European Psychiatry - Volume 41 - April 2017

669 / 916

25th European Congress of Psychiatry / European Psychiatry 41S (2017) S645–S709 S665
is really close to the social representation of the rest of popu-
lation. To conclude, the authors will discuss about the influence
and impact of this social representation on the decision pro-
cess concerning the life project developed by the medical staff in
psychiatry
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0799
First neuropsychiatric symptoms and
neurocognitive correlates of
behavioral variant frontotemporal
dementia
H. Santamaría García ∗, P. Reyes , J.M. Santacruz-Escudero ,
D. Matallana , A. Iba˜nez
1 Pontificia Universidad Javeriana, Psychiatry, Physiology, Bogotá,
Colombia
2 Pontificia Universidad Javeriana, Psychiatry, Bogotá, Colombia
3 INCyt Laboratorio de Neurociencia Cognitiva y Traslacional,
INECO-U Favaloro, Buenos Aires, Argentina
∗ Corresponding author.
Previous works highlight the neurocognitive differences between
apathetic and disinhibited clinical presentations of the behavioral
variant frontotemporal dementia (bvFTD). However, little is known
regarding how the early presentation (i.e., first symptom) is asso-
ciated to the neurocognitive correlates of the disease’s clinical pre-
sentation at future stages of disease. We analyzed the neurocogni-
tive correlates of patients with bvFTD who debuted with apathy or
disinhibition as first symptom of disease. We evaluated the neuro-
psychological, clinical and neuroanatomical (3 T structural images)
correlates in a group of healthy controls (n = 30) and two groups of
bvFTD patients (presented with apathy [AbvFTD, n = 18] or disinhi-
bition [DbvFTD, n = 16]). To differentiate groups according to first
symptoms, we used multivariate analyses. The first symptom in
patients described the evolution of the disease. AbvFTDandDbvFTD
patients showed increased brain atrophy and increased levels of
disinhibition and apathy, respectively. Whole brain analyzes in
AbvFTD revealed atrophy in the frontal, insular and temporal areas.
DbvFTD, in turn, presented atrophy in the prefrontal regions, tem-
poroparietal junction, insula and temporoparietal region. Increased
atrophy in DbvFTD patients (compared to AbvFTD) was observed
in frontotemporal regions. Multivariate analyses confirmed that
a set of brain areas including right orbitofrontal, right dorsolat-
eral prefrontal and left caudate were enough to distinguish the
patients’ subgroups. First symptom in bvFTD patients described the
neurocognitive impairments after around three years of disease,
playing an important role in the early detection, disease tracking,
and neuroanatomical specification of bvFTD, as well as in future
research on potential disease-modifying treatments.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0800
Behavioral symptoms as predictor
factor of disease progression across
different neurocognitive disorders.
A longitudinal study
H. Santamaría García ∗, J.M. Santacruz Escudero , D. Matallana ,
A. Iba˜nez
1 Pontificia Universidad Javeriana, Psiquiatría, Bogotá, Colombia
2 Universidad Javeriana, Psychiatry, Bogotá, Colombia
3 Javeriana, Instituto envejecimiento, Bogota, Colombia
4 Instituto neurociencia Cognitiva y Traslacional INCyT, Neurociencia
Cognitiva, Buenos Aires, Argentina
∗ Corresponding author.
Background Previous works highlight the importance of neu-
rocognitive symptoms over cognitive and functional dependency
in neurocognitive disorders. However, little is known regarding
to what extent presence of neuropsychiatric symptoms pre-
dicts disease progression, cognitive and functional impairments
in behavioral variant frontotemporal dementia (bvFTD) and in
Alzheimer dementia.
Methods We performed two different evaluations (T1 and T2)
with 3 years of difference in a group of bvFTD (n = 18), AD (n = 20)
and controls (n = 22). Neuropsychological, clinical and cognitive
correlates weremeasured in each time T1 and T2. By using different
multiple regression models, we explored if behavioral symptoms
(measured by Columbia, Yesavage at T1) predict disease progres-
sion as measured by changes over T1 and T2 in cognitive (MoCA,
IFS, and clock figure) and functional dependency (Lawton).
Results Behavioral symptoms, in particular depression, psy-
chosis, apathy and disihinibition were factors able to predict
cognitive and functional progression in bvFTD. By contrast, regres-
sionmodel revealed that depression and insomnia were behavioral
factors able to predict progression in AD.
Conclusion Neuropsychiatric symptoms are crucial topredict dis-
ease progression in bvFTD and AD patients in differentiated ways.
Our results suggest tha tracking early behavioral symptoms in
neurocognitive disorders playing an important role in the early
detection, disease tracking, and neuroanatomical specification of
bvFTD, as well as in future research on potential disease-modifying
treatments.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0801
Mild cognitive impairments and
whole-body cryotherapy – Placebo
control study
K. Urba ´nska ∗, B. Sta ´nczykiewicz , D. Szcze´sniak , E. Trypka ,
A. Zabłocka , J. Rymaszewska
1 Wroclaw Medical University, Department of Psychiatry, Wroclaw,
Poland
2 Ludwik Hirszfeld Institute of Immunology and Experimental
Therapy, Polish Academy of Sciences, Department of
Immunochemistry, Wroclaw, Poland
∗ Corresponding author.
Introduction Cognitive impairment is considered to be a result of
oxidative stress and disturbances in inflammatory status. Whole-
body cryotherapy (WBC), which is a short exposure to extremely
low temperatures, probably regulates the release of cytokines and
nitric oxide. The hypothesis is that WBC may be useful in the ther-
apy of mild cognitive impairments (MCI).
Aims The effect of the whole-body cryotherapy (WBC) on cogni-
tive impairments was investigated.
Objectives In this study the observation of several biological fac-
tors and cognitive functions were conducted to analyse the WBC
influence on cognitive deficits.
Methods People with MCI participated in 10 WBC sessions
divided for experimental group (−110 ◦C till −160 ◦C) or control
group (−10 ◦C till −20 ◦C). The MoCa test (scores 26 and lower)
was used for inclusion criteria. Cognitive functions were measured
with: TYM, DemTect and SLUMS at baseline and in follow-up. Bio-
logical factors (cytokines, BDNF, NO) were also assessed.
Results It was shown that memory domains in experimental
group improved after WBC sessions. Also modulatory effect on
inflammatory mediators in plasma was shown. The results of this