European Psychiatry - Volume 41 - April 2017

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S76 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105
Young Mania Rating Scale, Positive and Negative Syndrome Scale
and Clinical Global Impression Scale.
Results Among the patients with bipolar disorder, 14 (% 46.6)
were in a manic/hypomanic state and 12 (% 40) were in a euthymic
state. Serum IL-6 levels were significantly higher (P = 0.018), TNF-
and S100B levels were significantly lower in the early stage group
(P < 0.001 and P = 0.03, respectively). After repeated analysis with
only drug-naive patients, the results showed no difference. There
was a positive and significant correlation between TNF- levels
and CGI, MADRS scores (all P< 0.05); NSE levels and MADRS scores
(P < 0.05).
Conclusions This study supported the association of early stage
bipolar disorder with inflammation and neurodegeneration. IL-6
may be a potential biomarker. Thus, early diagnosis and interven-
tion may be crucial to prevent progressive neuroinflammation and
neurodegeneration in early stages of disorder.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
O021
The correlation between plasma
brain-derived neurotrophic factor and
cognitive function in bipolar disorder
is modulated by the BDNF Val66Met
polymorphism
S.Y. Lee
Kaohsiung Veterans General Hospitan, Psychiatry, Kaohsiung,
Taiwan ROC
Objectives Brain-derived neurotrophic factor (BDNF) may be
involved in the pathogenesis of bipolar disorder (BD). The func-
tional BDNF Val66Met polymorphism (rs6265) is associated with
secretion of BDNF. The current study aimed to explore the cor-
relation between changes of plasma BDNF and cognitive function
after 12 week of treatment, considering the influence of the BDNF
val66Met polymorphism. The correlation of changes of plasma
BDNF with quality of life (QOL) was explored.
Methods First diagnosed patients with BD were recruited. Symp-
tom severity, plasma BDNF levels were examined during weeks 0,
1, 2, 4, 8, and 12. QOL, Wisconsin Card Sorting Test (WCST) and
the Conners’ Continuous Performance Test (CPT) were assessed at
baseline and endpoint. The genotype of the BDNF Val66Met poly-
morphism was determined. The change of cognitive function and
QOLmeasures over 12weeks were reduced by factor analysis. Pear-
son’s correlation was used to investigate the association between
change of plasma BDNF levels with cognitive function and QOL.
Results Five hundred and forty-one BP patients were recruited.
Three hundred and fifty-five (65.6%) patients completed the 12-
week follow-up. A significant negative correlation was found
between changes of plasma BDNF level with factor 1 (WCST)
(r = −0.25, P < 0.001). After further stratification according to sub-
types of BD and the BDNF genotypes, above significant correlation
was found only in those with BP-I and the BDNF Val66Met Val/Met
genotype (r = −0.54, P < 0.008).
Conclusion We conclude that changes in plasma BDNF signifi-
cantly correlated with changes in WCST in patients with BD; such
correlation ismoderated by the BDNF Val66Met polymorphismand
subtype of BD.
Disclosure of interest The author has not supplied his declaration
of competing interest.
O022
Cortical inhibition in symptomatic
and remitted mania compared to
healthy subjects: A paired-pulse TMS
study
N. Sanjay∗, R. Basavaraju , S. Biradar , U. Mehta , M. Kesavan ,
J. Thirthalli , V. Ganesan
Nation Institute of Mental Health and Neuro Sciences NIMHANS,
Department of Psychiatry, Bangalore, India
∗ Corresponding author.
Introduction Cortical inhibition (CI) is a neurophysiological out-
come of the interaction between GABA inhibitory interneurons and
other excitatory neurons. Transcranial magnetic stimulation (TMS)
measures of CI deficits have been documented in both symptomatic
and remitted bipolar disorder (BD) suggesting it could be a trait
marker. The effects of medications and duration of illness may
contribute to these findings.
Objective To study CI in BD.
Aims To compare CI across early-course medication-naive BD-
mania, remitted first episode mania (FEM) and healthy subjects
(HS).
Methods Symptomatic BD subjects having < 3 episodes, currently
in mania and medication-naive ( n = 27), remitted FEM (n = 27;
YMRS < 12 and HDRS < 8) and 45 HS, matched for age and gender,
were investigated. Resting motor threshold (RMT) and 1-millivolt
motor threshold (MT1) were estimated from the right first dor-
sal interosseous muscle. Paired-pulse TMS measures of short (SICI;
3ms) and long interval intracortical inhibition (LICI; 100ms) were
acquired. Group differences inmeasures of CI were examined using
ANOVA.
Results
Conclusions Symptomatic mania patients had the highest motor
thresholds and the maximum LICI indicating a state of an exces-
sive GABA-B neurotransmitter tone. Remitted mania patients had
deficits in SICI indicating reduced GABA-A neurotransmitter tone.
Putative changes in GABA-A neurotransmitter system activity with
treatment may be investigated in future studies. CI has received
less attention in BD as compared to schizophrenia and is a potential
avenue for future research in this area.
Table 1 Measures of motor threshold and CI across the three
groups.
aDegrees of freedom 2,96.
bProbability error for the omni-bus test.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.