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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105

Young Mania Rating Scale, Positive and Negative Syndrome Scale

and Clinical Global Impression Scale.


Among the patients with bipolar disorder, 14 (% 46.6)

were in a manic/hypomanic state and 12 (% 40) were in a euthymic

state. Serum IL-6 levels were significantly higher (


= 0.018), TNF-

and S100B levels were significantly lower in the early stage group



< 0.001 and


= 0.03, respectively). After repeated analysis with

only drug-naive patients, the results showed no difference. There

was a positive and significant correlation between TNF- levels

and CGI, MADRS scores (all


< 0.05); NSE levels and MADRS scores



< 0.05).


This study supported the association of early stage

bipolar disorder with inflammation and neurodegeneration. IL-6

may be a potential biomarker. Thus, early diagnosis and interven-

tion may be crucial to prevent progressive neuroinflammation and

neurodegeneration in early stages of disorder.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


The correlation between plasma

brain-derived neurotrophic factor and

cognitive function in bipolar disorder

is modulated by the BDNF Val66Met


S.Y. Lee

Kaohsiung Veterans General Hospitan, Psychiatry, Kaohsiung,

Taiwan ROC


Brain-derived neurotrophic factor (BDNF) may be

involved in the pathogenesis of bipolar disorder (BD). The func-

tional BDNF Val66Met polymorphism (rs6265) is associated with

secretion of BDNF. The current study aimed to explore the cor-

relation between changes of plasma BDNF and cognitive function

after 12 week of treatment, considering the influence of the BDNF

val66Met polymorphism. The correlation of changes of plasma

BDNF with quality of life (QOL) was explored.


First diagnosed patients with BD were recruited. Symp-

tom severity, plasma BDNF levels were examined during weeks 0,

1, 2, 4, 8, and 12. QOL, Wisconsin Card Sorting Test (WCST) and

the Conners’ Continuous Performance Test (CPT) were assessed at

baseline and endpoint. The genotype of the BDNF Val66Met poly-

morphism was determined. The change of cognitive function and

QOLmeasures over 12weeks were reduced by factor analysis. Pear-

son’s correlation was used to investigate the association between

change of plasma BDNF levels with cognitive function and QOL.


Five hundred and forty-one BP patients were recruited.

Three hundred and fifty-five (65.6%) patients completed the 12-

week follow-up. A significant negative correlation was found

between changes of plasma BDNF level with factor 1 (WCST)






< 0.001). After further stratification according to sub-

types of BD and the BDNF genotypes, above significant correlation

was found only in those with BP-I and the BDNF Val66Met Val/Met

genotype (





< 0.008).


We conclude that changes in plasma BDNF signifi-

cantly correlated with changes in WCST in patients with BD; such

correlation ismoderated by the BDNF Val66Met polymorphismand

subtype of BD.

Disclosure of interest

The author has not supplied his declaration

of competing interest.


Cortical inhibition in symptomatic

and remitted mania compared to

healthy subjects: A paired-pulse TMS


N. Sanjay

, R. Basavaraju , S. Biradar , U. Mehta , M. Kesavan ,

J. Thirthalli , V. Ganesan

Nation Institute of Mental Health and Neuro Sciences NIMHANS,

Department of Psychiatry, Bangalore, India

Corresponding author.


Cortical inhibition (CI) is a neurophysiological out-

come of the interaction between GABA inhibitory interneurons and

other excitatory neurons. Transcranial magnetic stimulation (TMS)

measures of CI deficits have been documented in both symptomatic

and remitted bipolar disorder (BD) suggesting it could be a trait

marker. The effects of medications and duration of illness may

contribute to these findings.


To study CI in BD.


To compare CI across early-course medication-naive BD-

mania, remitted first episode mania (FEM) and healthy subjects



Symptomatic BD subjects having < 3 episodes, currently

in mania and medication-naive (


= 27), remitted FEM (


= 27;

YMRS < 12 and HDRS < 8) and 45 HS, matched for age and gender,

were investigated. Resting motor threshold (RMT) and 1-millivolt

motor threshold (MT1) were estimated from the right first dor-

sal interosseous muscle. Paired-pulse TMS measures of short (SICI;

3ms) and long interval intracortical inhibition (LICI; 100ms) were

acquired. Group differences inmeasures of CI were examined using



Table 1 .


Symptomatic mania patients had the highest motor

thresholds and the maximum LICI indicating a state of an exces-

sive GABA-B neurotransmitter tone. Remitted mania patients had

deficits in SICI indicating reduced GABA-A neurotransmitter tone.

Putative changes in GABA-A neurotransmitter system activity with

treatment may be investigated in future studies. CI has received

less attention in BD as compared to schizophrenia and is a potential

avenue for future research in this area.

Table 1

Measures of motor threshold and CI across the three



Degrees of freedom 2,96.


Probability error for the omni-bus test.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.