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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105


screening instrument in the nationwide general population of

South Korea.


A total of 3013 adults among the 2011 Korean Epidemi-

ologic Catchment Area survey (KECA-2011) completed face-to-face

interviews using the Korean versions of the composite interna-

tional diagnostic interview 2.1 and mood disorder questionnaire

(K-CIDI and K-MDQ).


The lifetime prevalence of BPS in the South Korean adults

wasmeasured to be 4.3% (95% CI 2.6–6.9). Nearly 80% of the subjects

with BPS were codiagnosed with other DSM-IV nonpsychotic men-

tal disorders: 35.4% (95% CI 24.2–48.5) for major depression and

dysthymic disorder, 35.1% (95% CI 27.7–43.3) for anxiety disorders

and 51.9% (95% CI 40.5–63.1) for alcohol and nicotine use disorders.

Younger age (18–34 years) was the only sociodemographic predic-

tor of BPS positivity (


= 0.014) and the diagnostic overlap patterns

were different between men and women.


Positivity for BPS was estimated to be much greater

than the prevalence of DSM-IV BP in South Korea. Most of the

respondentswith BPSwere diagnosedwith othermajormental dis-

orders and this might be related with mis and/or underdiagnosis of

clinically relevant Sub-BP.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Assessment of serum IL-4, 15d-PGJ2,

PPAR gamma levels in patients with

bipolar disorder

G. Erzin

1 ,

, C¸ . aydemir


, R. yüksel


, E. tatlıdil


, B. C¸ akır



S. sezer


, E. göka



Dıskapı Yıldırım Beyazıt Education and Research Hospital,

Psychiatry, Ankara, Turkey


Ankara Numune Education and Research Hospital, Psychiatry,

Ankara, Turkey


Ankara Numune Education and Research Hospital, Biochemistry,

Ankara, Turkey

Corresponding author.


Many hypotheses have been proposed about devel-

opment of bipolar disorder including inflammatory processes due

to the external and endogenous factors. There are strong evidences

that immunological dysfunction is present in bipolar disorder. In

the pathophysiology of bipolar disorder, there are many data that

support the inflammatory hypothesis.


In this study, to clarify the etiology of bipolar disorder,

based on the inflammatory process hypothesis, it is aimed to mea-

sure and evaluate serum 15d-PGJ2 and PPAR , anti-inflammatory

cytokine IL-4 levels in patients with bipolar disorder.


This study was performed at Ankara Numune Train-

ing and Research Hospital. Ninety-five patients are included in the

study that were in their mania or remission periods and meet the

DSM-V criteria for bipolar disorder. Forty-four healthy volunteers

are included in the study as well. Serum IL-4, 15d-PGJ2, PPAR

levels are measured in both groups. Young Mania Scale, Hamil-

ton Depression Scale, demographic data formwere given to patient



In our study, 15d-PGJ2, PPAR levels were found statisti-

cally significantly lower in patients with bipolar disorder compared

to healthy controls.


There are differences in anti-inflammatory

prostaglandin levels in patients with bipolar disorder who

are in their mania period when compared to healthy controls

and patients in their remission period. This does not show any

significance according to smoking and gender. This implies that

inflammation markers could be a good candidate to determine

trait markers, which will provide an insight for preventing patient

from mania period or prognosis after the diagnosis of bipolar


Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Impulsivity and brain volume in

patients with bipolar disorder type I

and bipolar disorder type II

D. Janiri

, G. G

iuseppin , E. Spinazzola , M. Maggiora , G. Sani

Sapienza University of Rome- Faculty of Medicine and Psychology,

NESMOS Department Neurosciences- Mental Health and Sensory

Functions, Rome, Italy

Corresponding author.


Impulsivity is a key feature of both bipolar disorder

(BD) type I (BDI) and type II (BDII).


Structural neuroimaging studies help clarifying brain

mechanisms underpinning the regulation of impulsivity in BDI and



To address the question whether grey matter (GM) alter-

ations relate differently with impulsivity in BDI and BDII.


We assessed 54 euthymic outpatients, diagnosed with



= 28) or BDII (


= 26) according to DSM-IV-TR criteria. They

underwent a 3 T magnetic resonance imaging (MRI) investigation.

GM brain volumes were analyzed on a voxel-by-voxel basis using

Statistical Parametric Mapping 8. The Barratt Impulsiveness Scale

(BIS), version 11A, was used to assess trait impulsivity.


BDI and BDII patients present an inverse relationship

between impulsivity and GM volume in two cerebral areas: the

right cerebellum (right crus I) and the interface between the left

angular gyrus and the left inferior parietal cortex (Brodmann Area

39, 7, 40). More specifically, a negative relationship for BPI and a

positive relationship for BPII were found in both areas.


Results suggest that the different diagnosis between

BDI and BDII could have a significant effect on GM changes

according to impulsivity severity and point up the importance of

considering the BP subtype distinction in neuroimaging studies on

this topic.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Inflammation and neurodegeneration

findings in early stage bipolar disorder

S. Karabulut

1 ,

, U. Akcan


, ˙I.C. Küc¸ ükali


, E. Tüzün


, S. C¸ akır



˙Istanbul Medical Faculty, Psychiatry Department, Istanbul, Turkey


Institute of Experimental Medicine, Neuroscience, Istanbul, Turkey

Corresponding author.


There is growing evidence about neuroinflamma-

tion in the aetiopathogenesis of bipolar disorder. Early diagnosis

and intervention strategies are thought to be excessively important



To check neuroinflammation levels in early stage

bipolar disorder and explore the associationswith clinical variables.


We aimed to evaluate inflammation and neurodegenera-

tion findings in early stage bipolar disorder.


Serum interleukin 1-receptor antagonist (IL-1Ra), inter-

leukin 6 (IL-6), tumor necrosis factor-alpha (TNF- ), high sensitive

C reactive protein (hs-CRP), S100B and neuron specific enolase

(NSE) levels were assessed by enzyme-linked immunosorbent

assays in a total of 30 patients with bipolar disorder in the early

stage and compared with 30 matched healthy controls. The clinical

symptoms were rated using Montgomery Asberg Depression Scale,