European Psychiatry - Volume 41 - April 2017

79 / 916

25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105 S75
screening instrument in the nationwide general population of
South Korea.
Methods A total of 3013 adults among the 2011 Korean Epidemi-
ologic Catchment Area survey (KECA-2011) completed face-to-face
interviews using the Korean versions of the composite interna-
tional diagnostic interview 2.1 and mood disorder questionnaire
(K-CIDI and K-MDQ).
Results The lifetime prevalence of BPS in the South Korean adults
wasmeasured to be 4.3% (95% CI 2.6–6.9). Nearly 80% of the subjects
with BPS were codiagnosed with other DSM-IV nonpsychotic men-
tal disorders: 35.4% (95% CI 24.2–48.5) for major depression and
dysthymic disorder, 35.1% (95% CI 27.7–43.3) for anxiety disorders
and 51.9% (95% CI 40.5–63.1) for alcohol and nicotine use disorders.
Younger age (18–34 years) was the only sociodemographic predic-
tor of BPS positivity (P = 0.014) and the diagnostic overlap patterns
were different between men and women.
Conclusions Positivity for BPS was estimated to be much greater
than the prevalence of DSM-IV BP in South Korea. Most of the
respondentswith BPSwere diagnosedwith othermajormental dis-
orders and this might be related with mis and/or underdiagnosis of
clinically relevant Sub-BP.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O018
Assessment of serum IL-4, 15d-PGJ2,
PPAR gamma levels in patients with
bipolar disorder
G. Erzin ∗, C¸ . aydemir , R. yüksel , E. tatlıdil , B. C¸ akır ,
S. sezer , E. göka
1 Dıskapı Yıldırım Beyazıt Education and Research Hospital,
Psychiatry, Ankara, Turkey
2 Ankara Numune Education and Research Hospital, Psychiatry,
Ankara, Turkey
3 Ankara Numune Education and Research Hospital, Biochemistry,
Ankara, Turkey
∗ Corresponding author.
Introduction Many hypotheses have been proposed about devel-
opment of bipolar disorder including inflammatory processes due
to the external and endogenous factors. There are strong evidences
that immunological dysfunction is present in bipolar disorder. In
the pathophysiology of bipolar disorder, there are many data that
support the inflammatory hypothesis.
Objectives In this study, to clarify the etiology of bipolar disorder,
based on the inflammatory process hypothesis, it is aimed to mea-
sure and evaluate serum 15d-PGJ2 and PPAR , anti-inflammatory
cytokine IL-4 levels in patients with bipolar disorder.
Methods This study was performed at Ankara Numune Train-
ing and Research Hospital. Ninety-five patients are included in the
study that were in their mania or remission periods and meet the
DSM-V criteria for bipolar disorder. Forty-four healthy volunteers
are included in the study as well. Serum IL-4, 15d-PGJ2, PPAR
levels are measured in both groups. Young Mania Scale, Hamil-
ton Depression Scale, demographic data formwere given to patient
group.
Results In our study, 15d-PGJ2, PPAR levels were found statisti-
cally significantly lower in patients with bipolar disorder compared
to healthy controls.
Conclusion There are differences in anti-inflammatory
prostaglandin levels in patients with bipolar disorder who
are in their mania period when compared to healthy controls
and patients in their remission period. This does not show any
significance according to smoking and gender. This implies that
inflammation markers could be a good candidate to determine
trait markers, which will provide an insight for preventing patient
from mania period or prognosis after the diagnosis of bipolar
disorder.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O019
Impulsivity and brain volume in
patients with bipolar disorder type I
and bipolar disorder type II
D. Janiri∗ iuseppin , E. Spinazzola , M. Maggiora , G. Sani
Sapienza University of Rome- Faculty of Medicine and Psychology,
NESMOS Department Neurosciences- Mental Health and Sensory
Functions, Rome, Italy
∗ Corresponding author.
Introduction Impulsivity is a key feature of both bipolar disorder
(BD) type I (BDI) and type II (BDII).
Objective Structural neuroimaging studies help clarifying brain
mechanisms underpinning the regulation of impulsivity in BDI and
BDII.
Aims To address the question whether grey matter (GM) alter-
ations relate differently with impulsivity in BDI and BDII.
Methods We assessed 54 euthymic outpatients, diagnosed with
BDI (n = 28) or BDII (n = 26) according to DSM-IV-TR criteria. They
underwent a 3 T magnetic resonance imaging (MRI) investigation.
GM brain volumes were analyzed on a voxel-by-voxel basis using
Statistical Parametric Mapping 8. The Barratt Impulsiveness Scale
(BIS), version 11A, was used to assess trait impulsivity.
Results BDI and BDII patients present an inverse relationship
between impulsivity and GM volume in two cerebral areas: the
right cerebellum (right crus I) and the interface between the left
angular gyrus and the left inferior parietal cortex (Brodmann Area
39, 7, 40). More specifically, a negative relationship for BPI and a
positive relationship for BPII were found in both areas.
Conclusions Results suggest that the different diagnosis between
BDI and BDII could have a significant effect on GM changes
according to impulsivity severity and point up the importance of
considering the BP subtype distinction in neuroimaging studies on
this topic.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O020
Inflammation and neurodegeneration
findings in early stage bipolar disorder
S. Karabulut ∗, U. Akcan , ˙I.C. Küc¸ ükali , E. Tüzün , S. C¸ akır
1 ˙Istanbul Medical Faculty, Psychiatry Department, Istanbul, Turkey
2 Institute of Experimental Medicine, Neuroscience, Istanbul, Turkey
∗ Corresponding author.
Introduction There is growing evidence about neuroinflamma-
tion in the aetiopathogenesis of bipolar disorder. Early diagnosis
and intervention strategies are thought to be excessively important
lately.
Objectives To check neuroinflammation levels in early stage
bipolar disorder and explore the associationswith clinical variables.
Aims We aimed to evaluate inflammation and neurodegenera-
tion findings in early stage bipolar disorder.
Methods Serum interleukin 1-receptor antagonist (IL-1Ra), inter-
leukin 6 (IL-6), tumor necrosis factor-alpha (TNF- ), high sensitive
C reactive protein (hs-CRP), S100B and neuron specific enolase
(NSE) levels were assessed by enzyme-linked immunosorbent
assays in a total of 30 patients with bipolar disorder in the early
stage and compared with 30 matched healthy controls. The clinical
symptoms were rated using Montgomery Asberg Depression Scale,