European Psychiatry - Volume 41 - April 2017

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S668 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S645–S709
EV0808
Invisible effects of chemotherapy
D. Brandão , T. Assunc¸ ão , H. Almeida ∗
1 Interna Psiquiatria ULSAM, Departamento de Psiquiatria e Saúde
Mental da ULSAM, Braga, Portugal
2 IPO-Porto, Porto, Portugal
3 Hospital Magalhães Lemos, B, Porto, Portugal
4 University of Porto, Department of Clinical Neurosciences and
Mental Health Faculty of Medicine, Porto, Portugal
∗ Corresponding author.
Introduction Chemotherapy is an essential component in the
treatment and alleviation of oncological diseases. To your appli-
cation are associated, as well as systemic effects, cognitive
impairment in patients. These changes have received increasing
attention due to the impact on quality of life of cancer survivors.
Objectives This study aims to evaluate the current evidence
on the association between chemotherapy and cognitive impair-
ment in cancer patients, especially in the areas affected cognitive
function, possible mechanisms of action and consequences on
the quality of life of these patients and the importance of
identifying strategies intervention in order to minimize these
effects.
Methods We conducted a literature review from literature arti-
cles addressing this topic with use of databases: Medline and
Pubmed. The following keywords were used: “chemobrain”, “cog-
nitive dysfunction”, “chemotherapy”.
Results Although some states have not found differences, sev-
eral studies have shown that chemotherapy has implications
cognitively. Underlying etiology remains unknown, and proposed
several mechanisms to explain these changes: neurotoxicity,
microvascular damage and inflamamatory response. Cognitive
impairment has significant implications in the daily life of
patients both personally, socially and labour. The therapeutic
approach focuses on the patient and family education, cop-
ing strategies, cognitive rehabilitation and cognitive behavioural
therapy.
Conclusions It is vital to educate patients about the possibility of
cognitive change as effect of chemotherapy as well as health pro-
fessionals in the early identification of these changes. It is essential
developing specific intervention strategies to improve the quality
of life of the oncologic patient during and after treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0809
The study and comparison of the
severity of coping strategies and
defense mechanisms in prostate
cancer patients, healthy individuals
and patients with similar localization
oncology
J. Gardanova ∗, I. Abdullin , A. Chernov , D. Khritinin
Pirogov Russian National Research Medical University,
Psychotherapy, Moscow, Russia
∗ Corresponding author.
This project deals with the problem of emotional response to
their disease in prostate cancer patients compared with healthy
people and patients with similar localization of oncology dis-
eases. As a result, it was found that in patients with prostate
cancer pronounced such defense mechanisms as repression,
denial and reaction formation, which may lead to psychosomatic
disease. The coping strategies of the system in patients with
prostate cancer is most pronounced, such a mechanism as a
“distancing”. The results may contribute to the creation of a
specific psychological rehabilitation for this group of patients the
program.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0810
Bruxism as a consequence of
chemotherapy?
G. Da Ponte ∗ ato into Lobo uakinin
1 Centro Hospitalar Barreiro-Montijo, Psychiatry and Mental Health,
Barreiro, Portugal
2 Centro Hospitalar Barreiro-Montijo, Oncology, Barreiro, Portugal
3 Medical School of Lisbon University, University Clinic of Psychiatry
and Medical Psychology, Lisbon, Portugal
∗ Corresponding author.
Introduction Bruxism is a syndrome with uncertain etiology
but with proposed factors: psychosocial, peripheral and cen-
tral. Treatment is also controversial and one of the options
focuses in GABA theory and regularization of ion channels.
Xelox (capecitabine + oxaliplatin) and bevacizumad is indicated for
metastatic colorectal cancer, being oxaliplatin the most neuro-
toxic agent (acute syndrome and/or a chronic sensory neuropathy).
Acute neurotoxicity is very frequent and it is a sensory and/or a
motor toxicity (as tongue tingling or jaw spams). The proposed
pathogenesis – neuronal hyperexcitability due to alterations of
voltage-gated ion channels – is supported by mechanism of action
of some treatments.
Objectives and Aims Review different causes of bruxism.
Methods Description of a clinical case.
Results This is a story of 76-years-old man in treatment for
metastatic colon cancer that developed toxicity: nauseas (treated
with haloperidol), bruxismand gingival atrophy. Hewas referred to
psycho-oncology by involuntary movements of mouth and trunk.
The patient complained of sadness, anhedonia and insomnia since
recurrence of cancer and related the movements with CT. At obser-
vation he was anxious, tearfulness and agitated. He was treated for
a depressive episode, but the doubt remained about involuntary
movements: haloperidol was a confounding factor for oxaliplatin
acute neurotoxicity, also aggravated by psychic and peripheral fac-
tors.
Conclusions The authors believe that bruxism is linked to CT in
a very complex relation that includes psychic, peripheral and cen-
tral factors. Psychiatrists need to keep attention to the patient as a
whole, not being seduced by easy answers like psychosocial factors.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0811
I was not so
M.J. Gordillo Monta˜no ∗, S. Ramos Perdigues ,
E. Guillén Guillén , O. Lopez Berastegui , M. Guisado Rico ,
S.V. Boned Torres , M. De Amuedo Rincon , C. Merino del Villar ,
S. Latorre
1 Hospital Can Misses, Psychiatry, Eivissa, Spain
2 Hospital Clinic, Psycho-oncology, Barcelona, Spain
3 Hospital Can Misses, Medicine, Eivissa, Spain
∗ Corresponding author.
Introduction The frontal lobes are the brain structures of latest
development and evolution in the human brain. It is considered
that the frontal lobes represent the “executive center of the brain”.
The frontal tumors represent 16% of all supratentorial tumors.
Symptoms are easily confused as psychiatric rather than neuro-
logical.