6% were

responder and 12.8% recovered.


Patients with OCD with poor insight improve sig-

nificantly after psychological treatment. The results of this study

suggest that both CBT and the IBA are effective treatments for OCD

with poor insight. The IBA might be more promising than CBT for

patients with more extreme poor insight.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Oral communications: Bipolar disorders


Thyroid profile and its relationship

with response to treatment with

lithium in bipolar mood disorder


P. Avinash

1 ,

, K. Pathak



Himalayan Institute Of Medical Sciences, Psychiatry, Motihari, India


Lgb Regional Institute Of Mental Health, Psychiatry, Tezpur, India

Corresponding author.


There is substantial evidence that even minor per-

turbation of thyroid function plays a significant role in clinical

course and treatment outcome in depressive disorder; however the

same is not yet clear in bipolar disorders.

Aims and objectives

To study the relationship between pretreat-

ment thyroid profile and response to treatment with lithium along

with other predictors of response to treatment with lithium in cases

of bipolar mood disorder.


This study was conducted in the indoor facilities of a

regional Institute of Mental Health, Tezpur, India in the year of